EMAL3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EMAL3_MOUSE
• UniProt AC: Q8VC03
• Protein Name: Echinoderm microtubule-associated protein-like 3
• Gene Name: Eml3
• Organism: Mus musculus (Mouse).
• Sequence Length: 897
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic..
• Protein Sequence: MDGAAGPGEGPAHETLQTLSQRLRVQEEEMELVKAALAEALRLLRLHGSTTTLQGSGISAPTRNSSITVPPGLPPTCSPSLVTRGTQTEEELEIVPSSGPPGLSNGPPALQGGSEEPSGTQSEGGCSSSSGAGSPGPPGILRPVQPLQRSDTPRRNSSSSSSPSERPRQKLSRKAASSANLLLRSGSTESRGNKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPSGIRSLEELPSGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGVKLAEIKSTNDSVLAVGFSPRDSSCIVTSGKSHVHFWNWSGGTGAPGNGLLARKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILTWGRSVSDSKTPGRGGAKETYTIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGEGHALAWSMDLKETGLCADFHPSGAVVVVGLNTGRWLVLDTETREIVSDVTDGNEQLSVVRYSPDGLYLAIGSHDNMIYIYSVSSCGTKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKLLRNRYESRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYSGHGSHVTSVRFTHDDSYLVSLGGKDASIFQWRVLGAGSSGPAPATPSRTPSLSPASSLDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDGAAGPG -------CCCCCCCC	10.94	-
56	Phosphorylation	STTTLQGSGISAPTR CCCEECCCCCCCCCC	21.71	27841257
157	Phosphorylation	SDTPRRNSSSSSSPS CCCCCCCCCCCCCCC	29.77	26824392
158	Phosphorylation	DTPRRNSSSSSSPSE CCCCCCCCCCCCCCH	37.48	23684622
159	Phosphorylation	TPRRNSSSSSSPSER CCCCCCCCCCCCCHH	33.78	23684622
160	Phosphorylation	PRRNSSSSSSPSERP CCCCCCCCCCCCHHH	36.46	23684622
161	Phosphorylation	RRNSSSSSSPSERPR CCCCCCCCCCCHHHH	48.49	25266776
162	Phosphorylation	RNSSSSSSPSERPRQ CCCCCCCCCCHHHHH	34.10	25266776
164	Phosphorylation	SSSSSSPSERPRQKL CCCCCCCCHHHHHHH	48.46	25266776
177	Phosphorylation	KLSRKAASSANLLLR HHHHHHHHHHHHHHH	34.54	26824392
178	Phosphorylation	LSRKAASSANLLLRS HHHHHHHHHHHHHHC	19.22	27087446
185	Phosphorylation	SANLLLRSGSTESRG HHHHHHHCCCCCCCC	36.74	26643407
187	Phosphorylation	NLLLRSGSTESRGNK HHHHHCCCCCCCCCC	30.19	26643407
188	Phosphorylation	LLLRSGSTESRGNKD HHHHCCCCCCCCCCC	41.32	26643407
190	Phosphorylation	LRSGSTESRGNKDPL HHCCCCCCCCCCCCC	45.64	26643407
198	Phosphorylation	RGNKDPLSSPGGPGS CCCCCCCCCCCCCCC	39.62	22942356
199	Phosphorylation	GNKDPLSSPGGPGSR CCCCCCCCCCCCCCC	34.94	25521595
205	Phosphorylation	SSPGGPGSRRSNYNL CCCCCCCCCCCCCCC	27.88	25619855
208	Phosphorylation	GGPGSRRSNYNLEGI CCCCCCCCCCCCCCC	42.42	27841257
210	Phosphorylation	PGSRRSNYNLEGISV CCCCCCCCCCCCCEE	23.52	30635358
528	Phosphorylation	LCLRRDGTVLSGGGR EEECCCCEEEECCCC	23.67	28059163
578	Ubiquitination	ELLVGTTKNALLRGD EEEEECCCCHHHCCC	39.81	22790023
786	Phosphorylation	CVLGFHVYGVWPDGS EEEEEEEEEECCCCC	9.44	-
875	Phosphorylation	WRVLGAGSSGPAPAT EEEECCCCCCCCCCC	31.42	28066266
876	Phosphorylation	RVLGAGSSGPAPATP EEECCCCCCCCCCCC	48.13	29514104
882	Phosphorylation	SSGPAPATPSRTPSL CCCCCCCCCCCCCCC	22.27	26824392
884	Phosphorylation	GPAPATPSRTPSLSP CCCCCCCCCCCCCCC	44.42	26745281
886	Phosphorylation	APATPSRTPSLSPAS CCCCCCCCCCCCCCH	22.90	28833060
888	Phosphorylation	ATPSRTPSLSPASSL CCCCCCCCCCCCHHC	40.65	28833060
890	Phosphorylation	PSRTPSLSPASSLDV CCCCCCCCCCHHCCC	23.82	22942356
893	Phosphorylation	TPSLSPASSLDV--- CCCCCCCHHCCC---	34.51	28833060
894	Phosphorylation	PSLSPASSLDV---- CCCCCCHHCCC----	30.60	28833060

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EMAL3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
882	T	Phosphorylation	Phosphorylation at Thr-882 during mitosis is required for interaction with TUBG1, HAUS1, HAUS2, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7 and HAUS8 and their recruitement to spindle microtubules.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EMAL3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EMAL3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.