UniProt ID | DYN1_MOUSE | |
---|---|---|
UniProt AC | P39053 | |
Protein Name | Dynamin-1 | |
Gene Name | Dnm1 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 867 | |
Subcellular Localization | Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated. | |
Protein Description | Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).. | |
Protein Sequence | MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNSTTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKIAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVDEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSLGAWRLNSPQGKHENRAGKARL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
45 | Phosphorylation | GGQSAGKSSVLENFV CCCCCCCHHHHHHHC | 25.43 | 25521595 | |
46 | Phosphorylation | GQSAGKSSVLENFVG CCCCCCHHHHHHHCC | 33.92 | 25521595 | |
61 | Phosphorylation | RDFLPRGSGIVTRRP CCCCCCCCCCCCCCC | 26.99 | 29899451 | |
76 | Phosphorylation | LVLQLVNSTTEYAEF CHHHHHCCCHHHHHH | 29.26 | 29899451 | |
77 | Phosphorylation | VLQLVNSTTEYAEFL HHHHHCCCHHHHHHH | 20.60 | 29899451 | |
80 | Phosphorylation | LVNSTTEYAEFLHCK HHCCCHHHHHHHCCC | 14.89 | 29899451 | |
86 | S-nitrosocysteine | EYAEFLHCKGKKFTD HHHHHHCCCCCCCCC | 7.27 | - | |
86 | S-nitrosylation | EYAEFLHCKGKKFTD HHHHHHCCCCCCCCC | 7.27 | 19101475 | |
86 | S-palmitoylation | EYAEFLHCKGKKFTD HHHHHHCCCCCCCCC | 7.27 | 28680068 | |
92 | Phosphorylation | HCKGKKFTDFEEVRL CCCCCCCCCHHHEEE | 48.97 | - | |
111 | Phosphorylation | ETDRVTGTNKGISPV ECCCCCCCCCCCCCC | 25.13 | 18779572 | |
125 | Nitrated tyrosine | VPINLRVYSPHVLNL CCEEEEEECCEEEEE | 15.28 | - | |
125 | Phosphorylation | VPINLRVYSPHVLNL CCEEEEEECCEEEEE | 15.28 | 20415495 | |
125 | Nitration | VPINLRVYSPHVLNL CCEEEEEECCEEEEE | 15.28 | 16800626 | |
125 | Nitration | VPINLRVYSPHVLNL CCEEEEEECCEEEEE | 15.28 | 16800626 | |
126 | Phosphorylation | PINLRVYSPHVLNLT CEEEEEECCEEEEEE | 12.98 | 29899451 | |
175 | Phosphorylation | NCLILAVSPANSDLA CEEEEEECCCCCCCC | 16.82 | 25521595 | |
200 | Phosphorylation | VDPQGQRTIGVITKL CCCCCCEEEEEEEEH | 17.75 | 28059163 | |
206 (in isoform 4) | Ubiquitination | - | 28.95 | 22790023 | |
206 | Ubiquitination | RTIGVITKLDLMDEG EEEEEEEEHHHCCCC | 28.95 | 22790023 | |
223 | Ubiquitination | ARDVLENKLLPLRRG HHHHHHHCCCCCCCC | 41.86 | 22790023 | |
223 (in isoform 4) | Ubiquitination | - | 41.86 | 22790023 | |
231 | Phosphorylation | LLPLRRGYIGVVNRS CCCCCCCCEEEEECC | 7.84 | 18779572 | |
238 | Phosphorylation | YIGVVNRSQKDIDGK CEEEEECCHHCCCCC | 36.06 | 18779572 | |
257 | Ubiquitination | AALAAERKFFLSHPS HHHHHHHHHHHCCHH | 31.79 | 22790023 | |
257 (in isoform 4) | Ubiquitination | - | 31.79 | 22790023 | |
261 | Phosphorylation | AERKFFLSHPSYRHL HHHHHHHCCHHHHHH | 28.35 | - | |
264 | Phosphorylation | KFFLSHPSYRHLADR HHHHCCHHHHHHHHH | 29.40 | - | |
265 | Nitration | FFLSHPSYRHLADRM HHHCCHHHHHHHHHC | 13.40 | - | |
299 (in isoform 4) | Ubiquitination | - | 41.28 | 22790023 | |
299 | Ubiquitination | TLPGLRNKLQSQLLS HCHHHHHHHHHHHHH | 41.28 | 22790023 | |
