GUC2C_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GUC2C_MOUSE
• UniProt AC: Q3UWA6
• Protein Name: Heat-stable enterotoxin receptor
• Gene Name: Gucy2c
• Organism: Mus musculus (Mouse).
• Sequence Length: 1072
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. The 145 kDa plasma membrane form of GC-C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda
• Protein Description: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin (By similarity)..
• Protein Sequence: MTSLLGLAVRLLLFQPALMVFWASQVRQNCRNGSYEISVLMMDNSAYKEPMQNLREAVEEGLDIVRKRLREADLNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDHKMGCALMGPSCTYSTFQMYLDTELNYPMISAGSYGLSCDYKETLTRILPPARKLMYFLVDFWKVNNASFKPFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEVLNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVKGDLQVAEDTVVILVDLFSNHYFEENTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSLAYLEGTLLFGHMLQTFLENGENVTGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKYKVLMKYDTHKNKTIPVAENPNFIWKNHKLPNDVPGLGPQILMIAVFTLTGILVVLLLIALLVLRKYRRDHALRQKKWSHIPSENIFPLETNETNHISLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFAIIAQEIILRKETFYTLSCRDHNEKIFRVENSYGKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPSPPTVENQQRLQTEFSDMIVSALQKRQASGKKSRRPTRVASYKKGFLEYMQLNNSDHDSTYF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	N-linked_Glycosylation	QVRQNCRNGSYEISV HHHHHCCCCCEEEEE	46.06	-
75	N-linked_Glycosylation	RLREADLNVTVNATF HHHHCCCCEEEEEEE	28.14	-
79	N-linked_Glycosylation	ADLNVTVNATFIYSD CCCCEEEEEEEEECC	24.73	-
179	N-linked_Glycosylation	VDFWKVNNASFKPFS HCHHCCCCCCCCCCC	39.69	-
188	N-linked_Glycosylation	SFKPFSWNSSYVYKN CCCCCCCCCCCEECC	21.63	-
195	N-linked_Glycosylation	NSSYVYKNGSEPEDC CCCCEECCCCCHHHH	41.35	-
284	N-linked_Glycosylation	SNHYFEENTTAPEYM CCCCCCCCCCCCHHC	35.22	-
307	N-linked_Glycosylation	PSEQSTSNTSVAERF CCCCCCCCCCHHHHH	36.14	-
345	N-linked_Glycosylation	TFLENGENVTGPKFA HHHHCCCCCCCHHHH	37.74	-
402	N-linked_Glycosylation	MKYDTHKNKTIPVAE EEEECCCCCEEECCC	38.81	-
838	Phosphorylation	GFTTICKYSTPMEVV CCEEEECCCCCHHHH	17.23	21189417
852	Phosphorylation	VDMLNDIYKSFDQIV HHHHHHHHHHHHHHC	11.93	21189417

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GUC2C_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
75	N	Glycosylation	Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GC-C activation.	-
79	N	Glycosylation	Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GC-C activation.	-
345	N	Glycosylation	Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GC-C activation.	-
402	N	Glycosylation	Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GC-C activation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GUC2C_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GUC2C_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.