dbPTM

VAMP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VAMP2_MOUSE
UniProt AC	P63044
Protein Name	Vesicle-associated membrane protein 2
Gene Name	Vamp2
Organism	Mus musculus (Mouse).
Sequence Length	116
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane . Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles.
Protein Description	Involved in the targeting and/or fusion of transport vesicles to their target membrane. [PubMed: 9430681 Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity]
Protein Sequence	MSATAATVPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSATAATVP ------CCCCCCCCC	34.03	-
2	Phosphorylation	------MSATAATVP ------CCCCCCCCC	34.03	29514104
35	Phosphorylation	SNRRLQQTQAQVDEV CCHHHHHHHHHHHHH	16.95	19962314
52	Ubiquitination	IMRVNVDKVLERDQK HHHCCHHHHHHHHHH	44.42	-
59	Ubiquitination	KVLERDQKLSELDDR HHHHHHHHHHHHHHH	59.26	-
61	Phosphorylation	LERDQKLSELDDRAD HHHHHHHHHHHHHHH	43.05	25521595
75	Phosphorylation	DALQAGASQFETSAA HHHHHHHHHHHHHHH	34.19	25521595
79	Phosphorylation	AGASQFETSAAKLKR HHHHHHHHHHHHHHH	25.59	27742792
80	Phosphorylation	GASQFETSAAKLKRK HHHHHHHHHHHHHHH	21.02	25521595
83	Ubiquitination	QFETSAAKLKRKYWW HHHHHHHHHHHHHHH	55.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
35	T	Phosphorylation	Kinase	ATR	Q9JKK8	PSP
61	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VAMP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VAMP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNP25_MOUSE	Snap25	physical	21151134
STX1A_MOUSE	Stx1a	physical	21151134
STX1A_MOUSE	Stx1a	physical	20798282
SYUA_MOUSE	Snca	physical	20798282
SNP25_MOUSE	Snap25	physical	20798282
SNP25_MOUSE	Snap25	physical	16269331
STX1A_MOUSE	Stx1a	physical	16269331
SNP25_MOUSE	Snap25	physical	20114047
STX1A_MOUSE	Stx1a	physical	20114047
DYN1_MOUSE	Dnm1	physical	20114047
SYPH_MOUSE	Syp	physical	20114047
GPM6A_MOUSE	Gpm6a	physical	20114047
STX1B_MOUSE	Stx1b	physical	20114047
SNAB_MOUSE	Napb	physical	20114047
GBB3_MOUSE	Gnb3	physical	20114047
GBB1_MOUSE	Gnb1	physical	20114047
GNAO_MOUSE	Gnao1	physical	20114047
VA0D1_MOUSE	Atp6v0d1	physical	20114047
ZNT3_MOUSE	Slc30a3	physical	20114047
AT1A2_MOUSE	Atp1a2	physical	20114047
AT1A3_MOUSE	Atp1a3	physical	20114047
AT1A1_MOUSE	Atp1a1	physical	20114047
LYST_HUMAN	LYST	physical	26496610
STX7_HUMAN	STX7	physical	26496610
RTL8C_HUMAN	FAM127A	physical	26496610
ARHGH_HUMAN	ARHGEF17	physical	26496610
OSBL2_HUMAN	OSBPL2	physical	26496610
DJC13_HUMAN	DNAJC13	physical	26496610
DDX6L_HUMAN	DDX60L	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VAMP2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75, AND MASSSPECTROMETRY.	17114649 [Abstract]