HNRPF_MOUSE - dbPTM
HNRPF_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HNRPF_MOUSE
UniProt AC Q9Z2X1
Protein Name Heterogeneous nuclear ribonucleoprotein F
Gene Name Hnrnpf
Organism Mus musculus (Mouse).
Sequence Length 415
Subcellular Localization Nucleus, nucleoplasm.
Protein Description Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity)..
Protein Sequence MMLGPEGGEGYVVKLRGLPWSCSIEDVQNFLSDCTIHDGVAGVHFIYTREGRQSGEAFVELESEDDVKLALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLDRMRSGAYSAGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGLESQSVSGCYGAGYSGQNSMGGYD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MMLGPEGG
-------CCCCCCCC		4.52-
2Acetylation------MMLGPEGGE
------CCCCCCCCC		6.27-
11PhosphorylationGPEGGEGYVVKLRGL
CCCCCCCEEEEECCC		9.5825293948
14AcetylationGGEGYVVKLRGLPWS
CCCCEEEEECCCCCC		23.5622826441
21PhosphorylationKLRGLPWSCSIEDVQ
EECCCCCCCCHHHHH		8.9626643407
23PhosphorylationRGLPWSCSIEDVQNF
CCCCCCCCHHHHHHH		24.4026643407
54PhosphorylationYTREGRQSGEAFVEL
EECCCCCCCEEEEEE		36.9230635358
63PhosphorylationEAFVELESEDDVKLA
EEEEEECCHHHHHHH		59.9725619855
77PhosphorylationALKKDRESMGHRYIE
HHHHHHHHHCHHHHH		30.8423375375
87AcetylationHRYIEVFKSHRTEMD
HHHHHHHHHCHHHCE		50.9923806337
87UbiquitinationHRYIEVFKSHRTEMD
HHHHHHHHHCHHHCE		50.9922790023
98AcetylationTEMDWVLKHSGPNSA
HHCEEHHHCCCCCCC		26.5523806337
98UbiquitinationTEMDWVLKHSGPNSA
HHCEEHHHCCCCCCC		26.5522790023
100PhosphorylationMDWVLKHSGPNSADS
CEEHHHCCCCCCCCC		55.1221082442
104PhosphorylationLKHSGPNSADSANDG
HHCCCCCCCCCCCCC		36.2626824392
107PhosphorylationSGPNSADSANDGFVR
CCCCCCCCCCCCCEE		28.7823684622
123PhosphorylationRGLPFGCTKEEIVQF
CCCCCCCCHHHHHHH		41.7028059163
142PhosphorylationEIVPNGITLPVDPEG
EECCCCEEEECCCCC		26.8028059163
161PhosphorylationEAFVQFASQELAEKA
HHHHHHHCHHHHHHH		26.0222817900
167UbiquitinationASQELAEKALGKHKE
HCHHHHHHHHHHHHH		43.2222790023
171UbiquitinationLAEKALGKHKERIGH
HHHHHHHHHHHHHCH		52.97-
185UbiquitinationHRYIEVFKSSQEEVR
HHHHHHHHCCHHHHH		55.1422790023
186PhosphorylationRYIEVFKSSQEEVRS
HHHHHHHCCHHHHHH		26.2825266776
187PhosphorylationYIEVFKSSQEEVRSY
HHHHHHCCHHHHHHC		42.0526824392
193PhosphorylationSSQEEVRSYSDPPLK
CCHHHHHHCCCCCCE		33.88-
195PhosphorylationQEEVRSYSDPPLKFM
HHHHHHCCCCCCEEE		44.9127180971
200UbiquitinationSYSDPPLKFMSVQRP
HCCCCCCEEEEECCC		44.8122790023
200AcetylationSYSDPPLKFMSVQRP
HCCCCCCEEEEECCC		44.8123806337
203PhosphorylationDPPLKFMSVQRPGPY
CCCCEEEEECCCCCC		20.4525367039
210PhosphorylationSVQRPGPYDRPGTAR
EECCCCCCCCCCCHH		30.4225367039
212MethylationQRPGPYDRPGTARRY
CCCCCCCCCCCHHHH		26.2154556611
215PhosphorylationGPYDRPGTARRYIGI
