GPM6A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPM6A_MOUSE
• UniProt AC: P35802
• Protein Name: Neuronal membrane glycoprotein M6-a
• Gene Name: Gpm6a
• Organism: Mus musculus (Mouse).
• Sequence Length: 278
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Cell projection, dendritic spine. Cell projection, filopodium. Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane
• Protein Description: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. Conflictingly, PubMed:22162747 reports that induced cellular protrusions are simple membrane-wrapped tubules without actin or tubulin-based cytoskeletons and with Gpm6a gliding along membrane edges indicative for a function in actin-independent membrane deformation. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor..
• Protein Sequence: MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFELARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNVWTICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTASENFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNAYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEENMEEG -------CCCCCCCC	15.27	-
14	S-palmitoylation	EGQTQKGCFECCIKC CCCCCCCHHHHHHHH	3.15	28680068
17	S-palmitoylation	TQKGCFECCIKCLGG CCCCHHHHHHHHHCC	1.14	28680068
18	S-palmitoylation	QKGCFECCIKCLGGI CCCHHHHHHHHHCCC	2.34	28680068
122	S-palmitoylation	GDFKITTCGRCVSAW CCCEECCCHHHHHHH	2.12	28680068
164	N-linked_Glycosylation	NVWTICRNTTLVEGA CHHHHCCCCCCCCCC	32.76	-
192	S-palmitoylation	IGEEKKICTASENFL ECCCCCEECCCHHHH	3.41	28526873
192	S-nitrosylation	IGEEKKICTASENFL ECCCCCEECCCHHHH	3.41	22588120
208	N-linked_Glycosylation	MCESTELNMTFHLFI HHHCCCCHHHHHHHH	22.63	-
250	Ubiquitination	KDACRMQKYEDIKSK HHHHHCCCHHHHCCH	41.06	22790023
251	Phosphorylation	DACRMQKYEDIKSKE HHHHCCCHHHHCCHH	11.27	22817900
255	Ubiquitination	MQKYEDIKSKEEQEL CCCHHHHCCHHHHHH	68.73	22790023
256	Phosphorylation	QKYEDIKSKEEQELH CCHHHHCCHHHHHHH	45.71	24925903
257	Ubiquitination	KYEDIKSKEEQELHD CHHHHCCHHHHHHHH	61.34	22790023
267	Phosphorylation	QELHDIHSTRSKERL HHHHHHHHHCCHHHH	26.33	25521595
268	Phosphorylation	ELHDIHSTRSKERLN HHHHHHHHCCHHHHH	25.46	25521595
270	Phosphorylation	HDIHSTRSKERLNAY HHHHHHCCHHHHHCC	38.67	25521595
278	Phosphorylation	KERLNAYT------- HHHHHCCC-------	29.71	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPM6A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPM6A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPM6A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GPM6A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.