DDX6L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX6L_HUMAN
• UniProt AC: Q5H9U9
• Protein Name: Probable ATP-dependent RNA helicase DDX60-like
• Gene Name: DDX60L
• Organism: Homo sapiens (Human).
• Sequence Length: 1706
• Protein Sequence: MGSKDHAVFFREMTQLILNEMPKAGYSSILNDFVESNFFVIDGDSLLVTCLGVKSFKWGQNLHFFYLVECYLVDLLSNGGQFTIVFFKDAEYAYFDFPELLSLRTALILHLQHNTNIDVQTEFSGCLSQDWKLFLEQHYPYFLIVSEEGLSDLQTYLFNFLIIHSWGMKVNVVLSSGHESDTLRFYAYTMESTDRNQTFSKENETVIQSAYKSLIQHLEEIRVLVLATHFEHLKWNDMMEEAYQTLFLLQHLWSEGSDIQRVLCVTSCSLSLRMYHRVLVHSNCLSLQEVEDFCRLRCLCVAFQLHLPLSQRACSRVITCSWIRNSDSFLKMNKWCEYFILSNLNVFGCWNLNLNHVSDLYDEQLLKNIAFYYEFESTQEPHLNLGDSIRRDYEDLWNVVSHLVKEFNVGKSFPLRTTRRHFLRQEKSVIQEISLEKMPSVGFIPMTSAVIDEFVGDMMKDLPILKSDDPVVPSLFKQKTSDELLHWHAQRLLSDDYDRIKCHVDEQSRDPHVLDFLKKIQDYQQFYGKSLESISTKVIVTQTTRPKEDSSGASGEILQNTKPHQITKKSKKKSFLKEDQNKAQQNDDLLFSIEEEMKNNLHSGIRKLEDYLTSCASNSVKFGVEMLGLIACFKAWKKHCRGEGKISKDLSIAVQMMKRIHSLLERYPEILEAEHHQYIAKCLKYLGFNDLANSLDPTLIGDDKNKKKYSIDIGPARFQLQYMGHYLIRDERKDRDPRVQDFIPNAWQQELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTLPAGRTLCGAFTRDYCHNVLNCQVLITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIRCPFLVLSATINNPNLLTKWLQSVKQYWKQADKIMEEKCISEKQADKCLNFLQDHSYKNQSYEVRLVLYGERYNDLEKHICSVKHDDVYFDHFHPCAALTTDIIEKYGFPPDLTLTPQESIQLYDTMAQVWETWPRAQELCPEEFILFKNKIVIKKLDARKYEENLKAELTNWIKNGQVKKVKRVLKNLSPDSLSSSKDMVKMFPLLVEKLRQMDKLPAIFFLFKNDDVGKRAGSVCTFLEKTETKSHPHTECHSYVFAIDEVLEKVRKTQKRITKKNPKKAEKLERKKVYRAEYINFLENLKILEISEDCTYADVKALHTEITRNKDSTLERVLPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGIHMPCKSVVFAQDSVYLDALNYRQMSGRAGRRGQDLLGNVYFFDIPLPKIKRLLASSVPELRGQFPLSITLVLRLMLLASKGDDPEDAKAKVLSVLKHSLLSFKRRRAMETLKLYFLFSLQLLIKEDYLNKKGNPKKFAGLASYLHGHEPSNLVFVNFLKRGLFHNLCKPAWKGSQQFSQDVMEKLVLVLANLFGRKYIPAKFQNANLSFSQSKVILAELPEDFKAALYEYNLAVMKDFASFLLIASKSVNMKKEHQLPLSRIKFTGKECEDSQLVSHLMSCKKGRVAISPFVCLSGNTDNDLLRPETINQVILRTVGVSGTQAPLLWPWKLDNRGRRMPLNAYVLNFYKHNCLTRLDQKNGMRMGQLLKCLKDFAFNIQAISDSLSELCENKRDNVVLAFKQLSQTFYEKLQEMQIQMSQNHLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MGSKDHAVFFR ----CCCHHHHHHHH	65.48	23000965
90	Ubiquitination	TIVFFKDAEYAYFDF EEEEECCCCCEECCH	16.58	22817900
92	Ubiquitination	VFFKDAEYAYFDFPE EEECCCCCEECCHHH	14.34	22817900
93	Ubiquitination	FFKDAEYAYFDFPEL EECCCCCEECCHHHH	7.04	22817900
94	Ubiquitination	FKDAEYAYFDFPELL ECCCCCEECCHHHHH	11.63	22817900
141	Phosphorylation	FLEQHYPYFLIVSEE HHHHHCCEEEEEECC	12.12	-
198	Phosphorylation	ESTDRNQTFSKENET CCCCCCCCCCHHHHH	33.16	-
200	Ubiquitination	TDRNQTFSKENETVI CCCCCCCCHHHHHHH	42.31	27667366
200	Phosphorylation	TDRNQTFSKENETVI CCCCCCCCHHHHHHH	42.31	-
