dbPTM

NMDZ1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NMDZ1_MOUSE
UniProt AC	P35438
Protein Name	Glutamate receptor ionotropic, NMDA 1
Gene Name	Grin1
Organism	Mus musculus (Mouse).
Sequence Length	938
Subcellular Localization	Cell membrane Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Enriched in postsynaptic plasma membrane and postsynaptic densities..
Protein Description	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). [PubMed: 1532151]
Protein Sequence	MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEARDLEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCVDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	N-linked_Glycosylation	GSWKIQLNATSVTHK CCEEEEEECEECCCC	25.46	-
203	N-linked_Glycosylation	QFDPGTKNVTALLME CCCCCCCCHHHHHHH	35.89	-
239	N-linked_Glycosylation	YRAAAMLNMTGSGYV HHHHHHHHCCCCCEE	16.94	-
276	N-linked_Glycosylation	LQLINGKNESAHISD EEEECCCCCCCCHHH	50.26	-
300	N-linked_Glycosylation	HELLEKENITDPPRG HHHHHHCCCCCCCCC	54.23	-
317	Phosphorylation	GNTNIWKTGPLFKRV CCCCHHHCCHHHHHH	29.09	-
350	N-linked_Glycosylation	DGDRKFANYSIMNLQ CCCCCEEEEEEEECC	33.93	-
368	N-linked_Glycosylation	LVQVGIYNGTHVIPN EEEEEEECCCEECCC	47.14	-
386	Phosphorylation	IIWPGGETEKPRGYQ EECCCCCCCCCCCCC	53.21	21454597
440	N-linked_Glycosylation	KVICTGPNDTSPGSP EEEECCCCCCCCCCC	67.54	-
471	N-linked_Glycosylation	IKLARTMNFTYEVHL HHHHHHCCCEEEEEE	26.04	-
491	N-linked_Glycosylation	FGTQERVNNSNKKEW CCCHHCCCCCCHHHH	53.05	-
674	N-linked_Glycosylation	INDPRLRNPSDKFIY CCCHHHCCCCCCEEE	45.05	-
771	N-linked_Glycosylation	KDSPWKQNVSLSILK CCCCCCCCEEEEHHH	22.94	-
860 (in isoform 2)	Ubiquitination	-	46.42	-
867	Phosphorylation	KNLQDRKSGRAEPDP HHHHHCCCCCCCCCH	34.11	29899451
877 (in isoform 2)	Phosphorylation	-	59.80	-
886	Phosphorylation	TFRAITSTLASSFKR HHHHHHHHHHHHHCH	20.07	29899451
889	Phosphorylation	AITSTLASSFKRRRS HHHHHHHHHHCHHHC	39.15	22324799
890	Phosphorylation	ITSTLASSFKRRRSS HHHHHHHHHCHHHCC	29.22	25521595
896	Phosphorylation	SSFKRRRSSKDTSTG HHHCHHHCCCCCCCC	39.67	19834457
897	Phosphorylation	SFKRRRSSKDTSTGG HHCHHHCCCCCCCCC	32.51	16682960
913	Ubiquitination	RGALQNQKDTVLPRR CHHHHCCCCCCCCHH	64.02	-
932	S-palmitoylation	EEGQLQLCSRHRES- HHHHHCCHHHCCCC-	1.85	28680068

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
889	S	Phosphorylation	Kinase	PKC	-	Uniprot
896	S	Phosphorylation	Kinase	PKC	-	Uniprot
897	S	Phosphorylation	Kinase	PKC	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Fbxo2	Q80UW2	PMID:25878288

