dbPTM

SAC31_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SAC31_MOUSE
UniProt AC	A6H687
Protein Name	SAC3 domain-containing protein 1
Gene Name	Sac3d1
Organism	Mus musculus (Mouse).
Sequence Length	427
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Localizes on centrosomes in interphase cells and at spindles in mitosis.
Protein Description	Involved in centrosome duplication and mitotic progression..
Protein Sequence	MGRFKGENRSQARWIMGGVSKGRGSGKSRKPRQAAFGQTGARVCPSSPQQDAVPRFRWPGDAECASSTHTPTMSGCKLPMGLCPDMCPAAERARRERERRLHRLEVEPGGRGNAPRADPKRTVKEYSRPAAGKPRPPPSLLRPPPVLLATVRYLAGEVAGRGDVSCAEVASFVADRLRAVRLDLSLQGVDDADAATVLEAALATLLAVVARVRPEETRGAADPVLLQTQVQEGFGSLRRCYARGKGPYPRQAAFQGLFLLYNLGSVEALQEVLQLPAALRACPPLQAALAVDAAFREDNHARLFRLLRTLPYLQSCAVQEHIGYARRKALARLSRALSTPKGQTLPLDFIEHFLALDGLQEARDLCQAHGLTLDKDRVVFLRGQYSEEGLPPPGAYHILVGNKLQGHTLEDVVMAEEGDIHRPGSAA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	PGDAECASSTHTPTM CCCCHHHCCCCCCCC	47.64	-
111	Methylation	LEVEPGGRGNAPRAD CCCCCCCCCCCCCCC	40.90	16289027
116	Methylation	GGRGNAPRADPKRTV CCCCCCCCCCCCCCH	49.57	18958317
153	Phosphorylation	VLLATVRYLAGEVAG EEHHHHHHHHHHHCC	9.14	23140645
165	Phosphorylation	VAGRGDVSCAEVASF HCCCCCCCHHHHHHH	16.61	23140645
171	Phosphorylation	VSCAEVASFVADRLR CCHHHHHHHHHHHHH	25.98	23140645
236	Phosphorylation	QVQEGFGSLRRCYAR HHHHCCCCHHHHHHC	19.22	26824392
425	Phosphorylation	GDIHRPGSAA----- CCCCCCCCCC-----	24.57	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SAC31_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SAC31_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SAC31_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SAC31_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SAC31_MOUSE

Related Literatures of Post-Translational Modification