PPP5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPP5_MOUSE
• UniProt AC: Q60676
• Protein Name: Serine/threonine-protein phosphatase 5
• Gene Name: Ppp5c
• Organism: Mus musculus (Mouse).
• Sequence Length: 499
• Subcellular Localization: Nucleus . Cytoplasm . Cell membrane . Predominantly nuclear. But also present in the cytoplasm. Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner.
• Protein Description: Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2..
• Protein Sequence: MAMAEGERTECAETPRDEPPADGTLKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPGNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPNDKDAKMKYQECSKIVKQKAFERAIAGDEHRRSVVDSLDIESMTIEDEYSGPKLEDGKVTITFMKDLMQWYKDQKKLHRKCAYQILVQVKEVLCKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENQLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYANTLLQLGMM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAMAEGERT ------CCCCCCCCC	13.09	-
40	Acetylation	TQANDYFKAKDYENA HHHHHHHHHCCHHHH	48.58	22826441
77	S-nitrosocysteine	LAYLRTECYGYALGD CEEEHHHCCCHHCCC	2.93	-
77	Glutathionylation	LAYLRTECYGYALGD CEEEHHHCCCHHCCC	2.93	24333276
77	S-nitrosylation	LAYLRTECYGYALGD CEEEHHHCCCHHCCC	2.93	22178444
97	Malonylation	ELDKKYIKGYYRRAA HHCHHHHHHHHHHHH	37.46	26320211
105	Phosphorylation	GYYRRAASNMALGKF HHHHHHHHHHHHHHH	26.59	-
111	Acetylation	ASNMALGKFRAALRD HHHHHHHHHHHHHCC	32.31	22826441
119	Phosphorylation	FRAALRDYETVVKVK HHHHHCCCEEEEEEC	13.68	25367039
130	Acetylation	VKVKPNDKDAKMKYQ EEECCCCHHHHHHHH	67.25	23201123
135	Malonylation	NDKDAKMKYQECSKI CCHHHHHHHHHHHHH	42.97	26320211
139	Glutathionylation	AKMKYQECSKIVKQK HHHHHHHHHHHHHHH	2.72	24333276
404	S-nitrosocysteine	VSKRGVSCQFGPDVT CHHCCCCCCCCCCHH	3.45	-
404	Glutathionylation	VSKRGVSCQFGPDVT CHHCCCCCCCCCCHH	3.45	24333276
404	S-nitrosylation	VSKRGVSCQFGPDVT CHHCCCCCCCCCCHH	3.45	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPP5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPP5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPP5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPNE1_HUMAN	CPNE1	physical	12522145
CPNE4_HUMAN	CPNE4	physical	12522145
CDC27_HUMAN	CDC27	physical	9405394
CDC16_HUMAN	CDC16	physical	9405394

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.