SORC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SORC3_HUMAN
• UniProt AC: Q9UPU3
• Protein Name: VPS10 domain-containing receptor SorCS3
• Gene Name: SORCS3
• Organism: Homo sapiens (Human).
• Sequence Length: 1222
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Sequence: MEAARTERPAGRPGAPLVRTGLLLLSTWVLAGAEITWDATGGPGRPAAPASRPPALSPLSPRAVASQWPEELASARRAAVLGRRAGPELLPQQGGGRGGEMQVEAGGTSPAGERRGRGIPAPAKLGGARRSRRAQPPITQERGDAWATAPADGSRGSRPLAKGSREEVKAPRAGGSAAEDLRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSTDYGTTYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGATYQKYRLTFYIQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVAGLDKEADLVHMEVRTTDGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVTTSGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMGERKIFKKRKPGAQCALGRDHSGSVVSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLGSDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGGIATIANSESTKEIPNCTSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEAARTERPAGRP --CCCCCCCCCCCCC	31.45	24043423
57	Phosphorylation	ASRPPALSPLSPRAV CCCCCCCCCCCHHHH	26.38	24719451
108	Phosphorylation	MQVEAGGTSPAGERR EEEECCCCCCCCCCC	30.53	28387310
109	Phosphorylation	QVEAGGTSPAGERRG EEECCCCCCCCCCCC	18.94	28387310
148	Phosphorylation	ERGDAWATAPADGSR CCCCCEECCCCCCCC	23.60	-
154	Phosphorylation	ATAPADGSRGSRPLA ECCCCCCCCCCCCCC	33.73	-
176	Phosphorylation	KAPRAGGSAAEDLRL CCCCCCCCHHHHCCC	24.32	24719451
207	N-linked_Glycosylation	MVHWSGHNSSVILIL EEEECCCCCEEEEEE	39.23	UniProtKB CARBOHYD
224	Phosphorylation	LYDFNLGSVTESSLW ECCCCCCCCCHHHHH	29.09	-
228	Phosphorylation	NLGSVTESSLWRSTD CCCCCCHHHHHCCCC	22.74	-
229	Phosphorylation	LGSVTESSLWRSTDY CCCCCHHHHHCCCCC	26.22	24719451
239	Phosphorylation	RSTDYGTTYEKLNDK CCCCCCCCHHHHHHH	25.89	-
251	Phosphorylation	NDKVGLKTVLSYLYV HHHCCHHHHHHHEEE	31.55	19835603
254	Phosphorylation	VGLKTVLSYLYVNPT CCHHHHHHHEEECCC	14.57	26503514
255	Phosphorylation	GLKTVLSYLYVNPTN CHHHHHHHEEECCCC	9.63	19835603
257	Phosphorylation	KTVLSYLYVNPTNKR HHHHHHEEECCCCCC	7.02	29978859
261	Phosphorylation	SYLYVNPTNKRKIML HHEEECCCCCCEEEE	48.44	29978859
270	Phosphorylation	KRKIMLLSDPEMESS CCEEEEECCCCCCCC	47.35	23532336
282	Phosphorylation	ESSILISSDEGATYQ CCCEEEECCCCCCEE	32.46	23532336
321	Phosphorylation	SLDQKLYSSMDFGRR ECCHHHHHCCCHHHH	29.62	-
322	Phosphorylation	LDQKLYSSMDFGRRW CCHHHHHCCCHHHHH	14.60	-
380	Phosphorylation	IQECAETTRSGPFAR HHHHHHHCCCCCCCC	17.84	-
456	N-linked_Glycosylation	AVQEWNQNDTYNLYI EEHHCCCCCCEEEEE	40.14	UniProtKB CARBOHYD
480	Phosphorylation	LAMENIKSSRGLMGN EEHHHHHHCCCCCHH	22.82	18187866
481	Phosphorylation	AMENIKSSRGLMGNI EHHHHHHCCCCCHHH	25.93	18187866
559	Phosphorylation	LQLSENPYSSGRISS EECCCCCCCCCCCCC	27.35	29083192
560	Phosphorylation	QLSENPYSSGRISSK ECCCCCCCCCCCCCC	27.81	29083192
561	Phosphorylation	LSENPYSSGRISSKE CCCCCCCCCCCCCCC	26.67	29083192
782	Phosphorylation	ASPSKDCSLGQSYLN CCCCCCCCCCCHHHH	45.74	27732954
786	Phosphorylation	KDCSLGQSYLNSTGY CCCCCCCHHHHCCCC	29.77	27732954
787	Phosphorylation	DCSLGQSYLNSTGYR CCCCCCHHHHCCCCC	11.30	27732954
789	N-linked_Glycosylation	SLGQSYLNSTGYRRI CCCCHHHHCCCCCCH	29.32	UniProtKB CARBOHYD
790	Phosphorylation	LGQSYLNSTGYRRIV CCCHHHHCCCCCCHH	22.18	27732954
791	Phosphorylation	GQSYLNSTGYRRIVS CCHHHHCCCCCCHHC	36.84	27732954
793	Phosphorylation	SYLNSTGYRRIVSNN HHHHCCCCCCHHCCC	9.23	27732954
800	N-linked_Glycosylation	YRRIVSNNCTDGLRE CCCHHCCCCCCCHHH	23.66	UniProtKB CARBOHYD
809	Phosphorylation	TDGLREKYTAKAQMC CCCHHHHHCHHCCCC	13.74	18083107
840	N-linked_Glycosylation	LVAEQGHNATFIILM EEEECCCCEEEEEEE	47.72	UniProtKB CARBOHYD
932	N-linked_Glycosylation	AIRNKEVNISAVVWP EEECCEECEEEEECH	24.48	UniProtKB CARBOHYD
953	N-linked_Glycosylation	TYFWWFGNSTKPLIT EEEEECCCCCCCEEE	36.71	UniProtKB CARBOHYD
1023	Acetylation	PDIPEWRKDIGNVIK CCCHHHHHHHHHHHH	55.56	30592567
1065	N-linked_Glycosylation	LFILPPKNLTERRKG EEEECCCCCCCCCCC	58.95	UniProtKB CARBOHYD
1170	Phosphorylation	KEQEMIGSVSQSENA HHHHHEEECCCCCCC	13.99	22468782
1183	Phosphorylation	NAPKITLSDFTEPEE CCCCCCCCCCCCHHH	23.25	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SORC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SORC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SORC3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SORC3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.