201	Ubiquitination	DRNQTFSKENETVIQ CCCCCCCHHHHHHHH	61.44	22817900
205	Phosphorylation	TFSKENETVIQSAYK CCCHHHHHHHHHHHH	34.19	22210691
209	Phosphorylation	ENETVIQSAYKSLIQ HHHHHHHHHHHHHHH	23.57	28258704
211	Phosphorylation	ETVIQSAYKSLIQHL HHHHHHHHHHHHHHH	13.32	28258704
269	Phosphorylation	VLCVTSCSLSLRMYH HHHHHCCCCHHHHHH	22.29	17081983
271	Phosphorylation	CVTSCSLSLRMYHRV HHHCCCCHHHHHHHH	9.53	17081983
305	Ubiquitination	CLCVAFQLHLPLSQR HHHHHHHHCCCHHHH	3.46	27667366
326	Phosphorylation	TCSWIRNSDSFLKMN EEHHHHCCCCCHHHH	25.45	25690035
328	Phosphorylation	SWIRNSDSFLKMNKW HHHHCCCCCHHHHHH	32.09	24719451
428	Phosphorylation	HFLRQEKSVIQEISL HHHHHCCHHHHHHCH	24.57	24114839
434	Phosphorylation	KSVIQEISLEKMPSV CHHHHHHCHHCCCCC	29.71	24114839
440	Phosphorylation	ISLEKMPSVGFIPMT HCHHCCCCCCEEECC	31.23	26074081
447	Phosphorylation	SVGFIPMTSAVIDEF CCCEEECCHHHHHHH	14.26	26074081
448	Phosphorylation	VGFIPMTSAVIDEFV CCEEECCHHHHHHHH	17.81	26074081
466	Ubiquitination	MKDLPILKSDDPVVP HHCCCCCCCCCCCCH	53.19	22817900
467	Phosphorylation	KDLPILKSDDPVVPS HCCCCCCCCCCCCHH	43.74	26074081
474	Phosphorylation	SDDPVVPSLFKQKTS CCCCCCHHHHCCCCH	34.52	24719451
477	Ubiquitination	PVVPSLFKQKTSDEL CCCHHHHCCCCHHHH	57.06	21906983
477	Methylation	PVVPSLFKQKTSDEL CCCHHHHCCCCHHHH	57.06	-
479	Ubiquitination	VPSLFKQKTSDELLH CHHHHCCCCHHHHHH	51.06	22817900
501	Ubiquitination	SDDYDRIKCHVDEQS CCCCCHHEECCCCCC	21.12	29967540
529	Ubiquitination	DYQQFYGKSLESIST HHHHHHCCCHHHCCE	40.25	29967540
561	Phosphorylation	SGEILQNTKPHQITK CCHHHHCCCHHHCCH	32.75	26074081
567	Phosphorylation	NTKPHQITKKSKKKS CCCHHHCCHHHHHHH	26.33	26074081
570	Phosphorylation	PHQITKKSKKKSFLK HHHCCHHHHHHHHHH	51.79	26074081
572	Ubiquitination	QITKKSKKKSFLKED HCCHHHHHHHHHHHH	61.82	22817900
573	Ubiquitination	ITKKSKKKSFLKEDQ CCHHHHHHHHHHHHH	50.61	22817900
574	Phosphorylation	TKKSKKKSFLKEDQN CHHHHHHHHHHHHHH	44.70	26074081
577	Ubiquitination	SKKKSFLKEDQNKAQ HHHHHHHHHHHHHHH	58.18	22817900
582	Ubiquitination	FLKEDQNKAQQNDDL HHHHHHHHHHHCCCH	41.77	22817900
647	Phosphorylation	CRGEGKISKDLSIAV HCCCCCCCHHHHHHH	24.49	-
648	Acetylation	RGEGKISKDLSIAVQ CCCCCCCHHHHHHHH	67.19	30588097
651	Phosphorylation	GKISKDLSIAVQMMK CCCCHHHHHHHHHHH	20.73	-
658	Acetylation	SIAVQMMKRIHSLLE HHHHHHHHHHHHHHH	42.74	25953088
704	Ubiquitination	PTLIGDDKNKKKYSI CCCCCCCCCCCEEEE	75.34	22817900
706	Ubiquitination	LIGDDKNKKKYSIDI CCCCCCCCCEEEEEE	57.28	22817900
707	Ubiquitination	IGDDKNKKKYSIDIG CCCCCCCCEEEEEEC	67.35	22817900
708	Ubiquitination	GDDKNKKKYSIDIGP CCCCCCCEEEEEECC	45.93	22817900
