PP1G_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PP1G_MOUSE
• UniProt AC: P63087
• Protein Name: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
• Gene Name: Ppp1cc
• Organism: Mus musculus (Mouse).
• Sequence Length: 323
• Subcellular Localization: Cytoplasm . Nucleus . Cleavage furrow . Nucleus, nucleolus . Nucleus, nucleoplasm . Chromosome, centromere, kinetochore . Nucleus speckle . Midbody . Mitochondrion . Colocalizes with SPZ1 in the nucleus (PubMed:15226296). Colocalizes with URI1 at mit
• Protein Description: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E.; Isoform 2: Required for normal male fertility..
• Protein Sequence: MADIDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADIDKLNI ------CCCHHHCCH	23.59	-
22	Phosphorylation	RLLEVRGSKPGKNVQ HHHHHHCCCCCCCCC	25.72	29514104
26	Ubiquitination	VRGSKPGKNVQLQEN HHCCCCCCCCCCCCC	63.57	-
42	Phosphorylation	IRGLCLKSREIFLSQ HHHHHHHCHHHHHCC	23.38	26745281
48	Phosphorylation	KSREIFLSQPILLEL HCHHHHHCCCEEEEE	24.14	26745281
98	Ubiquitination	GDYVDRGKQSLETIC HHHCHHCHHHHHHHH	37.29	-
113	Ubiquitination	LLLAYKIKYPENFFL HHHHHHCCCCCCEEE	51.07	-
129	Phosphorylation	RGNHECASINRIYGF CCCCHHHHHHHHEEC	31.86	23684622
137	Phosphorylation	INRIYGFYDECKRRY HHHHEECHHHHHHHH	13.38	-
141	Acetylation	YGFYDECKRRYNIKL EECHHHHHHHHCCCC	37.55	15079803
141	Ubiquitination	YGFYDECKRRYNIKL EECHHHHHHHHCCCC	37.55	-
147	Ubiquitination	CKRRYNIKLWKTFTD HHHHHCCCCCHHHHH	44.66	-
150	Ubiquitination	RYNIKLWKTFTDCFN HHCCCCCHHHHHHCC	44.17	-
151	Phosphorylation	YNIKLWKTFTDCFNC HCCCCCHHHHHHCCC	21.86	23984901
153	Phosphorylation	IKLWKTFTDCFNCLP CCCCHHHHHHCCCCH	36.77	23984901
171	S-palmitoylation	IVDEKIFCCHGGLSP HCCCCEEECCCCCCC	1.58	28680068
172	S-palmitoylation	VDEKIFCCHGGLSPD CCCCEEECCCCCCCC	2.02	28680068
182	Phosphorylation	GLSPDLQSMEQIRRI CCCCCHHHHHHHHHH	31.42	28464351
260	Ubiquitination	DGYEFFAKRQLVTLF HCHHHHHHCCEEECC	35.20	-
260	Acetylation	DGYEFFAKRQLVTLF HCHHHHHHCCEEECC	35.20	19809439
307	Phosphorylation	EKKKPNATRPVTPPR HCCCCCCCCCCCCCC	41.99	25159016
311	Phosphorylation	PNATRPVTPPRGMIT CCCCCCCCCCCCCCC	30.20	25159016
317 (in isoform 2)	Phosphorylation	-	4.91	30352176
319	Ubiquitination	PPRGMITKQAKK--- CCCCCCCCCCCC---	37.02	-
329 (in isoform 2)	Phosphorylation	-		29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PP1G_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PP1G_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PP1G_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL2_MOUSE	Bcl2	physical	17274640
EIF2A_MOUSE	Eif2a	physical	17274640
CDN2A_MOUSE	Cdkn2a	physical	17274640
ARF_MOUSE	Cdkn2a	physical	17274640
RB_MOUSE	Rb1	physical	17274640
B2CL1_MOUSE	Bcl2l1	physical	17274640
UB2R1_MOUSE	Cdc34	physical	17274640
CDK1_MOUSE	Cdk1	physical	17274640
CDK2_MOUSE	Cdk2	physical	17274640
CDK4_MOUSE	Cdk4	physical	17274640
CCNB1_MOUSE	Ccnb1	physical	17274640
CCND1_MOUSE	Ccnd1	physical	17274640
CCND3_MOUSE	Ccnd3	physical	17274640
HS71B_MOUSE	Hspa1b	physical	17274640
SKP1_MOUSE	Skp1a	physical	17274640
PCNA_MOUSE	Pcna	physical	17274640
STX1A_MOUSE	Stx1a	physical	17274640
ESR1_MOUSE	Esr1	physical	17274640
P53_MOUSE	Trp53	physical	17274640
BAX_MOUSE	Bax	physical	17274640
EGFR_MOUSE	Egfr	physical	17274640
GSK3A_MOUSE	Gsk3a	physical	17274640
TS101_MOUSE	Tsg101	physical	17274640
WBP11_MOUSE	Wbp11	physical	14640981

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.