CADH2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CADH2_MOUSE
• UniProt AC: P15116
• Protein Name: Cadherin-2
• Gene Name: Cdh2
• Organism: Mus musculus (Mouse).
• Sequence Length: 906
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cell membrane, sarcolemma . Cell junction . Cell surface . Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes (PubMed:26403541). Colocalizes with OBSCN at the intercalated disk and
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. [PubMed: 24952463 CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.]
• Protein Sequence: MCRIAGAPRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAVNLSREPTLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTINRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
190	N-linked_Glycosylation	IRSDRDKNLSLRYSV ECCCCCCCEEEEEEE	38.87	-
273	N-linked_Glycosylation	EFLHQVWNGSVPEGS HHHHHHHCCCCCCCC	33.72	21300292
325	N-linked_Glycosylation	PNMFTINNETGDIIT CCEEEECCCCCCEEE	44.34	21300292
402	N-linked_Glycosylation	RVDVIVANLTVTDKD CEEEEEEECEECCCC	25.92	21300292
423	Phosphorylation	WNAAYRISGGDPTGR CEEEEEECCCCCCCC	27.94	-
454	Phosphorylation	VKPIDFETNRMFVLT EEEECCCCCCEEEEE	28.28	-
572	N-linked_Glycosylation	NVKNNIYNATFLASD CCCCCEEEEEEEEEC	28.80	21300292
647	Phosphorylation	DLPLSPVTIKRNWTI ECCCCCEEEECCEEE	24.94	24759943
651	N-linked_Glycosylation	SPVTIKRNWTINRLN CCEEEECCEEEEECC	34.93	21300292
691	Phosphorylation	DSGNPPKSNISILRV CCCCCCCCCEEEEEE	45.21	27180971
692	N-linked_Glycosylation	SGNPPKSNISILRVK CCCCCCCCEEEEEEE	37.85	-
694	Phosphorylation	NPPKSNISILRVKVC CCCCCCEEEEEEEEE	21.59	27180971
756	Ubiquitination	RDKERQAKQLLIDPE CCHHHHHHHHCCCCC	32.89	22790023
788	Phosphorylation	EDQDYDLSQLQQPDT CCCCCCHHHCCCCCC	26.41	23737553
824	Phosphorylation	EPQYPVRSAAPHPGD CCCCCCCCCCCCCCC	29.08	26370283
852	Phosphorylation	NDPTAPPYDSLLVFD CCCCCCCCCEEEEEE	19.66	10502299
884	Phosphorylation	SSGGDQDYDYLNDWG CCCCCCCHHHHHCCC	10.80	10502299

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
852	Y	Phosphorylation	Kinase	SRC	P05480	PSP
852	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
884	Y	Phosphorylation	Kinase	SRC	P05480	PSP
884	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CADH2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CADH2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRP5_MOUSE	Lrp5	genetic	19075000
LRP5_MOUSE	Lrp5	physical	19075000
LRP6_MOUSE	Lrp6	physical	19075000
LRP6_MOUSE	Lrp6	genetic	19075000
WNT3A_MOUSE	Wnt3a	physical	19075000
AXIN1_MOUSE	Axin1	physical	19075000
CTNB1_MOUSE	Ctnnb1	physical	12695331
KIFA3_MOUSE	Kifap3	physical	15834408
KIF3B_MOUSE	Kif3b	physical	15834408
CTNB1_MOUSE	Ctnnb1	physical	15834408
CTND1_MOUSE	Ctnnd1	physical	15834408
KIF5C_MOUSE	Kif5c	physical	15834408
CSK_MOUSE	Csk	physical	15861137
P85A_MOUSE	Pik3r1	physical	15192701
ARVC_MOUSE	Arvcf	physical	11719554
NUMB_MOUSE	Numb	physical	17589506
NMDZ1_MOUSE	Grin1	physical	17589506

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.