ATX2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATX2_MOUSE
• UniProt AC: O70305
• Protein Name: Ataxin-2
• Gene Name: Atxn2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1285
• Subcellular Localization: Cytoplasm .
• Protein Description: Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane..
• Protein Sequence: MRSSTAAVQRPAAGDPEPRRPAGWAARRSLPRTARRGGRGGAVAYPSAGPPPRGPGAPPRGPRSPPCASDCFGSNGHGASRPGSRRLLGVCGPPRPFVVVLLALAPAATPARACPPGVRASPPRSGVSSSARPAPGCPRPACEPVYGPLTMSLKPQPQPPAPATGRKPGGGLLSSPGAAPASAAVTSASVVPAPAAPVASSSAAAGGGRPGLGRGRNSSKGLPQPTISFDGIYANVRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESVLFKCSDFVVVQFKDTDSSYARRDAFTDSALSAKVNGEHKEKDLEPWDAGELTASEELELENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNCSDREGHGPNTRDNKYIPPGQRNREVLSWGSGRQSSPRMGQPGPGSMPSRAASHTSDFNPNAGSDQRVVNGGVPWPSPCPSHSSRPPSRYQSGPNSLPPRAATHTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSMSSGLEFVSHNPPSEAAAPPVARTSPAGGTWSSVVSGVPRLSPKTHRPRSPRQSSIGNSPSGPVLASPQAGIIPAEAVSMPVPAASPTPASPASNRALTPSIEAKDSRLQDQRQNSPAGSKENVKASETSPSFSKADNKGMSPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLSKNREGEKSRDLIKDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSISPSMLSNAEHKRGPEVTSQGVQTSSPACKQEKDDREEKKDTTEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNAALHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQSSFPAAQQTVFTIHPSHVQPAYTTPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGPKAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
121	Phosphorylation	CPPGVRASPPRSGVS CCCCCCCCCCCCCCC	25.52	27149854
186	O-linked_Glycosylation	APASAAVTSASVVPA CCCCCCCEECCCCCC	17.53	28528544
187	O-linked_Glycosylation	PASAAVTSASVVPAP CCCCCCEECCCCCCC	16.37	28528544
209	Methylation	SAAAGGGRPGLGRGR CCCCCCCCCCCCCCC	25.95	-
216	Methylation	RPGLGRGRNSSKGLP CCCCCCCCCCCCCCC	38.20	-
218	Phosphorylation	GLGRGRNSSKGLPQP CCCCCCCCCCCCCCC	31.87	21659605
219	Phosphorylation	LGRGRNSSKGLPQPT CCCCCCCCCCCCCCC	34.00	22817900
233	Phosphorylation	TISFDGIYANVRMVH CEEECCEEEEEEEEE	9.54	22817900
260	Phosphorylation	QVKNGGIYEGVFKTY EEECCCEEEEEEECC	15.20	25367039
329	Phosphorylation	AFTDSALSAKVNGEH HCCHHHHHHHHCCCC	26.26	30352176
362	Phosphorylation	LELENDVSNGWDPND EEECCCCCCCCCHHH	32.27	-
389	Phosphorylation	STYDSSLSSYTVPLE EEECCCCCEEEEECC	24.21	26643407
390	Phosphorylation	TYDSSLSSYTVPLER EECCCCCEEEEECCC	30.07	26643407
391	Phosphorylation	YDSSLSSYTVPLERD ECCCCCEEEEECCCC	14.37	26643407
392	Phosphorylation	DSSLSSYTVPLERDN CCCCCEEEEECCCCC	20.00	26643407
400	Phosphorylation	VPLERDNSEEFLKRE EECCCCCCHHHHHHH	42.67	25521595
424	Ubiquitination	IESSAQYKARVALEN HHHHHHHHHHHHHHC	20.03	-
435	Phosphorylation	ALENDDRSEEEKYTA HHHCCCCCHHHHHHH	57.25	27087446
440	Phosphorylation	DRSEEEKYTAVQRNC CCCHHHHHHHHHHHC	11.83	22817900
441	Phosphorylation	RSEEEKYTAVQRNCS CCHHHHHHHHHHHCC	31.27	25777480
447	S-nitrosocysteine	YTAVQRNCSDREGHG HHHHHHHCCCCCCCC	4.95	-
447	S-nitrosylation	YTAVQRNCSDREGHG HHHHHHHCCCCCCCC	4.95	21278135
448	Phosphorylation	TAVQRNCSDREGHGP HHHHHHCCCCCCCCC	43.16	23684622
477	Phosphorylation	REVLSWGSGRQSSPR CCEEECCCCCCCCCC	25.25	22817900
499	Phosphorylation	SMPSRAASHTSDFNP CCCCHHHCCCCCCCC	26.72	26643407
501	Phosphorylation	PSRAASHTSDFNPNA CCHHHCCCCCCCCCC	27.74	26643407
502	Phosphorylation	SRAASHTSDFNPNAG CHHHCCCCCCCCCCC	34.48	29899451
