KCJ11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCJ11_MOUSE
• UniProt AC: Q61743
• Protein Name: ATP-sensitive inward rectifier potassium channel 11
• Gene Name: Kcnj11
• Organism: Mus musculus (Mouse).
• Sequence Length: 390
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity)..
• Protein Sequence: MLSRKGIIPEEYVLTRLAEDPAEPRYRTRERRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMVWWLIAFAHGDLAPGEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNGIFLVAPLIIYHVIDSNSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISPDSLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MLSRKGIIPEEY ---CCCCCCCCCHHH		22790023
12	Phosphorylation	KGIIPEEYVLTRLAE CCCCCHHHHHHHHHC		28464351
180	Phosphorylation	QAHRRAETLIFSKHA HHHHHHHHEEEECCE		10908656
224	Phosphorylation	MQVVRKTTSPEGEVV EEEEECCCCCCCCEE		10698936
341	Phosphorylation	GNTIKVPTPLCTARQ CCEEECCCCCCCHHH		-
372	Phosphorylation	RGPLRKRSVAVAKAK CCCCCCCCEEEECCC		23737553
383	Phosphorylation	AKAKPKFSISPDSLS ECCCCCCCCCCCCCC		28464351
385	Phosphorylation	AKPKFSISPDSLS-- CCCCCCCCCCCCC--		25521595
388	Phosphorylation	KFSISPDSLS----- CCCCCCCCCC-----		20415495
390	Phosphorylation	SISPDSLS------- CCCCCCCC-------		20415495

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
180	T	Phosphorylation	Kinase	KPCA	P20444	PhosphoELM
180	T	Phosphorylation	Kinase	PRKCA	P05696	GPS
224	T	Phosphorylation	Kinase	PRKACA	P05132	GPS
341	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
341	T	Phosphorylation	Kinase	MAPK1	P63085	Uniprot
372	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
385	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
385	S	Phosphorylation	Kinase	MAPK1	P63085	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCJ11_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCJ11_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYUA_MOUSE	Snca	physical	20858756

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.