SYPH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYPH_MOUSE
• UniProt AC: Q62277
• Protein Name: Synaptophysin
• Gene Name: Syp
• Organism: Mus musculus (Mouse).
• Sequence Length: 314
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
• Protein Description: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity..
• Protein Sequence: MLLLADMDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFMRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPASGGGGGYGPQGDYGQQGYGQQGAPTSFSNQM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	N-linked_Glycosylation	RLSVECANKTESALN EEEEEECCCCCCCEE	64.54	-
81	Phosphorylation	PFRLHQVYFDAPSCV CEEEEEEEECCCCCC	6.81	25521595
86	Phosphorylation	QVYFDAPSCVKGGTT EEEECCCCCCCCCEE	33.01	25521595
87	S-nitrosylation	VYFDAPSCVKGGTTK EEECCCCCCCCCEEE	3.40	24895380
89	Ubiquitination	FDAPSCVKGGTTKIF ECCCCCCCCCEEEEE	56.82	-
169	Ubiquitination	AKGLSDVKMATDPEN HCCCCCCEECCCHHH	28.01	27667366
187	Phosphorylation	EMPMCRQTGNTCKEL HCCCCCCCCCCHHHH	17.04	22324799
190	Phosphorylation	MCRQTGNTCKELRDP CCCCCCCCHHHHCCC	26.71	22324799
227	Phosphorylation	LWFVFKETGWAAPFM HHHHHHCCCCCCCCC	38.32	-
269	Phosphorylation	GYGPQDSYGPQGGYQ CCCCCCCCCCCCCCC	40.91	22817900
279	Phosphorylation	QGGYQPDYGQPASGG CCCCCCCCCCCCCCC	25.09	22817900
296	Phosphorylation	GYGPQGDYGQQGYGQ CCCCCCCCCCCCCCC	24.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYPH_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYPH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYPH_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYT1_MOUSE	Syt1	physical	21645620
VAMP2_MOUSE	Vamp2	physical	21645620
PARK7_MOUSE	Park7	physical	21645620
VAMP2_MOUSE	Vamp2	physical	18706977
SNG3_MOUSE	Syngr3	physical	18706977
SCAM1_MOUSE	Scamp1	physical	18706977
STMN3_MOUSE	Stmn3	physical	18706977
RND2_MOUSE	Rnd2	physical	18706977
ARFP2_MOUSE	Arfip2	physical	18706977

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-81, AND MASSSPECTROMETRY.
PubMed: 18034455