RBM33_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBM33_HUMAN
• UniProt AC: Q96EV2
• Protein Name: RNA-binding protein 33
• Gene Name: RBM33
• Organism: Homo sapiens (Human).
• Sequence Length: 1170
• Protein Sequence: MAAALGASGGAGAGDDDFDQFDKPGAERSWRRRAADEDWDSELEDDLLGEDLLSGKKNQSDLSDEELNDDLLQSDNEDEENFSSQGVTISLNATSGMVTSFELSDNTNDQSGEQESEYEQEQGEDELVYHKSDGSELYTQEYPEEGQYEGHEAELTEDQIEYVEEPEEEQLYTDEVLDIEINEPLDEFTGGMETLELQKDIKEESDEEEEDDEESGRLRFKTERKEGTIIRLSDVTRERRNIPETLELSAEAKAALLEFEERERQHKQGRYSSRRGGRRGGPLMCRGVGDQRRESTERGRMKDHRPALLPTQPPVVPQAPPPPPPPPQQQPIRSLFQPQPLQPLLPVQHPHHPSPPQGMHMPPQLETPRMMMTPPPVTPQQPKNIHINPHFKGTVVTPVQVPLLPVPSQPRPAVGPQRFPGPPEFPQHTPGPVPNSFSQPPRLPLQDQWRAPPPPQDRDPFFLGVSGEPRFPSHLFLEQRSPPPPPPPPTLLNSSHPVPTQSPLPFTQPGPAFNQQGQQPVFPRERPVRPALQPPGPVGILHFSQPGSATTRPFIPPRQPFLPGPGQPFLPTHTQPNLQGPLHPPLPPPHQPQPQQPQQQPPPQHQPPHQPPHQPPPQHQPPPQHPPQHPPQHQHHHHHHHLSVPPPPLMPMSQPQFRPHVQTAQPQASSSRMQCPQRQGLRHNTTSQNVSKRPMQQMQPTAPRNSNLRELPIAPSHVIEMSSSRCSATPSAQVKPIVSASPPSRAVAGSRSSQGKTEVKVKPASPVAQPKEEAKTETEFPDEDEETRLYRLKIEEQKRLREEILKQKELRRQQQAGARKKELLERLAQQQQQLYAPPPPAEQEEQALSPSPTNGNPLLPFPGAQVRQNVKNRLLVKNQDVSISNVQPKTSNFVPSSANMQYQGQQMKALKHLRQTRTVPQSQTQPLHKVLPIKPADVEEPAVPQTPRVASIQGRPQDTKPGVKRTVTHRTNSGGGDGPHISSKVRVIKLSGGGGESDGFFHPEGQPQRLPQPPEVGPQPARKVTLTRGGLQQPPHLPAGPHAHSPVPPGIKSIQGIHPAKKAIMHGRGRGVAGPMGRGRLMPNKQNLRVVECKPQPCVVSVEGLSSSTTDAQLKSLLMSVGPIQSLQMLPQQRKAIAKFKEPAHALAFQQKFHRHMIDLSHINVALIVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAALGASG ------CCCCCCCCC	16.85	22814378
8	Phosphorylation	MAAALGASGGAGAGD CCCCCCCCCCCCCCC	35.64	29743597
23	Acetylation	DDFDQFDKPGAERSW CCHHHCCCCCHHHHH	46.79	25953088
29	Phosphorylation	DKPGAERSWRRRAAD CCCCHHHHHHHHHCC	19.21	27251275
41	Phosphorylation	AADEDWDSELEDDLL HCCCCCCHHHHHCCC	39.57	19664994
54	Phosphorylation	LLGEDLLSGKKNQSD CCCHHHHCCCCCHHH	56.73	23403867
56	Acetylation	GEDLLSGKKNQSDLS CHHHHCCCCCHHHCC	45.21	26051181
148	Phosphorylation	EYPEEGQYEGHEAEL ECCCCCCCCCCCEEC	34.43	-
171	Phosphorylation	EEPEEEQLYTDEVLD CCCHHHHCCCCCEEE	5.86	15302935
185	Phosphorylation	DIEINEPLDEFTGGM EEEECCCHHHHCCCH	8.87	15302935
202	Sumoylation	LELQKDIKEESDEEE HHHHHHHHHHCCCCC	66.61	-
205	Phosphorylation	QKDIKEESDEEEEDD HHHHHHHCCCCCCCC	51.95	22167270
215	Phosphorylation	EEEDDEESGRLRFKT CCCCCHHHCCEEEEE	27.45	22167270
224	Dimethylation	RLRFKTERKEGTIIR CEEEEEEECCCEEEE	47.78	-