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
897	S	Phosphorylation		-
Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NMDZ1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NMDE1_MOUSE	Grin2a	physical	10862698
NMDE2_MOUSE	Grin2b	physical	10862698
DLG4_MOUSE	Dlg4	physical	10862698
DLG2_MOUSE	Dlg2	physical	10862698
NOS1_MOUSE	Nos1	physical	10862698
SYGP1_MOUSE	Syngap1	physical	10862698
DLGP1_MOUSE	Dlgap1	physical	10862698
CTRO_MOUSE	Cit	physical	10862698
GRM1_MOUSE	Grm1	physical	10862698
HOME1_MOUSE	Homer1	physical	10862698
DLG3_MOUSE	Dlg3	physical	10862698
SHAN2_MOUSE	Shank2	physical	10862698
AKAP5_MOUSE	Akap5	physical	10862698
NSF_MOUSE	Nsf	physical	10862698
AKAP9_MOUSE	Akap9	physical	10862698
KAPCA_MOUSE	Prkaca	physical	10862698
KAP3_MOUSE	Prkar2b	physical	10862698
KPCB_MOUSE	Prkcb	physical	10862698
KPCG_MOUSE	Prkcg	physical	10862698
KPCE_MOUSE	Prkce	physical	10862698
KCC2B_MOUSE	Camk2b	physical	10862698
PP1G_MOUSE	Ppp1cc	physical	10862698
PP2AA_MOUSE	Ppp2ca	physical	10862698
PP2BA_MOUSE	Ppp3ca	physical	10862698
PPP5_MOUSE	Ppp5c	physical	10862698
PTN11_MOUSE	Ptpn11	physical	10862698
SRC_MOUSE	Src	physical	10862698
FAK2_MOUSE	Ptk2b	physical	10862698
MK01_MOUSE	Mapk1	physical	10862698
MK03_MOUSE	Mapk3	physical	10862698
MP2K1_MOUSE	Map2k1	physical	10862698
MP2K2_MOUSE	Map2k2	physical	10862698
DUS4_MOUSE	Dusp4	physical	10862698
KS6A1_MOUSE	Rps6ka1	physical	10862698
KS6A3_MOUSE	Rps6ka3	physical	10862698
RAF1_MOUSE	Raf1	physical	10862698
RAC1_MOUSE	Rac1	physical	10862698
RAP1A_MOUSE	Rap1a	physical	10862698
NF1_MOUSE	Nf1	physical	10862698
P85A_MOUSE	Pik3r1	physical	10862698
PLCG1_MOUSE	Plcg1	physical	10862698
PA24A_MOUSE	Pla2g4a	physical	10862698
ARC_MOUSE	Arc	physical	10862698
CADH2_MOUSE	Cdh2	physical	10862698
DSG1A_MOUSE	Dsg1a	physical	10862698
CTNB1_MOUSE	Ctnnb1	physical	10862698
CTND1_MOUSE	Ctnnd1	physical	10862698
MTAP2_MOUSE	Map2	physical	10862698
ACTC_MOUSE	Actc1	physical	10862698
ACTN2_MOUSE	Actn2	physical	10862698
SPTA1_MOUSE	Spta1	physical	10862698
TBA1A_MOUSE	Tuba1a	physical	10862698
SRC8_MOUSE	Cttn	physical	10862698
CLH1_MOUSE	Cltc	physical	10862698
DYN1_MOUSE	Dnm1	physical	10862698
HS71B_MOUSE	Hspa1b	physical	10862698
BSN_MOUSE	Bsn	physical	10862698
MYH10_MOUSE	Myh10	physical	10862698
TP53B_MOUSE	Trp53bp1	physical	10862698
ZO1_MOUSE	Tjp1	physical	10862698
DLG1_MOUSE	Dlg1	physical	10862698
PFKAL_MOUSE	Pfkl	physical	10862698
DP13A_MOUSE	Appl1	physical	10862698
SLMAP_MOUSE	Slmap	physical	10862698
HSP7C_MOUSE	Hspa8	physical	10862698
AINX_MOUSE	Ina	physical	10862698
KCC2A_MOUSE	Camk2a	physical	10862698
FUS_MOUSE	Fus	physical	10862698
TBA4A_MOUSE	Tuba4a	physical	10862698
NMDE1_MOUSE	Grin2a	physical	9003035
NMDE2_MOUSE	Grin2b	physical	9003035
NMDE1_MOUSE	Grin2a	physical	16554481
NMDE2_MOUSE	Grin2b	physical	16554481
NMDE1_MOUSE	Grin2a	physical	14645471
NMDE2_MOUSE	Grin2b	physical	14645471
NMDE1_MOUSE	Grin2a	physical	15663482
NMDE2_MOUSE	Grin2b	physical	15663482
DLG4_MOUSE	Dlg4	physical	15663482
AP2A_MOUSE	Tfap2a	physical	15663482
LRP1_MOUSE	Lrp1	physical	23760271

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NMDZ1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-890, AND MASSSPECTROMETRY.	17114649 [Abstract]

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