AKAP5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKAP5_MOUSE
• UniProt AC: D3YVF0
• Protein Name: A-kinase anchor protein 5
• Gene Name: Akap5
• Organism: Mus musculus (Mouse).
• Sequence Length: 745
• Subcellular Localization: Membrane; Lipid-anchor. Associates with lipid rafts..
• Protein Description: May anchor the PKA kinase to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors..
• Protein Sequence: METSVSEIQVETKDEKGPVAASPQKERQERKTATLCFKRRKKANKTKPKAGSRTAEETKKHTPEAGGSGQRQPAGAWASIKGLVTHRKRSEPAKKQKPPEAEVQPEDGALPKKKAKSRLKFPCLRFSRGAKRSRHSKLTEDSGYVRVQGEADDLEIKAQTQPDDQAIQAGSTQGLQEGVLVRDGKKSQESHISNSVTSGENVIAIELELENKSSAIQMGTPELEKETKVITEKPSVQTQRASLLESSAAGSPRSVTSAAPPSPATTHQHSLEEPSNGIRESAPSGKDDRRKTAAEEKKSGETALGQAEEAAVGQADKRALSQAGEATAGHPEEATVIQAESQAKEGKLSQAEETTVAQAKETVLSQAKEGELSQAKKATVGQAEEATIDHTEKVTVDQAEETTVGQAEEATVGQAGEAILSQAKEATVVGQAEEATVDRAEEATVGQAEEATVGHTEKVTVDQAEEATVGQAEEATVGQAEEATVDWAEKPTVGQAEEATVGQAEEATVGHTEKVTVDQAEEATVGQAEEATVGHTEKVTVDHAEEATVGQAEEATVGQAEKVTVDHAEEATVGQAEEATVGQAEKVTVDHAEEATVGQAEEATVGQAEKVTVDQAEEPTVDQAEEAISSHAPDLKENGIDTEKPRSEESKRMEPIAIIITDTEISEFDVKKSKNVPKQFLISMENEQVGVFANDSDFEGRTSEQYETLLIETASSLVKNAIELSVEQLVNEMVSEDNQINTLFQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----METSVSEIQV -----CCCCCCEEEE	32.88	29899451
4	Phosphorylation	----METSVSEIQVE ----CCCCCCEEEEE	15.44	19060867
6	Phosphorylation	--METSVSEIQVETK --CCCCCCEEEEEEC	28.84	21183079
22	Phosphorylation	EKGPVAASPQKERQE CCCCCCCCCHHHHHH	20.37	25521595
36	S-palmitoylation	ERKTATLCFKRRKKA HHHHHHHHHHHHHHC	3.08	30355502
52	Phosphorylation	KTKPKAGSRTAEETK CCCCCCCCCCHHHHH	31.17	29899451
54	Phosphorylation	KPKAGSRTAEETKKH CCCCCCCCHHHHHCC	39.87	29899451
62	Phosphorylation	AEETKKHTPEAGGSG HHHHHCCCCCCCCCC	31.53	29899451
68	Phosphorylation	HTPEAGGSGQRQPAG CCCCCCCCCCCCCCC	30.73	25521595
79	Phosphorylation	QPAGAWASIKGLVTH CCCCCHHHHHHHHHC	17.71	25521595
123	S-palmitoylation	KSRLKFPCLRFSRGA HHCCCCCHHHCCCCC	4.85	30355502
142	Phosphorylation	HSKLTEDSGYVRVQG CCCCCCCCCCEEEEE	26.28	19060867
144	Phosphorylation	KLTEDSGYVRVQGEA CCCCCCCCEEEEEEE	6.77	23140645
171	Phosphorylation	DQAIQAGSTQGLQEG CHHHHCCCCCCCCCC	22.15	25521595
172	Phosphorylation	QAIQAGSTQGLQEGV HHHHCCCCCCCCCCE	26.24	29899451
220	Phosphorylation	SSAIQMGTPELEKET CCCCCCCCHHHHHHC	14.30	25521595
242	Phosphorylation	SVQTQRASLLESSAA CHHHHHHHHHHHHCC	35.36	28978645
246	Phosphorylation	QRASLLESSAAGSPR HHHHHHHHHCCCCCC	25.83	28066266
247	Phosphorylation	RASLLESSAAGSPRS HHHHHHHHCCCCCCC	16.86	24925903
251	Phosphorylation	LESSAAGSPRSVTSA HHHHCCCCCCCCCCC	16.65	25521595
256	Phosphorylation	AGSPRSVTSAAPPSP CCCCCCCCCCCCCCC	17.56	30372032
257	Phosphorylation	GSPRSVTSAAPPSPA CCCCCCCCCCCCCCC	21.93	30372032
262	Phosphorylation	VTSAAPPSPATTHQH CCCCCCCCCCCCCCC	26.55	19060867
266	Phosphorylation	APPSPATTHQHSLEE CCCCCCCCCCCCCCC	22.96	30372032
270	Phosphorylation	PATTHQHSLEEPSNG CCCCCCCCCCCCCCC	30.79	30372032
349	Phosphorylation	QAKEGKLSQAEETTV HHHCCCCCHHHHHHH	30.72	16302743
354	Phosphorylation	KLSQAEETTVAQAKE CCCHHHHHHHHHHHH	20.34	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKAP5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
36	C	Palmitoylation	Palmitoylation at Cys-36 and Cys-123 play a key role in the targeting of AKAP5 to lipid rafts.	-
123	C	Palmitoylation	Palmitoylation at Cys-36 and Cys-123 play a key role in the targeting of AKAP5 to lipid rafts.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKAP5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AKAP5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.