DSG1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DSG1A_MOUSE
• UniProt AC: Q61495
• Protein Name: Desmoglein-1-alpha
• Gene Name: Dsg1a
• Organism: Mus musculus (Mouse).
• Sequence Length: 1057
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
• Protein Description: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion..
• Protein Sequence: MDWHSFRIAALLLTSLVVLEVNSEFQIQVRDHNAKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQPVTYRISGVGIDQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDINDNPPVFSMTTFLGQIEENSNANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEIRTMNNFLDREQYSQYSLVVRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDITIEENALHSQLVQIRVIDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDYEAMKNLQLSIGVRNVAEFHQSIISQYRLTATMVTVTVLNVIEGSVFRPGSKTFVVDSRMEANHRVGEFVATDLDTGRASTNVRYEMGNNPENLLVVDSRTGIITLRNRVTMEQYQRLNGEYKGTVLSIDDSLQRTCTGTIVIELSGTGWVTGSESGGSSSGSGDDRDRVTNGYQGTSSTENPQRVTGSWGGSGIDGTRPNTNPFQGDPDETLETPLYGDNVHFGPAGIGLLIMGFLVLGLVPFLLICCDCGGAPGGGAGFEPVPECSDGAIHTWAVEGPQPEPHEGITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGFELMDGVKTSAAPEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDESFLDTLGPKFKKLADISLGKEIDSYPDSDPSWPPQSTEPMCPQHTEPLGSGHPPISPHFGTTTVISENAYHSGPGVQHPVPIPDPLGYGNVTVRESYTTSGTLKPSVHFHDNQQASNVVVTERVVGPISGADLHGMLEIPDLRGGANVIVTERVIAPGSSLPTSLTIPNPQETSNVVVTERVIQPTSGMIGNLSMTPELSSAHNVIVTERVVSGAGMSEIAGTAGLGGVGGIGSSGLVSTTMGASGTGLNMGGTATIGHMRSSSDHHFSQTVGSASPSMARSRITKYNTVQYSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	N-linked_Glycosylation	NQKTGEINITSIVDR ECCCCEEEEEEEECC	27.47	-
180	N-linked_Glycosylation	NTLVMKLNATDADEP CEEEEEEECCCCCCC	34.96	-
693	Phosphorylation	ICQEYSGTLRRNSMR HHHHHCCCCCCCCHH	15.91	23140645
1025	Phosphorylation	ATIGHMRSSSDHHFS EEECCCCCCCCCCCC	26.98	22817900
1037	Phosphorylation	HFSQTVGSASPSMAR CCCCCCCCCCHHHHH	22.64	19367708
1039	Phosphorylation	SQTVGSASPSMARSR CCCCCCCCHHHHHHH	21.14	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DSG1A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DSG1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DSG1A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DSG1A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.