CCNB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCNB1_MOUSE
• UniProt AC: P24860
• Protein Name: G2/mitotic-specific cyclin-B1
• Gene Name: Ccnb1
• Organism: Mus musculus (Mouse).
• Sequence Length: 430
• Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
• Protein Description: Essential for the control of the cell cycle at the G2/M (mitosis) transition..
• Protein Sequence: MALRVTRNTKINAENKAKVSMAGAKRVPVTVTAASKPGLRPRTALGDIGNKVSEELQARVPLKREAKTLGTGKGTVKALPKPVEKVPVCEPEVELAEPEPEPELEHVREEKLSPEPILVDNPSPSPMETSGCAPAEEYLCQAFSDVILAVSDVDADDGADPNLCSEYVKDIYAYLRQLEEEQSVRPKYLQGREVTGNMRAILIDWLIQVQMKFRLLQETMYMTVSIIDRFMQNSCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTNNTYTKHQIRQMEMKILRVLNFSLGRPLPLHFLRRASKVGEVDVEQHTLAKYLMELSMLDYDMVHFAPSQIAAGAFCLALKILDNGEWTPTLQHYLSYSEDSLLPVMQHLAKNVVMVNCGLTKHMTVKNKYAASKHAKISTLAQLNCTLVQNLSKAVTKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Acetylation	KVSMAGAKRVPVTVT EECCCCCCCCCEEEE	53.67	7395819
51	Ubiquitination	ALGDIGNKVSEELQA CCHHHCHHHCHHHHH	41.76	-
53	Phosphorylation	GDIGNKVSEELQARV HHHCHHHCHHHHHHC	27.28	22942356
73	Acetylation	AKTLGTGKGTVKALP HHHCCCCCCCCEECC	51.77	-
123	Phosphorylation	PILVDNPSPSPMETS CEEECCCCCCCCCCC	44.24	-
125	Phosphorylation	LVDNPSPSPMETSGC EECCCCCCCCCCCCC	41.01	-
130	Phosphorylation	SPSPMETSGCAPAEE CCCCCCCCCCCCHHH	20.69	-
144	Phosphorylation	EYLCQAFSDVILAVS HHHHHHHCCEEEEEE	33.70	22817900
254	Acetylation	TAMFIASKYEEMYPP HHHHHHHCHHHHCCC	47.89	15607971
318	Phosphorylation	EVDVEQHTLAKYLME CCCHHHHHHHHHHHH	28.27	-
425	Ubiquitination	TLVQNLSKAVTKA-- HHHHHHHHHHHCC--	50.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
123	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot
130	S	Phosphorylation	Kinase	PLK1	Q07832	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Cdc20	Q9JJ66	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Fzr1	Q9R1K5	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Zc3hc1	Q80YV2	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
130	S	Phosphorylation	Phosphorylated by PLK1 at Ser-130 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import.	-
130	S	Phosphorylation	Phosphorylation at Ser-144 was also reported to be mediated by PLK1 but Ser-130 seems to be the primary phosphorylation site (By similarity).	-
144	S	Phosphorylation	Phosphorylation at Ser-144 was also reported to be mediated by PLK1 but Ser-130 seems to be the primary phosphorylation site (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCNB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDK1_MOUSE	Cdk1	physical	19553603
CDK1_MOUSE	Cdk1	physical	12121977
CDK1_MOUSE	Cdk1	physical	10559244
H11_MOUSE	Hist1h1a	physical	9247342
CDK1_MOUSE	Cdk1	physical	9247342

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.