SH3G2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SH3G2_MOUSE
• UniProt AC: Q62420
• Protein Name: Endophilin-A1 {ECO:0000303|PubMed:21849472}
• Gene Name: Sh3gl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 352
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein . Early endosome . Concentrated in presynaptic nerve terminals in neurons..
• Protein Description: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. [PubMed: 21849472 Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes]
• Protein Sequence: MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDSTQPNGGLSHTGTPKPPGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVALPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVAGLKKQ ------CCHHHHHHH	22.22	22006019
14	Phosphorylation	KKQFHKATQKVSEKV HHHHHHHHHHHHHHH	33.45	29899451
20	Acetylation	ATQKVSEKVGGAEGT HHHHHHHHHCCCCCC	38.38	7718989
41	Ubiquitination	KEMERKVDVTSRAVM HHHHHHCCHHHHHHH	40.80	27667366
73	Phosphorylation	AKLSMINTMSKIRGQ HHHHHHHHHHHHCCC	16.34	22324799
75	Phosphorylation	LSMINTMSKIRGQEK HHHHHHHHHHCCCCC	23.92	22324799
76	Ubiquitination	SMINTMSKIRGQEKG HHHHHHHHHCCCCCC	26.12	27667366
142	Ubiquitination	VKQNFIDPLQNLHDK HHHHHHHHHHHCCHH	30.91	27667366
170	Phosphorylation	GRRLDFDYKKKRQGK CCCCCCCHHHHHCCC	25.38	29514104
177	Ubiquitination	YKKKRQGKIPDEELR HHHHHCCCCCHHHHH	42.60	27667366
223	Ubiquitination	SALVQAQLEYHKQAV HHHHHHHHHHHHHHH	8.71	27667366
258	Ubiquitination	PRREYQPKPRMSLEF CCCCCCCCCCEEEEE	29.72	27667366
262	Phosphorylation	YQPKPRMSLEFATGD CCCCCCEEEEEECCC	26.48	19060867
267	Phosphorylation	RMSLEFATGDSTQPN CEEEEEECCCCCCCC	47.01	29899451
270	Phosphorylation	LEFATGDSTQPNGGL EEEECCCCCCCCCCC	30.22	22807455
280	Phosphorylation	PNGGLSHTGTPKPPG CCCCCCCCCCCCCCC	39.10	29899451
282	Phosphorylation	GGLSHTGTPKPPGVQ CCCCCCCCCCCCCCC	29.33	29899451
299	Phosphorylation	QPCCRALYDFEPENE CCCEEECCCCCCCCC	20.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SH3G2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SH3G2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SH3G2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRKN_MOUSE	Park2	physical	20064468
ATX2_MOUSE	Atxn2	physical	18602463
SH3K1_MOUSE	Sh3kbp1	physical	20551902
AMPH_MOUSE	Amph	physical	12456676
BIN1_MOUSE	Bin1	physical	12456676
DYN1_MOUSE	Dnm1	physical	12456676
SYN1_MOUSE	Syn1	physical	12456676

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.