CCCCCCCCHHHHHHH		21.4828066266
219PhosphorylationRPGTARRYIGIVKQA
CCCCHHHHHHHHHHH		9.6529514104
224MalonylationRRYIGIVKQAGLDRM
HHHHHHHHHHCHHHH		32.2926320211
224UbiquitinationRRYIGIVKQAGLDRM
HHHHHHHHHHCHHHH		32.29-
224AcetylationRRYIGIVKQAGLDRM
HHHHHHHHHHCHHHH		32.2922826441
233PhosphorylationAGLDRMRSGAYSAGY
HCHHHHHCCCCCCCC		20.5927600695
265PhosphorylationDLFGRDLSYCLSGMY
HHCCCCHHHHHHCCC		20.3525159016
267GlutathionylationFGRDLSYCLSGMYDH
CCCCHHHHHHCCCCC		1.8824333276
267S-nitrosylationFGRDLSYCLSGMYDH
CCCCHHHHHHCCCCC		1.8820925432
267S-nitrosocysteineFGRDLSYCLSGMYDH
CCCCHHHHHHCCCCC		1.88-
269PhosphorylationRDLSYCLSGMYDHRY
CCHHHHHHCCCCCCC		20.2525159016
272PhosphorylationSYCLSGMYDHRYGDS
HHHHHCCCCCCCCCC		16.4825159016
290S-nitrosocysteineVQSTTGHCVHMRGLP
EEECCCCEEEECCCC		2.08-
290GlutathionylationVQSTTGHCVHMRGLP
EEECCCCEEEECCCC		2.0824333276
290S-nitrosylationVQSTTGHCVHMRGLP
EEECCCCEEEECCCC		2.0820925432
299UbiquitinationHMRGLPYKATENDIY
EECCCCCCCCCCCCH		47.0622790023
301PhosphorylationRGLPYKATENDIYNF
CCCCCCCCCCCCHHC		31.0426239621
306PhosphorylationKATENDIYNFFSPLN
CCCCCCCHHCCCCCC		14.5826239621
310PhosphorylationNDIYNFFSPLNPVRV
CCCHHCCCCCCCEEE		25.0824925903
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HNRPF_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HNRPF_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HNRPF_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AT1A1_HUMANATP1A1physical
26496610
EMD_HUMANEMDphysical
26496610
HNRH1_HUMANHNRNPH1physical
26496610
HNRH2_HUMANHNRNPH2physical
26496610
LMNB1_HUMANLMNB1physical
26496610
PRIC3_HUMANPRICKLE3physical
26496610
HNRPM_HUMANHNRNPMphysical
26496610
MPCP_HUMANSLC25A3physical
26496610
M2OM_HUMANSLC25A11physical
26496610
MAP7_HUMANMAP7physical
26496610
DNJA3_HUMANDNAJA3physical
26496610
TRIPC_HUMANTRIP12physical
26496610
MATR3_HUMANMATR3physical
26496610
SC16A_HUMANSEC16Aphysical
26496610
RBM14_HUMANRBM14physical
26496610
MBB1A_HUMANMYBBP1Aphysical
26496610
EHMT2_HUMANEHMT2physical
26496610
LAR4B_HUMANLARP4Bphysical
26496610
F120A_HUMANFAM120Aphysical
26496610
TADBP_HUMANTARDBPphysical
26496610
RFOX2_HUMANRBFOX2physical
26496610
PKN3_HUMANPKN3physical
26496610
YTHD2_HUMANYTHDF2physical
26496610
TMCO1_HUMANTMCO1physical
26496610
MIC19_HUMANCHCHD3physical
26496610
ATD3A_HUMANATAD3Aphysical
26496610
CBX8_HUMANCBX8physical
26496610
LSM11_HUMANLSM11physical
26496610
TBB5_HUMANTUBBphysical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HNRPF_MOUSE

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Related Literatures of Post-Translational Modification

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