224	Methylation	RLRFKTERKEGTIIR CEEEEEEECCCEEEE	47.78	24379947
228	Phosphorylation	KTERKEGTIIRLSDV EEEECCCEEEEHHHH	17.83	20068231
231	Dimethylation	RKEGTIIRLSDVTRE ECCCEEEEHHHHCHH	25.04	-
231	Methylation	RKEGTIIRLSDVTRE ECCCEEEEHHHHCHH	25.04	24379957
233	Phosphorylation	EGTIIRLSDVTRERR CCEEEEHHHHCHHHC	21.86	25159151
236	Phosphorylation	IIRLSDVTRERRNIP EEEHHHHCHHHCCCC	31.63	20068231
237	Dimethylation	IRLSDVTRERRNIPE EEHHHHCHHHCCCCC	34.96	-
237	Methylation	IRLSDVTRERRNIPE EEHHHHCHHHCCCCC	34.96	24379967
245	Phosphorylation	ERRNIPETLELSAEA HHCCCCCHHHHCHHH	21.85	27251275
245 (in isoform 2)	Phosphorylation	-	21.85	19845377
249	Phosphorylation	IPETLELSAEAKAAL CCCHHHHCHHHHHHH	18.06	29396449
253	Ubiquitination	LELSAEAKAALLEFE HHHCHHHHHHHHHHH	26.20	29967540
256 (in isoform 2)	Phosphorylation	-	5.86	19845377
258 (in isoform 2)	Phosphorylation	-	52.44	19845377
261 (in isoform 2)	Phosphorylation	-	66.23	19845377
271	Phosphorylation	RQHKQGRYSSRRGGR HHHHCCCCCCCCCCC	20.16	26074081
272	Phosphorylation	QHKQGRYSSRRGGRR HHHCCCCCCCCCCCC	18.93	26074081
273	Phosphorylation	HKQGRYSSRRGGRRG HHCCCCCCCCCCCCC	19.64	26074081
279	Methylation	SSRRGGRRGGPLMCR CCCCCCCCCCCCCCC	58.66	16289391
286	Methylation	RGGPLMCRGVGDQRR CCCCCCCCCCCHHCH	28.94	30988979
295	Phosphorylation	VGDQRRESTERGRMK CCHHCHHHCCCCCCC	33.48	26074081
296	Phosphorylation	GDQRRESTERGRMKD CHHCHHHCCCCCCCC	25.58	26074081
302	Methylation	STERGRMKDHRPALL HCCCCCCCCCCCCCC	49.36	24129315
311	Phosphorylation	HRPALLPTQPPVVPQ CCCCCCCCCCCCCCC	54.39	-
373	Phosphorylation	ETPRMMMTPPPVTPQ CCCCCCCCCCCCCCC	18.10	28985074
378	Phosphorylation	MMTPPPVTPQQPKNI CCCCCCCCCCCCCCC	22.58	23186163
394	Phosphorylation	INPHFKGTVVTPVQV CCCCCCCCEEECCCC	16.64	28122231
397	Phosphorylation	HFKGTVVTPVQVPLL CCCCCEEECCCCCCC	17.26	28348404
442	Dimethylation	NSFSQPPRLPLQDQW CCCCCCCCCCCCCCC	56.47	-
442	Methylation	NSFSQPPRLPLQDQW CCCCCCCCCCCCCCC	56.47	52717395
450	Dimethylation	LPLQDQWRAPPPPQD CCCCCCCCCCCCCCC	31.42	-
450	Methylation	LPLQDQWRAPPPPQD CCCCCCCCCCCCCCC	31.42	54549455
470	Asymmetric dimethylarginine	LGVSGEPRFPSHLFL EECCCCCCCCCCCCC	52.37	-
470	Methylation	LGVSGEPRFPSHLFL EECCCCCCCCCCCCC	52.37	24129315
481	Phosphorylation	HLFLEQRSPPPPPPP CCCCCCCCCCCCCCC	41.26	26074081
490	Phosphorylation	PPPPPPPTLLNSSHP CCCCCCCCCCCCCCC	50.04	26434776
