dbPTM

K1C17_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	K1C17_MOUSE
UniProt AC	Q9QWL7
Protein Name	Keratin, type I cytoskeletal 17
Gene Name	Krt17
Organism	Mus musculus (Mouse).
Sequence Length	433
Subcellular Localization	Cytoplasm .
Protein Description	Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. [PubMed: 14714564]
Protein Sequence	MTTTIRQFTSSSSIKGSSGLGGGSSRTSCRLSGSLGAGSCRLGSASGLGSALGSNSYSSCYSFGTGSGYGGNFGGVDGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQKQAPGPARDYSAYYHTIEDLKNKILVATVDNASILLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILSEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGSLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKPKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTTTIRQFT ------CCCCCHHHC	32.42	30635358
3	Phosphorylation	-----MTTTIRQFTS -----CCCCCHHHCC	20.94	30635358
4	Phosphorylation	----MTTTIRQFTSS ----CCCCCHHHCCC	12.66	30635358
9	Phosphorylation	TTTIRQFTSSSSIKG CCCCHHHCCCCCCCC	21.25	22817900
10	Phosphorylation	TTIRQFTSSSSIKGS CCCHHHCCCCCCCCC	29.52	30635358
11	Phosphorylation	TIRQFTSSSSIKGSS CCHHHCCCCCCCCCC	25.66	22006019
12	Phosphorylation	IRQFTSSSSIKGSSG CHHHCCCCCCCCCCC	35.53	22817900
13	Phosphorylation	RQFTSSSSIKGSSGL HHHCCCCCCCCCCCC	30.21	22817900
17	Phosphorylation	SSSSIKGSSGLGGGS CCCCCCCCCCCCCCC	19.07	30635358
18	Phosphorylation	SSSIKGSSGLGGGSS CCCCCCCCCCCCCCC	46.86	30635358
24	Phosphorylation	SSGLGGGSSRTSCRL CCCCCCCCCCCCEEC	21.66	30635358
25	Phosphorylation	SGLGGGSSRTSCRLS CCCCCCCCCCCEECC	42.74	30635358
32	Phosphorylation	SRTSCRLSGSLGAGS CCCCEECCCCCCCCC	13.64	22817900
34	Phosphorylation	TSCRLSGSLGAGSCR CCEECCCCCCCCCCC	21.91	22817900
39	Phosphorylation	SGSLGAGSCRLGSAS CCCCCCCCCCCCCCC	8.77	22817900
44	Phosphorylation	AGSCRLGSASGLGSA CCCCCCCCCCCCCHH	24.69	22006917
97	Phosphorylation	NLNDRLASYLDKVRA HHHHHHHHHHHHHHH	30.71	-
110	Phosphorylation	RALEEANTELEVKIR HHHHHHCCCHHHHHH	49.33	-
142	Ubiquitination	YHTIEDLKNKILVAT CCCHHHHCCCEEEEE	69.39	-
172	Ubiquitination	AADDFRTKFETEQAL CCHHHHHHHHHHHHH	36.63	-
182	Phosphorylation	TEQALRMSVEADING HHHHHHHHHHHCHHH	15.46	-
279	Phosphorylation	EDWFFSKTEELNREV HHHHCCCHHHHCHHH	33.23	-
307	Oxidation	ISELRRTMQALEIEL HHHHHHHHHHHHHHH	1.76	17203969
319	Phosphorylation	IELQSQLSMKASLEG HHHHHHHHHHHHHCC	15.59	17203969
320	Oxidation	ELQSQLSMKASLEGS HHHHHHHHHHHHCCC	5.97	17203969
323	Phosphorylation	SQLSMKASLEGSLAE HHHHHHHHHCCCHHH	22.80	-
401	Ubiquitination	HLTQYKPKEPVTTRQ CCCCCCCCCCCCHHH	71.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
44	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
44	S	Phosphorylation	Kinase	P90RSK	P18653	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
44	S	Phosphorylation		16710422
Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of K1C17_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of K1C17_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of K1C17_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, AND MASSSPECTROMETRY.	17203969 [Abstract]

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