STMN3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STMN3_MOUSE
• UniProt AC: O70166
• Protein Name: Stathmin-3
• Gene Name: Stmn3
• Organism: Mus musculus (Mouse).
• Sequence Length: 180
• Subcellular Localization: Golgi apparatus. Cell projection, growth cone. Cell projection, axon.
• Protein Description: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3..
• Protein Sequence: MASTVSAYKEKMKELSVLSLICSCFYSQPHPNTIYQYGDMEVKQLDKRASGQSFEVILKSPSDLSPESPVLSSPPKRKDASLEELQKRLEAAEERRKTQEAQVLKQLAERREHEREVLHKALEENNNFSRLAEEKLNYKMELSKEIREAHLAALRERLREKELHAAEVRRNKEQREEMSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	ASTVSAYKEKMKELS CCHHHHHHHHHHHHH	51.04	22790023
11	Ubiquitination	TVSAYKEKMKELSVL HHHHHHHHHHHHHHH	51.63	22790023
22	S-palmitoylation	LSVLSLICSCFYSQP HHHHHHHHHHHHCCC	3.34	-
24	S-palmitoylation	VLSLICSCFYSQPHP HHHHHHHHHHCCCCC	3.00	-
50	Phosphorylation	KQLDKRASGQSFEVI HHHCCCCCCCCEEEE	41.20	25521595
53	Phosphorylation	DKRASGQSFEVILKS CCCCCCCCEEEEECC	27.22	25521595
60	Phosphorylation	SFEVILKSPSDLSPE CEEEEECCHHHCCCC	26.62	25521595
62	Phosphorylation	EVILKSPSDLSPESP EEEECCHHHCCCCCC	59.27	25521595
65	Phosphorylation	LKSPSDLSPESPVLS ECCHHHCCCCCCCCC	31.45	25521595
68	Phosphorylation	PSDLSPESPVLSSPP HHHCCCCCCCCCCCC	24.56	25521595
72	Phosphorylation	SPESPVLSSPPKRKD CCCCCCCCCCCCCCC	40.82	24925903
73	Phosphorylation	PESPVLSSPPKRKDA CCCCCCCCCCCCCCC	40.85	25521595
78	Ubiquitination	LSSPPKRKDASLEEL CCCCCCCCCCCHHHH	64.87	22790023
81	Phosphorylation	PPKRKDASLEELQKR CCCCCCCCHHHHHHH	46.58	25521595
87	Ubiquitination	ASLEELQKRLEAAEE CCHHHHHHHHHHHHH	72.13	22790023
98	Phosphorylation	AAEERRKTQEAQVLK HHHHHHHHHHHHHHH	29.81	-
105	Ubiquitination	TQEAQVLKQLAERRE HHHHHHHHHHHHHHH	44.39	22790023
129	Phosphorylation	LEENNNFSRLAEEKL HHHCCCHHHHHHHHH	28.62	28066266
135	Ubiquitination	FSRLAEEKLNYKMEL HHHHHHHHHHHHHHH	33.27	22790023
179	Phosphorylation	KEQREEMSG------ HHHHHHHCC------	44.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STMN3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STMN3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STMN3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STMN3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, AND MASSSPECTROMETRY.
PubMed: 17114649

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65; SER-68 AND SER-73,AND MASS SPECTROMETRY.
PubMed: 15345747