| UniProt ID | TBA3_MOUSE | |
|---|---|---|
| UniProt AC | P05214 | |
| Protein Name | Tubulin alpha-3 chain | |
| Gene Name | Tuba3a | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 450 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. | |
| Protein Description | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.. | |
| Protein Sequence | MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVEAEAEEGEEY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MRECISIHVGQAG --CCCEEEEEECCHH | 20.50 | 15345747 | |
| 40 | Acetylation | DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC | 46.51 | 8275617 | |
| 40 | Ubiquitination | DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC | 46.51 | - | |
| 41 | Phosphorylation | GQMPSDKTIGGGDDS CCCCCCCCCCCCCCC | 29.82 | 25521595 | |
| 48 | Phosphorylation | TIGGGDDSFNTFFSE CCCCCCCCHHHCCCC | 25.74 | 25521595 | |
| 51 | Phosphorylation | GGDDSFNTFFSETGA CCCCCHHHCCCCCCC | 24.85 | 24925903 | |
| 54 | Phosphorylation | DSFNTFFSETGAGKH CCHHHCCCCCCCCCC | 30.02 | 25521595 | |
| 56 | Phosphorylation | FNTFFSETGAGKHVP HHHCCCCCCCCCCCC | 31.00 | 25159016 | |
| 60 | Acetylation | FSETGAGKHVPRAVF CCCCCCCCCCCEEEE | 40.68 | 19850279 | |
| 60 | Ubiquitination | FSETGAGKHVPRAVF CCCCCCCCCCCEEEE | 40.68 | - | |
| 82 | Phosphorylation | VDEVRTGTYRQLFHP EECCCCCCCHHCCCH | 18.21 | - | |
| 83 | Nitration | DEVRTGTYRQLFHPE ECCCCCCCHHCCCHH | 9.56 | - | |
| 83 | Phosphorylation | DEVRTGTYRQLFHPE ECCCCCCCHHCCCHH | 9.56 | - | |
| 83 | Nitrated tyrosine | DEVRTGTYRQLFHPE ECCCCCCCHHCCCHH | 9.56 | - | |
| 94 | Phosphorylation | FHPEQLITGKEDAAN CCHHHHCCCCHHHHH | 51.28 | 27600695 | |
| 96 | Ubiquitination | PEQLITGKEDAANNY HHHHCCCCHHHHHHC | 43.71 | - | |
| 103 | Phosphorylation | KEDAANNYARGHYTI CHHHHHHCCCCCCCC | 9.48 | 22817900 | |
| 108 | Phosphorylation | NNYARGHYTIGKEIV HHCCCCCCCCCHHHH | 11.68 | 25195567 | |
| 109 | Phosphorylation | NYARGHYTIGKEIVD HCCCCCCCCCHHHHH | 19.99 | 19854140 | |
| 158 | Phosphorylation | SLLMERLSVDYGKKS HHHHHHHCCCCCCCC | 21.11 | 27180971 | |
| 161 | Phosphorylation | MERLSVDYGKKSKLE HHHHCCCCCCCCCCE | 28.79 | 29472430 | |
| 163 | Acetylation | RLSVDYGKKSKLEFA HHCCCCCCCCCCEEE | 47.87 | 7609119 | |
| 163 | Ubiquitination | RLSVDYGKKSKLEFA HHCCCCCCCCCCEEE | 47.87 | - | |
| 164 | Ubiquitination | LSVDYGKKSKLEFAI HCCCCCCCCCCEEEE | 48.75 | - | |
| 165 | Phosphorylation | SVDYGKKSKLEFAIY CCCCCCCCCCEEEEE | 46.06 | - | |
| 210 | Phosphorylation | MVDNEAIYDICRRNL EECHHHHHHHHHCCC | 13.30 | 22817900 | |
| 223 | Phosphorylation | NLDIERPTYTNLNRL CCCCCCCCCCCHHHH | 49.55 | 20415495 | |
| 224 | Phosphorylation | LDIERPTYTNLNRLI CCCCCCCCCCHHHHH | 9.05 | 20415495 | |
| 225 | Phosphorylation | DIERPTYTNLNRLIG CCCCCCCCCHHHHHH | 35.39 | 20415495 | |
| 237 | Phosphorylation | LIGQIVSSITASLRF HHHHHHHHHHHHCCC | 17.05 | - | |