709	Phosphorylation	DDKNKKKYSIDIGPA CCCCCCEEEEEECCH	21.53	-
757	Ubiquitination	ELLDVVDKNESAVIV HHHHHHCCCCCEEEE	51.51	-
771	Ubiquitination	VAPTSSGKTYASYYC EEECCCCCCHHHHHH	40.07	-
772	Phosphorylation	APTSSGKTYASYYCM EECCCCCCHHHHHHH	28.04	23401153
773	Phosphorylation	PTSSGKTYASYYCME ECCCCCCHHHHHHHH	9.31	23401153
775	Phosphorylation	SSGKTYASYYCMEKV CCCCCHHHHHHHHHH	13.25	23401153
776	Phosphorylation	SGKTYASYYCMEKVL CCCCHHHHHHHHHHH	7.78	23401153
777	Phosphorylation	GKTYASYYCMEKVLR CCCHHHHHHHHHHHH	5.26	23401153
814	Ubiquitination	TVENRFTKTLPAGRT HHHHCCCCCCCCCCC	45.40	27667366
887	Ubiquitination	AKFWELLLVIIRCPF HHHHHHHHHHHHCCH	3.98	27667366
919	Ubiquitination	QSVKQYWKQADKIME HHHHHHHHHHHHHHH	30.58	27667366
1041	Ubiquitination	EFILFKNKIVIKKLD HEEEECCEEEEEECC	38.65	-
1052	Phosphorylation	KKLDARKYEENLKAE EECCHHHHHHHHHHH	23.95	29116813
1061	Phosphorylation	ENLKAELTNWIKNGQ HHHHHHHHHHHHHCC	21.73	29116813
1080	Phosphorylation	KRVLKNLSPDSLSSS HHHHHHCCCCCCCCC	35.73	25332170
1086	Phosphorylation	LSPDSLSSSKDMVKM CCCCCCCCCHHHHHH	46.85	25332170
1166	Acetylation	KTQKRITKKNPKKAE HHHHHHHHCCHHHHH	48.45	91251
1170	Acetylation	RITKKNPKKAEKLER HHHHCCHHHHHHHHH	74.20	91253
1171	Acetylation	ITKKNPKKAEKLERK HHHCCHHHHHHHHHH	64.14	91255
1174	Acetylation	KNPKKAEKLERKKVY CCHHHHHHHHHHHHH	61.58	91257
1178	Acetylation	KAEKLERKKVYRAEY HHHHHHHHHHHHHHH	36.90	91259
1185	Phosphorylation	KKVYRAEYINFLENL HHHHHHHHHHHHHHC	10.53	27642862
1203	Phosphorylation	EISEDCTYADVKALH EECCCCCHHHHHHHH	13.72	27642862
1207	Ubiquitination	DCTYADVKALHTEIT CCCHHHHHHHHHHHH	45.86	29967540
1208	Ubiquitination	CTYADVKALHTEITR CCHHHHHHHHHHHHC	12.39	29967540
1219	Phosphorylation	EITRNKDSTLERVLP HHHCCCCCHHHHHHC	36.18	28122231
1220	Phosphorylation	ITRNKDSTLERVLPR HHCCCCCHHHHHHCC	42.65	28122231
1337	Phosphorylation	KIKRLLASSVPELRG HHHHHHHCCCCHHCC	31.66	-
1338	Phosphorylation	IKRLLASSVPELRGQ HHHHHHCCCCHHCCC	35.76	-
1349	Phosphorylation	LRGQFPLSITLVLRL HCCCCCHHHHHHHHH	17.48	-
1351	Phosphorylation	GQFPLSITLVLRLML CCCCHHHHHHHHHHH	13.87	-
1361	Phosphorylation	LRLMLLASKGDDPED HHHHHHHHCCCCHHH	36.82	-
1370	Acetylation	GDDPEDAKAKVLSVL CCCHHHHHHHHHHHH	62.15	11731791
1372	Acetylation	DPEDAKAKVLSVLKH CHHHHHHHHHHHHHH	42.90	11731799
1383	Phosphorylation	VLKHSLLSFKRRRAM HHHHHHHHHHHHHHH	33.73	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX6L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX6L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX6L_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DDX6L_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.