302 | Phosphorylation | GLRNKLQSQLLSIEK HHHHHHHHHHHHHHH | 32.98 | 20415495 | |
306 | Phosphorylation | KLQSQLLSIEKEVDE HHHHHHHHHHHHHHH | 36.98 | 19060867 | |
309 (in isoform 4) | Ubiquitination | - | 62.46 | 22790023 | |
309 | Ubiquitination | SQLLSIEKEVDEYKN HHHHHHHHHHHHHHC | 62.46 | 22790023 | |
315 | Ubiquitination | EKEVDEYKNFRPDDP HHHHHHHHCCCCCCH | 47.78 | 22790023 | |
315 (in isoform 4) | Ubiquitination | - | 47.78 | 22790023 | |
342 | Ubiquitination | QFAVDFEKRIEGSGD HHHHCHHHHCCCCCC | 59.68 | - | |
347 | Phosphorylation | FEKRIEGSGDQIDTY HHHHCCCCCCCCEEE | 26.80 | 25521595 | |
353 | Phosphorylation | GSGDQIDTYELSGGA CCCCCCEEEEECCCC | 22.11 | 29899451 | |
354 | Phosphorylation | SGDQIDTYELSGGAR CCCCCEEEEECCCCC | 15.89 | 15592455 | |
354 | Nitration | SGDQIDTYELSGGAR CCCCCEEEEECCCCC | 15.89 | - | |
376 (in isoform 4) | Ubiquitination | - | 45.39 | 22790023 | |
376 | Ubiquitination | RFPFELVKMEFDEKE CCCHHHEECCCCHHH | 45.39 | 22790023 | |
382 (in isoform 4) | Ubiquitination | - | 64.99 | 22790023 | |
382 | Ubiquitination | VKMEFDEKELRREIS EECCCCHHHHHHHHH | 64.99 | 22790023 | |
393 (in isoform 4) | Ubiquitination | - | 41.50 | 22790023 | |
393 | Ubiquitination | REISYAIKNIHGIRT HHHHHHHHHHHCCCC | 41.50 | 22790023 | |
400 (in isoform 3) | Phosphorylation | - | 35.99 | 22324799 | |
404 (in isoform 3) | Phosphorylation | - | 24.34 | 20415495 | |
412 (in isoform 3) | Phosphorylation | - | 3.17 | 22324799 | |
414 (in isoform 3) | Ubiquitination | - | 33.37 | - | |
449 | Phosphorylation | CTKKLQQYPRLREEM HHHHHHHCHHHHHHH | 4.20 | - | |
511 | Phosphorylation | NQMNKKKTSGNQDEI HHHCCCCCCCCCCCE | 51.23 | 25521595 | |
512 | Phosphorylation | QMNKKKTSGNQDEIL HHCCCCCCCCCCCEE | 44.63 | 25521595 | |
535 (in isoform 4) | Ubiquitination | - | 59.19 | 22790023 | |
535 | Ubiquitination | INNIGIMKGGSKEYW EECEEEECCCCEEEE | 59.19 | 22790023 | |
538 | Phosphorylation | IGIMKGGSKEYWFVL EEEECCCCEEEEEEE | 30.86 | - | |
563 | Phosphorylation | DEEKEKKYMLSVDNL HHHHHHHEEEEEECC | 17.85 | 25521595 | |
566 | Phosphorylation | KEKKYMLSVDNLKLR HHHHEEEEEECCCCH | 15.76 | 25521595 | |
571 (in isoform 4) | Ubiquitination | - | 47.97 | 22790023 | |
571 | Ubiquitination | MLSVDNLKLRDVEKG EEEEECCCCHHHHHH | 47.97 | 22790023 | |
619 | Phosphorylation | EVDSWKASFLRAGVY HHHHHHHHHHHHCCC | 22.53 | 24704852 | |
635 (in isoform 4) | Ubiquitination | - | 64.05 | 22790023 | |
635 | Ubiquitination | ERVGDKEKASETEEN HHCCCHHHCCCCCCC | 64.05 | 22790023 | |
639 | Phosphorylation | DKEKASETEENGSDS CHHHCCCCCCCCCCC | 46.21 | 29899451 | |
644 | Phosphorylation | SETEENGSDSFMHSM CCCCCCCCCCCHHHC | 41.48 | 29899451 | |
650 | Phosphorylation | GSDSFMHSMDPQLER CCCCCHHHCCHHHHH | 17.06 | - | |
676 | Phosphorylation | YMAIVNKTVRDLMPK HHHHHCHHHHHHCCH | 18.64 | 18779572 | |
761 | Phosphorylation | MPPPVDDSWLQVQSV CCCCCCCCCEEEECC | 25.81 | 29899451 | |
767 | Phosphorylation | DSWLQVQSVPAGRRS CCCEEEECCCCCCCC | 31.08 | 29899451 | |