| 271 | Phosphorylation | RIHFPLATYAPVISA CCCCCCCCCCCCCCH | 28.09 | 25159016 | |
| 272 | Phosphorylation | IHFPLATYAPVISAE CCCCCCCCCCCCCHH | 11.87 | 25159016 | |
| 277 | Phosphorylation | ATYAPVISAEKAYHE CCCCCCCCHHHHHHH | 30.52 | 25159016 | |
| 277 | O-linked_Glycosylation | ATYAPVISAEKAYHE CCCCCCCCHHHHHHH | 30.52 | 30813383 | |
| 280 | Ubiquitination | APVISAEKAYHEQLS CCCCCHHHHHHHHCC | 54.70 | - | |
| 282 | Phosphorylation | VISAEKAYHEQLSVA CCCHHHHHHHHCCHH | 19.56 | 26745281 | |
| 287 | Phosphorylation | KAYHEQLSVAEITNA HHHHHHCCHHHHHHH | 20.98 | 25521595 | |
| 292 | Phosphorylation | QLSVAEITNACFEPA HCCHHHHHHHHCCCH | 14.31 | 23984901 | |
| 304 | Ubiquitination | EPANQMVKCDPRHGK CCHHHCCCCCCCCCC | 27.81 | - | |
| 326 | Ubiquitination | YRGDVVPKDVNAAIA CCCCCCCCCCCHHHH | 63.80 | - | |
| 334 | Phosphorylation | DVNAAIATIKTKRTI CCCHHHHHCCCCCEE | 19.52 | 26824392 | |
| 336 | Ubiquitination | NAAIATIKTKRTIQF CHHHHHCCCCCEEEE | 43.57 | - | |
| 337 | Phosphorylation | AAIATIKTKRTIQFV HHHHHCCCCCEEEEE | 23.16 | 27600695 | |
| 338 | Ubiquitination | AIATIKTKRTIQFVD HHHHCCCCCEEEEEE | 42.41 | - | |
| 340 | Phosphorylation | ATIKTKRTIQFVDWC HHCCCCCEEEEEEEC | 22.23 | 22817900 | |
| 352 | Ubiquitination | DWCPTGFKVGINYQP EECCCCEEEEEECCC | 40.68 | - | |
| 352 | Acetylation | DWCPTGFKVGINYQP EECCCCEEEEEECCC | 40.68 | 7969707 | |
| 357 | Phosphorylation | GFKVGINYQPPTVVP CEEEEEECCCCEECC | 22.07 | 25521595 | |
| 361 | Phosphorylation | GINYQPPTVVPGGDL EEECCCCEECCCCCH | 40.60 | 25159016 | |
| 370 | Ubiquitination | VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH | 46.31 | - | |
| 379 | Phosphorylation | QRAVCMLSNTTAIAE HHHHHHHCCHHHHHH | 12.78 | 22817900 | |
| 381 | Phosphorylation | AVCMLSNTTAIAEAW HHHHHCCHHHHHHHH | 17.77 | 23984901 | |
| 382 | Phosphorylation | VCMLSNTTAIAEAWA HHHHCCHHHHHHHHH | 21.95 | 23984901 | |
| 394 | Ubiquitination | AWARLDHKFDLMYAK HHHHCCCCCCHHHEE | 39.99 | - | |
| 399 | Phosphorylation | DHKFDLMYAKRAFVH CCCCCHHHEEEHHHH | 19.10 | 26745281 | |
| 401 | Ubiquitination | KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH | 27.11 | - | |
| 401 | Acetylation | KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH | 27.11 | 7675323 | |
| 408 | Phosphorylation | KRAFVHWYVGEGMEE EEHHHHHHCCCCCCC | 5.45 | 25777480 | |
| 432 | Phosphorylation | LAALEKDYEEVGVDS HHHHHHHHHHHCCCC | 25.67 | - | |
| 439 | Phosphorylation | YEEVGVDSVEAEAEE HHHHCCCCCCCHHHC | 21.32 | 23140645 | |
| 450 | Nitration | EAEEGEEY------- HHHCCCCC------- | 21.39 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TBA3_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 40 | K | Acetylation |
| - |
| 40 | K | Methylation |
| - |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TBA3_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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