dbPTM

SYUA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYUA_MOUSE
UniProt AC	O55042
Protein Name	Alpha-synuclein
Gene Name	Snca
Organism	Mus musculus (Mouse).
Sequence Length	140
Subcellular Localization	Cytoplasm, cytosol . Membrane . Nucleus . Cell junction, synapse . Secreted .
Protein Description	May be involved in the regulation of dopamine release and transport..
Protein Sequence	MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDPGSEAYEMPSEEGYQDYEPEA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDVFMKGL -------CCCCHHHH	10.01	-
6	Ubiquitination	--MDVFMKGLSKAKE --CCCCHHHHHHHHH	45.28	22790023
6	Acetylation	--MDVFMKGLSKAKE --CCCCHHHHHHHHH	45.28	72666597
10	Acetylation	VFMKGLSKAKEGVVA CCHHHHHHHHHHHHH	69.40	126682805
12	Methylation	MKGLSKAKEGVVAAA HHHHHHHHHHHHHHH	59.75	-
21	Ubiquitination	GVVAAAEKTKQGVAE HHHHHHHHHHHHHHH	57.19	27667366
32	Ubiquitination	GVAEAAGKTKEGVLY HHHHHCCCCCCEEEE	52.26	27667366
34	Ubiquitination	AEAAGKTKEGVLYVG HHHCCCCCCEEEEEC	56.83	27667366
39	Nitration	KTKEGVLYVGSKTKE CCCCEEEEECCCCCC	10.60	-
39	Phosphorylation	KTKEGVLYVGSKTKE CCCCEEEEECCCCCC	10.60	-
42	Phosphorylation	EGVLYVGSKTKEGVV CEEEEECCCCCCCEE	27.40	25521595
43	Ubiquitination	GVLYVGSKTKEGVVH EEEEECCCCCCCEEE	58.65	27667366
45	Methylation	LYVGSKTKEGVVHGV EEECCCCCCCEEEEE	57.09	-
53	O-linked_Glycosylation	EGVVHGVTTVAEKTK CCEEEEEEECCHHHH	21.83	30059200
54	O-linked_Glycosylation	GVVHGVTTVAEKTKE CEEEEEEECCHHHHH	18.47	30059200
59	O-linked_Glycosylation	VTTVAEKTKEQVTNV EEECCHHHHHHHHCC	31.17	55413973
64	O-linked_Glycosylation	EKTKEQVTNVGGAVV HHHHHHHHCCCCEEE	24.71	30059200
72	O-linked_Glycosylation	NVGGAVVTGVTAVAQ CCCCEEEECCEEEEE	21.24	30059200
81	Phosphorylation	VTAVAQKTVEGAGNI CEEEEEHHHCCCCHH	16.23	22324799
92	Phosphorylation	AGNIAAATGFVKKDQ CCHHHHHCCCEEHHH	26.82	29899451
96	Ubiquitination	AAATGFVKKDQMGKG HHHCCCEEHHHCCCC	48.66	22790023
122	Phosphorylation	DMPVDPGSEAYEMPS CCCCCCCCCCCCCCC	25.17	29899451
125	Nitration	VDPGSEAYEMPSEEG CCCCCCCCCCCCCCC	14.54	-
125	Phosphorylation	VDPGSEAYEMPSEEG CCCCCCCCCCCCCCC	14.54	-
129	Phosphorylation	SEAYEMPSEEGYQDY CCCCCCCCCCCCCCC	47.14	16141072
133	Nitration	EMPSEEGYQDYEPEA CCCCCCCCCCCCCCC	11.07	-
133	Phosphorylation	EMPSEEGYQDYEPEA CCCCCCCCCCCCCCC	11.07	29899451
136	Nitration	SEEGYQDYEPEA--- CCCCCCCCCCCC---	20.18	-
136	Phosphorylation	SEEGYQDYEPEA--- CCCCCCCCCCCC---	20.18	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
125	Y	Phosphorylation	Kinase	FYN	P39688	Uniprot
129	S	Phosphorylation	Kinase	PLK2	P53351	Uniprot
129	S	Phosphorylation	Kinase	PLK3	Q9H4B4	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	Ube3a	O08759	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1	M	Acetylation		-
Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYUA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBA3_MOUSE	Tuba3a	physical	11687285
STX1A_MOUSE	Stx1a	physical	21151134
SNP25_MOUSE	Snap25	physical	21151134
VAMP2_MOUSE	Vamp2	physical	21151134
KCJ11_MOUSE	Kcnj11	physical	20858756
STX1A_MOUSE	Stx1a	physical	20798282
VAMP2_MOUSE	Vamp2	physical	20798282
SNP25_MOUSE	Snap25	physical	20798282
A4_MOUSE	App	physical	18769546
SYPH_MOUSE	Syp	physical	18808659

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYUA_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine129 in central nervous system."; Inglis K.J., Chereau D., Brigham E.F., Chiou S.S., Schobel S.,Frigon N.L., Yu M., Caccavello R.J., Nelson S., Motter R., Wright S.,Chian D., Santiago P., Soriano F., Ramos C., Powell K.,Goldstein J.M., Babcock M., Yednock T., Bard F., Basi G.S., Sham H.,Chilcote T.J., McConlogue L., Griswold-Prenner I., Anderson J.P.; J. Biol. Chem. 284:2598-2602(2009). Cited for: PHOSPHORYLATION AT SER-129.	19004816 [Abstract]

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