494	Phosphorylation	PPPTLLNSSHPVPTQ CCCCCCCCCCCCCCC	29.96	26434776
495	Phosphorylation	PPTLLNSSHPVPTQS CCCCCCCCCCCCCCC	30.64	26434776
500	Phosphorylation	NSSHPVPTQSPLPFT CCCCCCCCCCCCCCC	41.74	26074081
502	Phosphorylation	SHPVPTQSPLPFTQP CCCCCCCCCCCCCCC	30.77	26074081
507	Phosphorylation	TQSPLPFTQPGPAFN CCCCCCCCCCCCCCC	31.73	25002506
524	Methylation	GQQPVFPRERPVRPA CCCCCCCCCCCCCCC	40.88	81452797
658	Dimethylation	PMSQPQFRPHVQTAQ CCCCCCCCCCCCCCC	18.37	-
658	Methylation	PMSQPQFRPHVQTAQ CCCCCCCCCCCCCCC	18.37	54561675
672	Dimethylation	QPQASSSRMQCPQRQ CCCCCCCCCCCCHHH	22.57	-
672	Methylation	QPQASSSRMQCPQRQ CCCCCCCCCCCCHHH	22.57	54561667
678	Dimethylation	SRMQCPQRQGLRHNT CCCCCCHHHCCCCCC	20.06	-
678	Methylation	SRMQCPQRQGLRHNT CCCCCCHHHCCCCCC	20.06	54561691
682	Dimethylation	CPQRQGLRHNTTSQN CCHHHCCCCCCCCCC	28.03	-
682	Methylation	CPQRQGLRHNTTSQN CCHHHCCCCCCCCCC	28.03	54558599
692	Acetylation	TTSQNVSKRPMQQMQ CCCCCCCCCCHHHCC	57.13	24469647
693	Methylation	TSQNVSKRPMQQMQP CCCCCCCCCHHHCCC	25.15	115490743
706	Phosphorylation	QPTAPRNSNLRELPI CCCCCCCCCCCCCCC	38.22	28555341
722	Phosphorylation	PSHVIEMSSSRCSAT HHHEEEECCCCCCCC	16.63	28555341
724	O-linked_Glycosylation	HVIEMSSSRCSATPS HEEEECCCCCCCCCC	29.96	30379171
724	Phosphorylation	HVIEMSSSRCSATPS HEEEECCCCCCCCCC	29.96	-
727	Phosphorylation	EMSSSRCSATPSAQV EECCCCCCCCCCCCC	33.78	23403867
729	Phosphorylation	SSSRCSATPSAQVKP CCCCCCCCCCCCCCC	11.07	23663014
731	Phosphorylation	SRCSATPSAQVKPIV CCCCCCCCCCCCCCE	27.29	23927012
735	Acetylation	ATPSAQVKPIVSASP CCCCCCCCCCEECCC	19.56	25953088
739	O-linked_Glycosylation	AQVKPIVSASPPSRA CCCCCCEECCCCCCC	24.61	30379171
739	Phosphorylation	AQVKPIVSASPPSRA CCCCCCEECCCCCCC	24.61	23401153
741	Phosphorylation	VKPIVSASPPSRAVA CCCCEECCCCCCCCC	29.82	19664994
744	Phosphorylation	IVSASPPSRAVAGSR CEECCCCCCCCCCCC	35.93	30266825
750	Phosphorylation	PSRAVAGSRSSQGKT CCCCCCCCCCCCCCC	21.17	26074081
752	Phosphorylation	RAVAGSRSSQGKTEV CCCCCCCCCCCCCEE	28.80	26074081
753	Phosphorylation	AVAGSRSSQGKTEVK CCCCCCCCCCCCEEE	41.67	26074081
756	Acetylation	GSRSSQGKTEVKVKP CCCCCCCCCEEEEEC	33.60	26051181
757	Phosphorylation	SRSSQGKTEVKVKPA CCCCCCCCEEEEECC	53.48	23312004
765	Phosphorylation	EVKVKPASPVAQPKE EEEEECCCCCCCCHH	28.56	29255136
776	Phosphorylation	QPKEEAKTETEFPDE CCHHHHCCCCCCCCC	56.01	23403867
