K2C79_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C79_MOUSE
• UniProt AC: Q8VED5
• Protein Name: Keratin, type II cytoskeletal 79
• Gene Name: Krt79
• Organism: Mus musculus (Mouse).
• Sequence Length: 531
• Protein Sequence: MRSSLSRQTFSTKGGFSSNSASGGGGSRMRTSYSSVTMSRGSGGGGGVRSGSSSGGFGSRSLYNLGGKNISVSMACGASSGRALGGFGSGAYVGLGASRQTFGPVCPPGGIQEVTVNQSLLTPLNVEIDPEIQRVRTQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQSQNTGVARSLEPFFENYLSTLRRQLDTKQSERGRLDMELRNVQDNLEDFKNKYEDEINKRTALENEFVLLKKDVDAAYMGRMDLHGKVDSLTQEIDFLQQLFEMELSQVQTNVSDTNVILSMDNNRNLDLDSIIAEVKAQYELIAQKSRAEAESWYQTKYEELQVTAGKHGDSLRDTKNEIAELTRTTQRLQGEVDAAKKQCQQLQTAIAEAEQNGEMALKDAKKKLGDLDTALHQAKEDLARMLREYQDLVSVKLALDMEIATYRKLLESEESRMSGDCPSAISISVTGNSTSVCAGGTAGFGNGLSLGGAGGASKGGFGSSVSYGAAKGGQVSGGTSILRKTTTVKTSSRRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MRSSLSRQTF -----CCCCCCCCCC	34.04	22324799
4	Phosphorylation	----MRSSLSRQTFS ----CCCCCCCCCCC	21.72	23140645
6	Phosphorylation	--MRSSLSRQTFSTK --CCCCCCCCCCCCC	25.04	22324799
20	Phosphorylation	KGGFSSNSASGGGGS CCCCCCCCCCCCCCC	26.26	27087446
27	Phosphorylation	SASGGGGSRMRTSYS CCCCCCCCCCCCEEC	26.61	-
31	Phosphorylation	GGGSRMRTSYSSVTM CCCCCCCCEECEEEE	23.75	30635358
32	Phosphorylation	GGSRMRTSYSSVTMS CCCCCCCEECEEEEC	16.80	30635358
33	Phosphorylation	GSRMRTSYSSVTMSR CCCCCCEECEEEECC	12.35	30635358
34	Phosphorylation	SRMRTSYSSVTMSRG CCCCCEECEEEECCC	20.35	30635358
35	Phosphorylation	RMRTSYSSVTMSRGS CCCCEECEEEECCCC	17.24	30635358
37	Phosphorylation	RTSYSSVTMSRGSGG CCEECEEEECCCCCC	16.04	30635358
39	Phosphorylation	SYSSVTMSRGSGGGG EECEEEECCCCCCCC	24.91	30635358
40	Methylation	YSSVTMSRGSGGGGG ECEEEECCCCCCCCC	32.26	16289363
42	Phosphorylation	SVTMSRGSGGGGGVR EEEECCCCCCCCCCC	32.90	30635358
50	Phosphorylation	GGGGGVRSGSSSGGF CCCCCCCCCCCCCCC	40.39	29899451
52	Phosphorylation	GGGVRSGSSSGGFGS CCCCCCCCCCCCCCC	23.68	19367708
53	Phosphorylation	GGVRSGSSSGGFGSR CCCCCCCCCCCCCCC	36.21	19367708
54	Phosphorylation	GVRSGSSSGGFGSRS CCCCCCCCCCCCCCC	44.63	19367708
59	Phosphorylation	SSSGGFGSRSLYNLG CCCCCCCCCCEEECC	19.21	29899451
61	Phosphorylation	SGGFGSRSLYNLGGK CCCCCCCCEEECCCC	36.58	19060867
145	Phosphorylation	QEREQIKTLNNKFAS HHHHHHHHHHHHHHH	36.03	29899451
149	Ubiquitination	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
152	Phosphorylation	TLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	22817900
156	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	27667366
229	Acetylation	NLEDFKNKYEDEINK HHHHHHHHHHHHHHH	51.08	-
236	Acetylation	KYEDEINKRTALENE HHHHHHHHHHHHHCE	57.71	-
343	Phosphorylation	KYEELQVTAGKHGDS HHHHCCHHCCCCCCC	19.41	24719451
515	Phosphorylation	GGQVSGGTSILRKTT CCCCCCCCCCCCCCE	19.00	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C79_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2C79_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C79_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of K2C79_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, AND MASSSPECTROMETRY.
PubMed: 19367708