DUS4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUS4_MOUSE
• UniProt AC: Q8BFV3
• Protein Name: Dual specificity protein phosphatase 4
• Gene Name: Dusp4
• Organism: Mus musculus (Mouse).
• Sequence Length: 398
• Subcellular Localization: Nucleus .
• Protein Description: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2..
• Protein Sequence: MVTMEELREMDCSVLKRLMNRDENGGGGSAGGNGSGSHGALGLLSGGKCLLLDCRPFLAHSAGYIRGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSTNESLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLTTSCAAEAASPSGPLRERGKATPTPTSQFVFSFPVSVGVHAAPSNLPYLHSPITTSPSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MVTMEELRE ------CCCHHHHHH	7.59	-
84	Phosphorylation	VRRRAKGSVSLEQIL HHCCCCCCCCHHHHC	14.07	28066266
86	Phosphorylation	RRAKGSVSLEQILPA CCCCCCCCHHHHCCC	28.08	28066266
361	Phosphorylation	LRERGKATPTPTSQF CHHCCCCCCCCCCCE	31.05	-
363	Phosphorylation	ERGKATPTPTSQFVF HCCCCCCCCCCCEEE	34.54	-
390	Phosphorylation	SNLPYLHSPITTSPS CCCCCCCCCCCCCCC	18.53	-
395	Phosphorylation	LHSPITTSPSC---- CCCCCCCCCCC----	13.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
361	T	Phosphorylation	Kinase	ERK1	P27361	PSP
363	T	Phosphorylation	Kinase	ERK1	P27361	PSP
390	S	Phosphorylation	Kinase	ERK1	P27361	PSP
390	S	Phosphorylation	Kinase	MAPK	-	Uniprot
395	S	Phosphorylation	Kinase	ERK1	P27361	PSP
395	S	Phosphorylation	Kinase	MAPK	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DUS4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUS4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DUS4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.