HUTH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HUTH_MOUSE
• UniProt AC: P35492
• Protein Name: Histidine ammonia-lyase
• Gene Name: Hal
• Organism: Mus musculus (Mouse).
• Sequence Length: 657
• Protein Sequence: MPRYTVHVRGEWLAVPCQDGKLTVGWLGREAVRRYMKNKPDNGGFTSVDEVQFLVHRCKGLGLLDNEDELEVALEDNEFVEVVIEGDVMSPDFIPSQPEGVFLYSKYREPEKYIALDGDSLSTEDLVNLGKGRYKIKLTSIAEKKVQQSREVIDSIIKERTVVYGITTGFGKFARTVIPANKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEAFNASCLSYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSPKSGWADAKYVLEAHGLKPIVLKPKEGLALINGTQMITSLGCEALERASAIARQADIVAALTLEVLKGTTKAFDTDIHAVRPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVVEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLESLRKNSATIPESDDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Ubiquitination	EAVRRYMKNKPDNGG HHHHHHHHCCCCCCC	53.54	-
112	Acetylation	SKYREPEKYIALDGD ECCCCCCCEEEECCC	53.31	22733758
112	Ubiquitination	SKYREPEKYIALDGD ECCCCCCCEEEECCC	53.31	-
113	Phosphorylation	KYREPEKYIALDGDS CCCCCCCEEEECCCC	6.97	17242355
131	Ubiquitination	EDLVNLGKGRYKIKL HHHHHCCCCCEEEEE	43.30	-
131	Succinylation	EDLVNLGKGRYKIKL HHHHHCCCCCEEEEE	43.30	23954790
137	Ubiquitination	GKGRYKIKLTSIAEK CCCCEEEEEHHHHHH	41.37	-
137	Malonylation	GKGRYKIKLTSIAEK CCCCEEEEEHHHHHH	41.37	26320211
140	Phosphorylation	RYKIKLTSIAEKKVQ CEEEEEHHHHHHHHH	30.18	23984901
144	Malonylation	KLTSIAEKKVQQSRE EEHHHHHHHHHHHHH	49.58	26320211
144	Succinylation	KLTSIAEKKVQQSRE EEHHHHHHHHHHHHH	49.58	23954790
158	Malonylation	EVIDSIIKERTVVYG HHHHHHHHHCEEEEE	39.20	26320211
158	Ubiquitination	EVIDSIIKERTVVYG HHHHHHHHHCEEEEE	39.20	-
172	Acetylation	GITTGFGKFARTVIP EEECCCHHHHCEEEE	33.32	23954790
172	Ubiquitination	GITTGFGKFARTVIP EEECCCHHHHCEEEE	33.32	-
176	Phosphorylation	GFGKFARTVIPANKL CCHHHHCEEEEHHHH	21.25	21454597
182	Acetylation	RTVIPANKLQELQVN CEEEEHHHHHHHHHH	54.37	23954790
182	Ubiquitination	RTVIPANKLQELQVN CEEEEHHHHHHHHHH	54.37	-
200	Malonylation	SHSSGVGKPLSPERC HCCCCCCCCCCHHHH	40.14	30639696
200	Acetylation	SHSSGVGKPLSPERC HCCCCCCCCCCHHHH	40.14	23954790
200	Ubiquitination	SHSSGVGKPLSPERC HCCCCCCCCCCHHHH	40.14	-
203	Phosphorylation	SGVGKPLSPERCRML CCCCCCCCHHHHHHH	32.99	29472430
220	Ubiquitination	LRINVLAKGYSGISL HHHHHHHCCCCCCCH	54.97	-
254	Other	EKGTVGASGDLAPLS CCCCCCCCCCCHHHH	27.23	-
254	"2,3-didehydroalanine (Ser)"	EKGTVGASGDLAPLS CCCCCCCCCCCHHHH	27.23	-
277	Ubiquitination	EGKMWSPKSGWADAK CCCCCCCCCCCCCHH	56.96	-
277	Succinylation	EGKMWSPKSGWADAK CCCCCCCCCCCCCHH	56.96	23954790
284	Acetylation	KSGWADAKYVLEAHG CCCCCCHHHHHHHCC	36.12	23954790
293	Ubiquitination	VLEAHGLKPIVLKPK HHHHCCCCCEEECCC	36.97	-
298	Ubiquitination	GLKPIVLKPKEGLAL CCCCEEECCCCCEEE	43.05	-
300	Ubiquitination	KPIVLKPKEGLALIN CCEEECCCCCEEEEC	63.93	-
342	Ubiquitination	ALTLEVLKGTTKAFD HHHHHHHCCCCCCCC	60.43	-
346	Ubiquitination	EVLKGTTKAFDTDIH HHHCCCCCCCCCCEE	47.06	-
396	Phosphorylation	DRVQDAYTLRCCPQV CCCCCCHHHCCCCCC	14.94	22817900
578	Ubiquitination	KTTTPLEKVYDLVRS CCCCCHHHHHHHHHH	54.50	-
578	Acetylation	KTTTPLEKVYDLVRS CCCCCHHHHHHHHHH	54.50	23954790
592	Malonylation	SVVRPWIKDRFMAPD HHHHHHHHCCCCCCC	38.69	26320211
592	Ubiquitination	SVVRPWIKDRFMAPD HHHHHHHHCCCCCCC	38.69	-
611	Ubiquitination	HRLLLDQKVWEVAAP HHHHHCHHHHHHHHH	49.32	-
611	Acetylation	HRLLLDQKVWEVAAP HHHHHCHHHHHHHHH	49.32	23954790
622	Ubiquitination	VAAPYIEKYRMEHIP HHHHHHHHHCHHCCC	28.70	-
622	Acetylation	VAAPYIEKYRMEHIP HHHHHHHHHCHHCCC	28.70	23954790
623	Phosphorylation	AAPYIEKYRMEHIPE HHHHHHHHCHHCCCC	11.47	23140645
625	Oxidation	PYIEKYRMEHIPESR HHHHHHCHHCCCCCC	3.89	17242355
631	Phosphorylation	RMEHIPESRPLSPTA CHHCCCCCCCCCCCC	33.57	21082442
635	Phosphorylation	IPESRPLSPTAFSLE CCCCCCCCCCCCCHH	23.92	25521595
637	Phosphorylation	ESRPLSPTAFSLESL CCCCCCCCCCCHHHH	36.64	25521595
640	Phosphorylation	PLSPTAFSLESLRKN CCCCCCCCHHHHHHC	28.85	23737553
643	Phosphorylation	PTAFSLESLRKNSAT CCCCCHHHHHHCCCC	38.47	21743459
648	Phosphorylation	LESLRKNSATIPESD HHHHHHCCCCCCCCC	29.80	25521595
650	Phosphorylation	SLRKNSATIPESDDL HHHHCCCCCCCCCCC	36.56	26487105
654	Phosphorylation	NSATIPESDDL---- CCCCCCCCCCC----	30.94	28609623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HUTH_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HUTH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HUTH_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HUTH_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-635, AND MASSSPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631; SER-635 ANDSER-648, AND MASS SPECTROMETRY.
PubMed: 17242355

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648, AND MASSSPECTROMETRY.
PubMed: 17203969