774 | Phosphorylation | SVPAGRRSPTSSPTP CCCCCCCCCCCCCCC | 31.04 | 25521595 | |
776 | Phosphorylation | PAGRRSPTSSPTPQR CCCCCCCCCCCCCCC | 42.98 | 25521595 | |
777 | Phosphorylation | AGRRSPTSSPTPQRR CCCCCCCCCCCCCCC | 37.39 | 25521595 | |
778 | Phosphorylation | GRRSPTSSPTPQRRA CCCCCCCCCCCCCCC | 34.96 | 25521595 | |
780 | Phosphorylation | RSPTSSPTPQRRAPA CCCCCCCCCCCCCCC | 33.72 | 27742792 | |
795 | Phosphorylation | VPPARPGSRGPAPGP CCCCCCCCCCCCCCC | 36.43 | 28418008 | |
796 | Methylation | PPARPGSRGPAPGPP CCCCCCCCCCCCCCC | 62.11 | 24129315 | |
807 | Phosphorylation | PGPPPAGSALGGAPP CCCCCCCCCCCCCCC | 23.56 | 25777480 | |
817 (in isoform 5) | Phosphorylation | - | 51.87 | 29899451 | |
817 | Phosphorylation | GGAPPVPSRPGASPD CCCCCCCCCCCCCCC | 51.87 | 21659605 | |
817 (in isoform 3) | Phosphorylation | - | 51.87 | 29899451 | |
822 (in isoform 3) | Phosphorylation | - | 35.43 | 24453211 | |
822 (in isoform 5) | Phosphorylation | - | 35.43 | 24453211 | |
822 | Phosphorylation | VPSRPGASPDPFGPP CCCCCCCCCCCCCCC | 35.43 | 26160508 | |
830 (in isoform 6) | Phosphorylation | - | 51.43 | 29899451 | |
834 (in isoform 4) | Phosphorylation | - | 62.61 | 29899451 | |
834 | Phosphorylation | GPPPQVPSRPNRAPP CCCCCCCCCCCCCCC | 62.61 | 26160508 | |
845 (in isoform 4) | Phosphorylation | - | 36.71 | 29899451 | |
847 (in isoform 6) | Phosphorylation | - | 27.68 | 26824392 | |
847 (in isoform 4) | Phosphorylation | - | 27.68 | 30372032 | |
849 (in isoform 6) | Phosphorylation | - | 11.96 | 24453211 | |
851 (in isoform 4) | Phosphorylation | - | 5.33 | 22324799 | |
853 (in isoform 4) | Phosphorylation | - | 24.16 | 22324799 | |
857 (in isoform 4) | Phosphorylation | - | 42.36 | 22324799 | |
857 (in isoform 6) | Phosphorylation | - | 42.36 | 26239621 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DYN1_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DYN1_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DYN1_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
KIF2A_MOUSE | Kif2a | physical | 20037577 | |
KIF5A_MOUSE | Kif5a | physical | 20037577 | |
TBA1A_MOUSE | Tuba1a | physical | 20037577 | |
DYN1_MOUSE | Dnm1 | physical | 9463375 | |
SH3G2_MOUSE | Sh3gl2 | physical | 22167186 | |
SH3G1_MOUSE | Sh3gl1 | physical | 22167186 | |
KCMA1_MOUSE | Kcnma1 | physical | 20114047 | |
CLH1_MOUSE | Cltc | physical | 20114047 | |
SH3K1_MOUSE | Sh3kbp1 | physical | 20551902 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Nitration | |
Reference | PubMed |
"Endogenously nitrated proteins in mouse brain: links toneurodegenerative disease."; Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H.,Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J.,Squier T.C., Bigelow D.J.; Biochemistry 45:8009-8022(2006). Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-125, AND MASS SPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-778, AND MASSSPECTROMETRY. | |
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-80; TYR-125 AND TYR-354,AND MASS SPECTROMETRY. |