dbPTM

STX1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STX1A_MOUSE
UniProt AC	O35526
Protein Name	Syntaxin-1A
Gene Name	Stx1a
Organism	Mus musculus (Mouse).
Sequence Length	288
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Single-pass type IV membrane protein . Cell junction, synapse, synaptosome . Cell membrane . Colocalizes with KCNB1 at the cell membrane.
Protein Description	Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [PubMed: 15774481]
Protein Sequence	MKDRTQELRTAKDSDDDDDVTVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHSEIIKLETSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIIIASTIGGIFG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	DRTQELRTAKDSDDD HHHHHHHHCCCCCCC	51.16	24925903
12	Ubiquitination	TQELRTAKDSDDDDD HHHHHHCCCCCCCCC	58.09	22790023
14	Phosphorylation	ELRTAKDSDDDDDVT HHHHCCCCCCCCCCE	42.08	25521595
21	Phosphorylation	SDDDDDVTVTVDRDR CCCCCCCEEEEEHHH	19.90	27841257
23	Phosphorylation	DDDDVTVTVDRDRFM CCCCCEEEEEHHHHH	13.81	24925903
46	Ubiquitination	EIRGFIDKIAENVEE HHHHHHHHHHHCHHH	38.71	22790023
59	Phosphorylation	EEVKRKHSAILASPN HHHHHHHHHHHCCCC	21.75	25521595
64	Phosphorylation	KHSAILASPNPDEKT HHHHHHCCCCCCHHH	23.05	25521595
70	Ubiquitination	ASPNPDEKTKEELEE CCCCCCHHHHHHHHH	72.74	22790023
80	Phosphorylation	EELEELMSDIKKTAN HHHHHHHHHHHHHHH	49.13	29899451
94	Ubiquitination	NKVRSKLKSIEQSIE HHHHHHHHHHHHHHH	53.80	22790023
95	Phosphorylation	KVRSKLKSIEQSIEQ HHHHHHHHHHHHHHH	41.62	25521595
99	Phosphorylation	KLKSIEQSIEQEEGL HHHHHHHHHHHHHCC	18.46	29899451
109	Phosphorylation	QEEGLNRSSADLRIR HHHCCCCCHHHHHHH	28.89	22807455
110	Phosphorylation	EEGLNRSSADLRIRK HHCCCCCHHHHHHHH	23.67	25521595
159	Phosphorylation	QLEITGRTTTSEELE HHHHHCCCCCHHHHH	35.45	20415495
160	Phosphorylation	LEITGRTTTSEELED HHHHCCCCCHHHHHH	27.28	29899451
161	Phosphorylation	EITGRTTTSEELEDM HHHCCCCCHHHHHHH	33.26	29899451
162	Phosphorylation	ITGRTTTSEELEDML HHCCCCCHHHHHHHH	27.29	29899451
171	Phosphorylation	ELEDMLESGNPAIFA HHHHHHHHCCCCHHH	39.65	29899451
188	Phosphorylation	IIMDSSISKQALSEI EEECCCHHHHHHHHH	22.21	-
197	Phosphorylation	QALSEIETRHSEIIK HHHHHHHHHHHHHHH	39.07	29899451
200	Phosphorylation	SEIETRHSEIIKLET HHHHHHHHHHHHHHH	27.48	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
188	S	Phosphorylation	Kinase	DAPK1	Q80YE7	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
188	S	Phosphorylation		-
Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1 (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STX1A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX1A_MOUSE	Stx1a	physical	21151134
SNP25_MOUSE	Snap25	physical	21151134
VAMP2_MOUSE	Vamp2	physical	21151134
SNP25_MOUSE	Snap25	physical	16269331
VAMP2_MOUSE	Vamp2	physical	16269331
CAC1D_MOUSE	Cacna1d	physical	10468580
STXB2_MOUSE	Stxbp2	physical	7890599
STXB1_MOUSE	Stxbp1	physical	7890599
VAMP2_MOUSE	Vamp2	physical	20114047
SNP25_MOUSE	Snap25	physical	20114047
STXB1_MOUSE	Stxbp1	physical	20114047
KCMA1_MOUSE	Kcnma1	physical	20114047
SC22B_MOUSE	Sec22b	physical	24705552

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STX1A_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND MASSSPECTROMETRY.	17114649 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND MASSSPECTROMETRY.	16452087 [Abstract]

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