CXG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXG1_MOUSE
• UniProt AC: P28229
• Protein Name: Gap junction gamma-1 protein
• Gene Name: Gjc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 396
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
• Protein Description: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell..
• Protein Sequence: MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSISSKSGDGKTSVWI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
148	Phosphorylation	YPEMELESEKENKEQ CCHHHHHHHHHHHHC	67.60	25338131
324	Phosphorylation	NIAQEQQYGSHEEHL HHHHHHHHCCCCCCC	21.93	29514104
326	Phosphorylation	AQEQQYGSHEEHLPA HHHHHHCCCCCCCCC	23.85	27742792
337	Phosphorylation	HLPADLETLQREIRM CCCCCHHHHHHHHHH	35.17	22127232
376	Phosphorylation	KAKVGSKSGSNKSSI CCCCCCCCCCCCHHC	49.50	29514104
381	Phosphorylation	SKSGSNKSSISSKSG CCCCCCCHHCCCCCC	36.84	22127232
382	Phosphorylation	KSGSNKSSISSKSGD CCCCCCHHCCCCCCC	28.26	22127232
384	Phosphorylation	GSNKSSISSKSGDGK CCCCHHCCCCCCCCC	33.39	22127232
385	Phosphorylation	SNKSSISSKSGDGKT CCCHHCCCCCCCCCE	29.21	22127232
387	Phosphorylation	KSSISSKSGDGKTSV CHHCCCCCCCCCEEE	44.03	22127232
393	Phosphorylation	KSGDGKTSVWI---- CCCCCCEEECC----	20.95	22127232

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
326	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
326	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
337	T	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
381	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
382	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
382	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
384	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
384	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
385	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
387	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
387	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
393	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
393	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXG1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXG1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TS101_MOUSE	Tsg101	physical	19210987

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.