STX1B_MOUSE - dbPTM
STX1B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STX1B_MOUSE
UniProt AC P61264
Protein Name Syntaxin-1B
Gene Name Stx1b
Organism Mus musculus (Mouse).
Sequence Length 288
Subcellular Localization Membrane
Single-pass type IV membrane protein .
Protein Description Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm..
Protein Sequence MKDRTQELRSAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDDIKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDMAMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGVVLASSIGGTLGL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MKDRTQELRSAK
---CCHHHHHHHHCC		36.2129899451
10PhosphorylationDRTQELRSAKDSDDE
HHHHHHHHCCCCCCH		52.9025521595
14PhosphorylationELRSAKDSDDEEEVV
HHHHCCCCCCHHHEE		46.3725521595
45UbiquitinationEIRGCIEKLSEDVEQ
HHHHHHHHHHHHHHH		37.0822790023
50UbiquitinationIEKLSEDVEQVKKQH
HHHHHHHHHHHHHHH		4.9427667366
54UbiquitinationSEDVEQVKKQHSAIL
HHHHHHHHHHHHHHH		46.5422790023
55UbiquitinationEDVEQVKKQHSAILA
HHHHHHHHHHHHHHH		55.1522790023
58PhosphorylationEQVKKQHSAILAAPN
HHHHHHHHHHHHCCC		17.9525521595
65UbiquitinationSAILAAPNPDEKTKQ
HHHHHCCCCCHHHHH		52.5127667366
69UbiquitinationAAPNPDEKTKQELED
HCCCCCHHHHHHHHH		69.2922790023
71UbiquitinationPNPDEKTKQELEDLT
CCCCHHHHHHHHHHH		53.4922790023
82AcetylationEDLTADIKKTANKVR
HHHHHHHHHHHHHHH		44.628264491
82UbiquitinationEDLTADIKKTANKVR
HHHHHHHHHHHHHHH		44.6222790023
89UbiquitinationKKTANKVRSKLKAIE
HHHHHHHHHHHHHHH		29.6827667366
93UbiquitinationNKVRSKLKAIEQSIE
HHHHHHHHHHHHHHH		51.5622790023
98PhosphorylationKLKAIEQSIEQEEGL
HHHHHHHHHHHHHCC		18.4625521595
108PhosphorylationQEEGLNRSSADLRIR
HHHCCCCCCHHHHHH		28.8929899451
109PhosphorylationEEGLNRSSADLRIRK
HHCCCCCCHHHHHHH		23.6722817900
125UbiquitinationQHSTLSRKFVEVMTE
HCCHHHHHHHHHHHH		50.8422790023
136PhosphorylationVMTEYNATQSKYRDR
HHHHCCCCHHHHHHH		29.7229899451
139UbiquitinationEYNATQSKYRDRCKD
HCCCCHHHHHHHHHH		34.1922790023
155PhosphorylationIQRQLEITGRTTTNE
HHHHHHHHCCCCCHH		15.9624925903
158PhosphorylationQLEITGRTTTNEELE
HHHHHCCCCCHHHHH		39.0422871156
159PhosphorylationLEITGRTTTNEELED
HHHHCCCCCHHHHHH		26.6829899451
160PhosphorylationEITGRTTTNEELEDM
HHHCCCCCHHHHHHH		39.7725521595
170PhosphorylationELEDMLESGKLAIFT
HHHHHHHHCCEEEEC		36.9529899451
172UbiquitinationEDMLESGKLAIFTDD
HHHHHHCCEEEECCC		43.9822790023
177UbiquitinationSGKLAIFTDDIKMDS
HCCEEEECCCCCCCH		27.0127667366
181UbiquitinationAIFTDDIKMDSQMTK
EEECCCCCCCHHHHH		43.5822790023
184UbiquitinationTDDIKMDSQMTKQAL
CCCCCCCHHHHHHHH		20.5327667366
187UbiquitinationIKMDSQMTKQALNEI
CCCCHHHHHHHHHHH		16.6227667366
188UbiquitinationKMDSQMTKQALNEIE
CCCHHHHHHHHHHHH		28.3822790023
203UbiquitinationTRHNEIIKLETSIRE
HHHHHHHHHHHHHHH		46.0322790023
206PhosphorylationNEIIKLETSIRELHD
HHHHHHHHHHHHHHH		39.6319854140
211UbiquitinationLETSIRELHDMFVDM
HHHHHHHHHHHHHHH		2.7427667366
224PhosphorylationDMAMLVESQGEMIDR
HHHHHHHCCCCEECE		35.6919854140
248UbiquitinationDYVERAVSDTKKAVK
HHHHHHHHHHHHHHH		38.2827667366
251UbiquitinationERAVSDTKKAVKYQS
HHHHHHHHHHHHHHC		43.6627667366
252UbiquitinationRAVSDTKKAVKYQSK
HHHHHHHHHHHHHCH		61.5827667366
255UbiquitinationSDTKKAVKYQSKARR
HHHHHHHHHHCHHHH		42.2927667366
299Ubiquitination------------------
------------------		27667366
306Ubiquitination-------------------------
-------------------------		27667366
370Ubiquitination-----------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------		27667366
373Ubiquitination--------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------		27667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STX1B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STX1B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STX1B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of STX1B_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STX1B_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-58 AND THR-160,AND MASS SPECTROMETRY.
"Quantitative analysis of both protein expression and serine /threonine post-translational modifications through stable isotopelabeling with dithiothreitol.";
Vosseller K., Hansen K.C., Chalkley R.J., Trinidad J.C., Wells L.,Hart G.W., Burlingame A.L.;
Proteomics 5:388-398(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND MASSSPECTROMETRY.

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