778	Phosphorylation	KEEAKTETEFPDEDE HHHHCCCCCCCCCCH	48.43	28270605
793	Sumoylation	ETRLYRLKIEEQKRL HHHHHHHHHHHHHHH	38.79	-
798	Ubiquitination	RLKIEEQKRLREEIL HHHHHHHHHHHHHHH	57.59	24816145
808	Ubiquitination	REEILKQKELRRQQQ HHHHHHHHHHHHHHH	58.07	24816145
835	Phosphorylation	AQQQQQLYAPPPPAE HHHHHHHHCCCCCHH	16.84	30108239
838	Ubiquitination	QQQLYAPPPPAEQEE HHHHHCCCCCHHHHH	39.06	24816145
848	Ubiquitination	AEQEEQALSPSPTNG HHHHHHHCCCCCCCC	8.48	24816145
849	Phosphorylation	EQEEQALSPSPTNGN HHHHHHCCCCCCCCC	26.75	25022875
851	Phosphorylation	EEQALSPSPTNGNPL HHHHCCCCCCCCCCC	40.77	30108239
853	Phosphorylation	QALSPSPTNGNPLLP HHCCCCCCCCCCCCC	61.16	30108239
877	Sumoylation	VKNRLLVKNQDVSIS HHHCEEECCCCEECC	49.19	-
877	Sumoylation	VKNRLLVKNQDVSIS HHHCEEECCCCEECC	49.19	-
882	O-linked_Glycosylation	LVKNQDVSISNVQPK EECCCCEECCCCCCC	28.70	30379171
882	Phosphorylation	LVKNQDVSISNVQPK EECCCCEECCCCCCC	28.70	28176443
884	Phosphorylation	KNQDVSISNVQPKTS CCCCEECCCCCCCCC	24.36	28176443
889	Methylation	SISNVQPKTSNFVPS ECCCCCCCCCCCCCC	47.71	24129315
934	Sumoylation	LHKVLPIKPADVEEP HHCCCCCCCCCCCCC	32.01	-
934	Acetylation	LHKVLPIKPADVEEP HHCCCCCCCCCCCCC	32.01	26051181
934	Sumoylation	LHKVLPIKPADVEEP HHCCCCCCCCCCCCC	32.01	-
934	Ubiquitination	LHKVLPIKPADVEEP HHCCCCCCCCCCCCC	32.01	29967540
946	Phosphorylation	EEPAVPQTPRVASIQ CCCCCCCCCCEEEEC	13.64	29255136
951	Phosphorylation	PQTPRVASIQGRPQD CCCCCEEEECCCCCC	16.76	23917254
960	Acetylation	QGRPQDTKPGVKRTV CCCCCCCCCCCEEEE	48.33	23749302
960	Sumoylation	QGRPQDTKPGVKRTV CCCCCCCCCCCEEEE	48.33	28112733
960	Ubiquitination	QGRPQDTKPGVKRTV CCCCCCCCCCCEEEE	48.33	24816145
964	Methylation	QDTKPGVKRTVTHRT CCCCCCCEEEEEECC	48.55	116253411
966	Phosphorylation	TKPGVKRTVTHRTNS CCCCCEEEEEECCCC	24.84	29514088
968	Phosphorylation	PGVKRTVTHRTNSGG CCCEEEEEECCCCCC	12.67	29514088
970	Ubiquitination	VKRTVTHRTNSGGGD CEEEEEECCCCCCCC	26.66	24816145
971	Phosphorylation	KRTVTHRTNSGGGDG EEEEEECCCCCCCCC	26.57	21955146
973	Phosphorylation	TVTHRTNSGGGDGPH EEEECCCCCCCCCCC	37.90	25159151
982	Phosphorylation	GGDGPHISSKVRVIK CCCCCCCCCEEEEEE	22.52	23403867
983	Phosphorylation	GDGPHISSKVRVIKL CCCCCCCCEEEEEEE	34.27	23403867
984	Acetylation	DGPHISSKVRVIKLS CCCCCCCEEEEEEEC	27.54	25953088
991	Phosphorylation	KVRVIKLSGGGGESD EEEEEEECCCCCCCC	30.32	25159151
1000	Ubiquitination	GGGESDGFFHPEGQP CCCCCCCCCCCCCCC	6.45	24816145
