ACOC_MOUSE - dbPTM
ACOC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACOC_MOUSE
UniProt AC P28271
Protein Name Cytoplasmic aconitate hydratase
Gene Name Aco1
Organism Mus musculus (Mouse).
Sequence Length 889
Subcellular Localization Cytoplasm.
Protein Description Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity).; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate..
Protein Sequence MKNPFAHLAEPLDAAQPGKRFFNLNKLEDSRYGRLPFSIRVLLEAAVRNCDEFLVKKNDIENILNWNVMQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNKERFEFLKWGSQAFCNMRIIPPGSGIIHQVNLEYLARVVFDQDGCYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYKLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSIAYLLQTGREEDKVKHIQKYLQAVGMFRDFNDTSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSEMKKDFESCLGAKQGFKGFQVAPDRHNDRKTFLYSNSEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVEAGLSVKPYIKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTVRIDFEKEPLGVNAQGRQVFLKDIWPTRDEIQAVERQHVIPGMFKEVYQKIETVNKSWNALAAPSEKLYAWNPKSTYIKSPPFFESLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTVHLPSGETLDVFDAAERYQQAGLPLIVLAGKEYGSGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGETADSLGLTGRERYTINIPEDLKPRMTVQIKLDTGKTFQAVMRFDTDVELTYFHNGGILNYMIRKMAQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Malonylation------MKNPFAHLA
------CCCCCHHHC		73.6326320211
2Ubiquitination------MKNPFAHLA
------CCCCCHHHC		73.63-
19UbiquitinationLDAAQPGKRFFNLNK
CCCCCCCCCCCCCCC		53.36-
19MalonylationLDAAQPGKRFFNLNK
CCCCCCCCCCCCCCC		53.3626320211
26MalonylationKRFFNLNKLEDSRYG
CCCCCCCCCCCCCCC		57.3226320211
26UbiquitinationKRFFNLNKLEDSRYG
CCCCCCCCCCCCCCC		57.3227667366
26AcetylationKRFFNLNKLEDSRYG
CCCCCCCCCCCCCCC		57.3222826441
30PhosphorylationNLNKLEDSRYGRLPF
CCCCCCCCCCCCCCH		20.30-
50S-palmitoylationLEAAVRNCDEFLVKK
HHHHHHCCHHHEECH		3.5728526873
56UbiquitinationNCDEFLVKKNDIENI
CCHHHEECHHCHHHH		48.26-
79UbiquitinationKNIEVPFKPARVILQ
CCCCCCCCCHHEEEE		31.5327667366
141AcetylationRRADSLQKNQDLEFE
CCHHHHHHCCCCHHH		62.9723954790
141MalonylationRRADSLQKNQDLEFE
CCHHHHHHCCCCHHH		62.9726320211
141UbiquitinationRRADSLQKNQDLEFE
CCHHHHHHCCCCHHH		62.9727667366
165S-palmitoylationKWGSQAFCNMRIIPP
HHHCCEEECCEEECC		4.3628526873
165S-nitrosocysteineKWGSQAFCNMRIIPP
HHHCCEEECCEEECC		4.36-
165S-nitrosylationKWGSQAFCNMRIIPP
HHHCCEEECCEEECC		4.3621278135
374MalonylationVPCCSGPKRPQDKVA
EECCCCCCCCCCCCC		79.0226320211
379UbiquitinationGPKRPQDKVAVSEMK
CCCCCCCCCCHHHHH		27.1827667366
379MalonylationGPKRPQDKVAVSEMK
CCCCCCCCCCHHHHH		27.1826320211
383PhosphorylationPQDKVAVSEMKKDFE
CCCCCCHHHHHHHHH		23.4130482847
386SuccinylationKVAVSEMKKDFESCL
CCCHHHHHHHHHHHH		45.1823954790
386UbiquitinationKVAVSEMKKDFESCL
CCCHHHHHHHHHHHH		45.1827667366
386MalonylationKVAVSEMKKDFESCL
CCCHHHHHHHHHHHH		45.1826320211
387MalonylationVAVSEMKKDFESCLG
