GBB3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBB3_MOUSE
• UniProt AC: Q61011
• Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
• Gene Name: Gnb3
• Organism: Mus musculus (Mouse).
• Sequence Length: 340
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction..
• Protein Sequence: MGEMEQLRQEAEQLKKQIADARKACADITLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSQESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSLKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	VQMRTRRTLRGHLAK EECCCCHHHHHHHHH	19.95	25521595
65	Phosphorylation	IYAMHWATDSKLLVS HHHHHHHCCCCEEEE	35.30	21454597
67	Phosphorylation	AMHWATDSKLLVSAS HHHHHCCCCEEEEEC	22.35	21454597
74	Phosphorylation	SKLLVSASQDGKLIV CCEEEEECCCCCEEE	22.69	21454597
136	Phosphorylation	REGNVKVSRELSAHT CCCCCEECHHHHCCC	17.83	-
177	Ubiquitination	DIETGQQKTVFVGHT EECCCCEEEEEEECC	38.48	-
262	Phosphorylation	LRADQELTAYSQESI ECCCCHHEEECCCEE	23.85	25367039
264	Phosphorylation	ADQELTAYSQESIIC CCCHHEEECCCEEHH	12.97	25367039
265	Phosphorylation	DQELTAYSQESIICG CCHHEEECCCEEHHC	25.63	25367039
268	Phosphorylation	LTAYSQESIICGITS HEEECCCEEHHCHHH	15.04	25367039
274	Phosphorylation	ESIICGITSVAFSLS CEEHHCHHHEEECCC	11.48	25367039
275	Phosphorylation	SIICGITSVAFSLSG EEHHCHHHEEECCCC	14.99	25367039
279	Phosphorylation	GITSVAFSLSGRLLF CHHHEEECCCCCEEE	16.34	25367039
281	Phosphorylation	TSVAFSLSGRLLFAG HHEEECCCCCEEEEE	22.22	25367039
289	Phosphorylation	GRLLFAGYDDFNCNV CCEEEEECCCCCCCC	14.65	25367039
299	Phosphorylation	FNCNVWDSLKCERVG CCCCCHHHCCCEEEE	17.64	25367039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBB3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBB3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBB3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GBB3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative analysis of both protein expression and serine /threonine post-translational modifications through stable isotopelabeling with dithiothreitol.";
Vosseller K., Hansen K.C., Chalkley R.J., Trinidad J.C., Wells L.,Hart G.W., Burlingame A.L.;
Proteomics 5:388-398(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND MASSSPECTROMETRY.
PubMed: 15648052