CRYAB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRYAB_MOUSE
• UniProt AC: P23927
• Protein Name: Alpha-crystallin B chain
• Gene Name: Cryab
• Organism: Mus musculus (Mouse).
• Sequence Length: 175
• Subcellular Localization: Cytoplasm . Nucleus . Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Localizes at the Z-bands and the intercalated disk in cardiomyocytes.
• Protein Description: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions..
• Protein Sequence: MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFSTATSLSPFYLRPPSFLRAPSWIDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVAAAPKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDIAIHHP -------CCCEECCC	8.31	-
19	Phosphorylation	RPFFPFHSPSRLFDQ CCCCCCCCHHHHHHH	25.58	9774459
21	Phosphorylation	FFPFHSPSRLFDQFF CCCCCCHHHHHHHHH	44.63	23737553
22	Methylation	FPFHSPSRLFDQFFG CCCCCHHHHHHHHHH	42.64	-
45	Phosphorylation	FSTATSLSPFYLRPP CCCCCCCCCCCCCCH	16.84	9774459
50	Methylation	SLSPFYLRPPSFLRA CCCCCCCCCHHHHCC	29.69	-
59	Phosphorylation	PSFLRAPSWIDTGLS HHHHCCCHHHHCCHH	35.36	25521595
63	Phosphorylation	RAPSWIDTGLSEMRL CCCHHHHCCHHHHCC	30.78	27742792
66	Phosphorylation	SWIDTGLSEMRLEKD HHHHCCHHHHCCCCC	30.59	21082442
72	Ubiquitination	LSEMRLEKDRFSVNL HHHHCCCCCCEEEEE	59.81	22790023
76	Phosphorylation	RLEKDRFSVNLDVKH CCCCCCEEEEEECCC	15.81	26824392
82	Ubiquitination	FSVNLDVKHFSPEEL EEEEEECCCCCHHHH	38.30	22790023
85	Phosphorylation	NLDVKHFSPEELKVK EEECCCCCHHHHEEE	30.99	27742792
90	Ubiquitination	HFSPEELKVKVLGDV CCCHHHHEEEEEEEE	43.20	22790023
92	Ubiquitination	SPEELKVKVLGDVIE CHHHHEEEEEEEEEE	30.10	22790023
92	Acetylation	SPEELKVKVLGDVIE CHHHHEEEEEEEEEE	30.10	-
103	Ubiquitination	DVIEVHGKHEERQDE EEEEECCCCCHHCCC	32.72	22790023
150	Ubiquitination	LTVNGPRKQVSGPER EEECCCCCCCCCCCC	59.18	22790023
158	Phosphorylation	QVSGPERTIPITREE CCCCCCCEECCCCCC	29.46	-
162	O-linked_Glycosylation	PERTIPITREEKPAV CCCEECCCCCCCCCC	27.03	30016717
166	Acetylation	IPITREEKPAVAAAP ECCCCCCCCCCEECC	33.26	-
166	Ubiquitination	IPITREEKPAVAAAP ECCCCCCCCCCEECC	33.26	22790023
174	Ubiquitination	PAVAAAPKK------ CCCEECCCC------	67.40	-
175	Ubiquitination	AVAAAPKK------- CCEECCCC-------	65.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
45	S	Phosphorylation	Kinase	ERK1	P27361	PSP
45	S	Phosphorylation	Kinase	PKN1	P70268	PSP
59	S	Phosphorylation	Kinase	P38A	Q16539	PSP
59	S	Phosphorylation	Kinase	MAPK14	P47811	GPS
59	S	Phosphorylation	Kinase	PKN1	P70268	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRYAB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRYAB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CRYAB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.