CCHHHHHHHHHHHHC		67.3626320211
396AcetylationFESCLGAKQGFKGFQ
HHHHHCCCCCCCCEE		49.5122733758
396MalonylationFESCLGAKQGFKGFQ
HHHHHCCCCCCCCEE		49.5126320211
396UbiquitinationFESCLGAKQGFKGFQ
HHHHHCCCCCCCCEE		49.51-
455UbiquitinationGAGLLAKKAVEAGLS
CHHHHHHHHHHCCCC		52.65-
455AcetylationGAGLLAKKAVEAGLS
CHHHHHHHHHHCCCC		52.6523201123
464UbiquitinationVEAGLSVKPYIKTSL
HHCCCCCCCEEECCC		28.8227667366
464AcetylationVEAGLSVKPYIKTSL
HHCCCCCCCEEECCC		28.8223954790
464SuccinylationVEAGLSVKPYIKTSL
HHCCCCCCCEEECCC		28.8223954790
572MalonylationTVRIDFEKEPLGVNA
EEEEEECCCCCCCCC		65.7026320211
572UbiquitinationTVRIDFEKEPLGVNA
EEEEEECCCCCCCCC		65.70-
572SuccinylationTVRIDFEKEPLGVNA
EEEEEECCCCCCCCC		65.7023954790
572AcetylationTVRIDFEKEPLGVNA
EEEEEECCCCCCCCC		65.7023954790
587AcetylationQGRQVFLKDIWPTRD
CCCEEEEECCCCCHH		35.3923954790
610UbiquitinationHVIPGMFKEVYQKIE
CCCCHHHHHHHHHHH		37.06-
615UbiquitinationMFKEVYQKIETVNKS
HHHHHHHHHHHHHHH		25.4827667366
615AcetylationMFKEVYQKIETVNKS
HHHHHHHHHHHHHHH		25.4823864654
615SuccinylationMFKEVYQKIETVNKS
HHHHHHHHHHHHHHH		25.4823954790
615MalonylationMFKEVYQKIETVNKS
HHHHHHHHHHHHHHH		25.4826320211
621MalonylationQKIETVNKSWNALAA
HHHHHHHHHHHHCCC		53.1426320211
621UbiquitinationQKIETVNKSWNALAA
HHHHHHHHHHHHCCC		53.1427667366
630PhosphorylationWNALAAPSEKLYAWN
HHHCCCCCCCEECCC		42.5123984901
632AcetylationALAAPSEKLYAWNPK
HCCCCCCCEECCCCC		51.6523954790
632UbiquitinationALAAPSEKLYAWNPK
HCCCCCCCEECCCCC		51.65-
639SuccinylationKLYAWNPKSTYIKSP
CEECCCCCCCCCCCC		52.8223806337
639AcetylationKLYAWNPKSTYIKSP
CEECCCCCCCCCCCC		52.8223806337
639UbiquitinationKLYAWNPKSTYIKSP
CEECCCCCCCCCCCC		52.8227667366
639MalonylationKLYAWNPKSTYIKSP
CEECCCCCCCCCCCC		52.8226320211
644UbiquitinationNPKSTYIKSPPFFES
CCCCCCCCCCCCCCC		46.63-
708PhosphorylationLTPREFNSYGSRRGN
CCHHHCCCCCCCCCC		35.8729176673
711PhosphorylationREFNSYGSRRGNDAI
HHCCCCCCCCCCCCC		15.5729176673
732UbiquitinationANIRLLNKFLNKQAP
HHHHHHHHHHCCCCC		51.72-
736UbiquitinationLLNKFLNKQAPQTVH
HHHHHHCCCCCCEEE		50.40-
772UbiquitinationPLIVLAGKEYGSGSS
CEEEECCCCCCCCCC		42.00-
776PhosphorylationLAGKEYGSGSSRDWA
ECCCCCCCCCCCHHH		34.3020469934
778PhosphorylationGKEYGSGSSRDWAAK
CCCCCCCCCCHHHHC		24.7320469934
785UbiquitinationSSRDWAAKGPFLLGI
CCCHHHHCCHHHHCH		60.41-
844AcetylationINIPEDLKPRMTVQI
EECCCCCCCCEEEEE		42.7923954790
844UbiquitinationINIPEDLKPRMTVQI
EECCCCCCCCEEEEE		42.79-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACOC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACOC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACOC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ACOC_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACOC_MOUSE

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Related Literatures of Post-Translational Modification

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