TS101_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TS101_MOUSE
• UniProt AC: Q61187
• Protein Name: Tumor susceptibility gene 101 protein
• Gene Name: Tsg101
• Organism: Mus musculus (Mouse).
• Sequence Length: 391
• Subcellular Localization: Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Late endosome membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody, Midbody ring . Nucleus . Mainl
• Protein Description: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity)..
• Protein Sequence: MAVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYRGNIYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHDWKHPRSELLELIQIMIVIFGEEPPVFSRPTVSASYPPYTATGPPNTSYMPGMPSGISAYPSGYPPNPSGYPGCPYPPAGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDGAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVSESQLK ------CCCCHHHHH	17.34	-
9	Malonylation	AVSESQLKKMMSKYK CCCHHHHHHHHHHHC	30.87	26320211
10	Acetylation	VSESQLKKMMSKYKY CCHHHHHHHHHHHCC	48.72	21728379
25	Phosphorylation	RDLTVRQTVNVIAMY CCCCHHHHHHHHEEE	11.95	27180971
36	Ubiquitination	IAMYKDLKPVLDSYV HEEECCHHHHHHEEE	43.12	-
41	Phosphorylation	DLKPVLDSYVFNDGS CHHHHHHEEEECCCC	21.02	25293948
42	Phosphorylation	LKPVLDSYVFNDGSS HHHHHHEEEECCCCC	14.55	25293948
48	Phosphorylation	SYVFNDGSSRELVNL EEEECCCCCCEEEEE	29.14	26370283
92	Phosphorylation	PICFVKPTSSMTIKT CEEEECCCCCCEEEC	27.93	28576409
221	Phosphorylation	VGPSRDGTISEDTIR ECCCCCCCCCHHHHH	26.14	26824392
223	Phosphorylation	PSRDGTISEDTIRAS CCCCCCCCHHHHHHH	29.29	23737553
238	Ubiquitination	LISAVSDKLRWRMKE HHHHHHHHHHHHHHH	32.23	-
244	Ubiquitination	DKLRWRMKEEMDGAQ HHHHHHHHHHHCHHH	41.78	-
310	Phosphorylation	LEKMENQSENNDIDE HHHHHHCCCCCCCCC	54.60	22817900
362	Ubiquitination	IDLDVFLKHVRLLSR CCHHHHHHHHHHHCH	28.70	-
380	Malonylation	QLRALMQKARKTAGL HHHHHHHHHHHHCCC	35.87	26320211
388	Phosphorylation	ARKTAGLSDLY---- HHHHCCCCCCC----	25.34	24719451
391	Phosphorylation	TAGLSDLY------- HCCCCCCC-------	22.84	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Lrsam1	Q80ZI6	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Mgrn1	Q9D074	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TS101_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TS101_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TS101_MOUSE	Tsg101	physical	20211142
MGRN1_MOUSE	Mgrn1	physical	19703557
CXG1_MOUSE	Gjc1	physical	19210987
CXA1_MOUSE	Gja1	physical	19210987
CXB3_MOUSE	Gjb3	physical	19210987
CAV1_HUMAN	CAV1	physical	26496610
FLOT2_HUMAN	FLOT2	physical	26496610
RAI3_HUMAN	GPRC5A	physical	26496610
IST1_HUMAN	IST1	physical	26496610
ERLN1_HUMAN	ERLIN1	physical	26496610
CHM2B_HUMAN	CHMP2B	physical	26496610
VPS28_HUMAN	VPS28	physical	26496610
UBAP1_HUMAN	UBAP1	physical	26496610
CHMP5_HUMAN	CHMP5	physical	26496610
CHMP3_HUMAN	CHMP3	physical	26496610
VP37C_HUMAN	VPS37C	physical	26496610
VP37B_HUMAN	VPS37B	physical	26496610
CYBR1_HUMAN	CYBRD1	physical	26496610
MB12A_HUMAN	MVB12A	physical	26496610
CHM4B_HUMAN	CHMP4B	physical	26496610
VP37A_HUMAN	VPS37A	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.