1010	Ubiquitination	PEGQPQRLPQPPEVG CCCCCCCCCCCCCCC	3.78	24816145
1028	Asymmetric dimethylarginine	ARKVTLTRGGLQQPP CCEEEEECCCCCCCC	40.05	-
1028	Methylation	ARKVTLTRGGLQQPP CCEEEEECCCCCCCC	40.05	24129315
1045	Phosphorylation	PAGPHAHSPVPPGIK CCCCCCCCCCCCCCC	28.51	29255136
1061	Acetylation	IQGIHPAKKAIMHGR HCCCCHHHHHHHCCC	47.38	25953088
1070	Dimethylation	AIMHGRGRGVAGPMG HHHCCCCCCCCCCCC	34.74	-
1070	Methylation	AIMHGRGRGVAGPMG HHHCCCCCCCCCCCC	34.74	26494771
1078	Dimethylation	GVAGPMGRGRLMPNK CCCCCCCCCCCCCCC	22.32	-
1078	Methylation	GVAGPMGRGRLMPNK CCCCCCCCCCCCCCC	22.32	54558623
1085	Acetylation	RGRLMPNKQNLRVVE CCCCCCCCCCEEEEE	34.39	19821601
1085	Ubiquitination	RGRLMPNKQNLRVVE CCCCCCCCCCEEEEE	34.39	29967540
1094	Acetylation	NLRVVECKPQPCVVS CEEEEECCCCCEEEE	32.93	25953088
1106	Phosphorylation	VVSVEGLSSSTTDAQ EEEEECCCCCCCHHH	32.85	27251275
1107	Phosphorylation	VSVEGLSSSTTDAQL EEEECCCCCCCHHHH	36.42	27251275
1108	Phosphorylation	SVEGLSSSTTDAQLK EEECCCCCCCHHHHH	31.76	27251275
1109	Phosphorylation	VEGLSSSTTDAQLKS EECCCCCCCHHHHHH	30.55	27251275
1141	Ubiquitination	RKAIAKFKEPAHALA HHHHHHHCCHHHHHH	63.18	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBM33_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBM33_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBM33_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOM34_HUMAN	TOMM34	physical	22939629
SORC3_HUMAN	SORCS3	physical	22939629
MYO9B_HUMAN	MYO9B	physical	26186194
TRM2A_HUMAN	TRMT2A	physical	26186194
EME1_HUMAN	EME1	physical	26186194
ATF6B_HUMAN	ATF6B	physical	26186194
KPTN_HUMAN	KPTN	physical	26186194
EME1_HUMAN	EME1	physical	28514442
KPTN_HUMAN	KPTN	physical	28514442
MYO9B_HUMAN	MYO9B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41 AND SER-205, AND MASSSPECTROMETRY.
PubMed: 19690332

"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205, AND MASSSPECTROMETRY.
PubMed: 18318008

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-205 AND SER-765,AND MASS SPECTROMETRY.
PubMed: 18669648

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-741 AND SER-765, ANDMASS SPECTROMETRY.
PubMed: 19007248

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-765, AND MASSSPECTROMETRY.
PubMed: 17924679

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41 AND SER-205, AND MASSSPECTROMETRY.
PubMed: 17081983