523	Phosphorylation	NGGVPWPSPCPSHSS CCCCCCCCCCCCCCC	34.95	21659605
523 (in isoform 2)	Phosphorylation	-	34.95	29895711
527	Phosphorylation	PWPSPCPSHSSRPPS CCCCCCCCCCCCCCH	42.59	21659605
549	Phosphorylation	SLPPRAATHTRPPSR CCCCCCCCCCCCCCC	23.85	21183079
551	Phosphorylation	PPRAATHTRPPSRPP CCCCCCCCCCCCCCC	40.28	21183079
562	Phosphorylation	SRPPSRPSRPPSHPS CCCCCCCCCCCCCCC	57.20	29233185
566	Phosphorylation	SRPSRPPSHPSAHGS CCCCCCCCCCCCCCC	51.19	23684622
569	Phosphorylation	SRPPSHPSAHGSPAP CCCCCCCCCCCCCCC	27.72	29233185
573	Phosphorylation	SHPSAHGSPAPVSTM CCCCCCCCCCCCCCC	14.18	29233185
578	Phosphorylation	HGSPAPVSTMPKRMS CCCCCCCCCCCCCCC	20.23	29233185
579	Phosphorylation	GSPAPVSTMPKRMSS CCCCCCCCCCCCCCC	37.41	29233185
585	Phosphorylation	STMPKRMSSEGPPRM CCCCCCCCCCCCCCC	29.30	25266776
586	Phosphorylation	TMPKRMSSEGPPRMS CCCCCCCCCCCCCCC	36.91	21183079
593	Phosphorylation	SEGPPRMSPKAQRHP CCCCCCCCHHHHCCC	25.24	26824392
598	Dimethylation	RMSPKAQRHPRNHRV CCCHHHHCCCCCCCC	46.79	-
601	Dimethylation	PKAQRHPRNHRVSAG HHHHCCCCCCCCCCC	45.52	-
609	Asymmetric dimethylarginine	NHRVSAGRGSMSSGL CCCCCCCCCCHHCCC	33.46	-
609	Methylation	NHRVSAGRGSMSSGL CCCCCCCCCCHHCCC	33.46	24129315
611	Phosphorylation	RVSAGRGSMSSGLEF CCCCCCCCHHCCCEE	17.71	29472430
613	Phosphorylation	SAGRGSMSSGLEFVS CCCCCCHHCCCEEHH	23.97	17242355
614	Phosphorylation	AGRGSMSSGLEFVSH CCCCCHHCCCEEHHC	38.46	29472430
635	Phosphorylation	AAPPVARTSPAGGTW CCCCCCCCCCCCCCH	29.35	24925903
636	Phosphorylation	APPVARTSPAGGTWS CCCCCCCCCCCCCHH	13.75	25521595
641	Phosphorylation	RTSPAGGTWSSVVSG CCCCCCCCHHHHHCC	22.66	24925903
643	Phosphorylation	SPAGGTWSSVVSGVP CCCCCCHHHHHCCCC	17.06	24925903
644	Phosphorylation	PAGGTWSSVVSGVPR CCCCCHHHHHCCCCC	20.35	24925903
647	Phosphorylation	GTWSSVVSGVPRLSP CCHHHHHCCCCCCCC	31.73	24453211
653	Phosphorylation	VSGVPRLSPKTHRPR HCCCCCCCCCCCCCC	26.15	25521595
656	Phosphorylation	VPRLSPKTHRPRSPR CCCCCCCCCCCCCCC	26.88	25159016
661	Phosphorylation	PKTHRPRSPRQSSIG CCCCCCCCCCCCCCC	27.41	27149854
665	Phosphorylation	RPRSPRQSSIGNSPS CCCCCCCCCCCCCCC	25.79	25619855
666	Phosphorylation	PRSPRQSSIGNSPSG CCCCCCCCCCCCCCC	26.61	25619855
670	Phosphorylation	RQSSIGNSPSGPVLA CCCCCCCCCCCCCCC	18.41	25619855
672	Phosphorylation	SSIGNSPSGPVLASP CCCCCCCCCCCCCCC	56.39	25619855
678	Phosphorylation	PSGPVLASPQAGIIP CCCCCCCCCCCCCEE	17.24	25619855
690	Phosphorylation	IIPAEAVSMPVPAAS CEEHHHHCCCCCCCC	25.15	25619855
697	Phosphorylation	SMPVPAASPTPASPA CCCCCCCCCCCCCCC	31.26	25521595
699	Phosphorylation	PVPAASPTPASPASN CCCCCCCCCCCCCCC	29.05	22942356
702	Phosphorylation	AASPTPASPASNRAL CCCCCCCCCCCCCCC	23.39	25168779
705	Phosphorylation	PTPASPASNRALTPS CCCCCCCCCCCCCCC	30.17	25619855
710	Phosphorylation	PASNRALTPSIEAKD CCCCCCCCCCHHHHH	17.63	25521595
712	Phosphorylation	SNRALTPSIEAKDSR CCCCCCCCHHHHHHH	28.03	25619855
718	Phosphorylation	PSIEAKDSRLQDQRQ CCHHHHHHHHHHHHH	33.90	22324799
727	Phosphorylation	LQDQRQNSPAGSKEN HHHHHHCCCCCCHHH	14.05	27087446
731	Phosphorylation	RQNSPAGSKENVKAS HHCCCCCCHHHHCCC	38.61	26745281
738	Phosphorylation	SKENVKASETSPSFS CHHHHCCCCCCCCCC	35.37	25159016
740	Phosphorylation	ENVKASETSPSFSKA HHHCCCCCCCCCCHH	43.36	27149854
741	Phosphorylation	NVKASETSPSFSKAD HHCCCCCCCCCCHHC	17.94	27087446
743	Phosphorylation	KASETSPSFSKADNK CCCCCCCCCCHHCCC	41.75	23375375
745	O-linked_Glycosylation	SETSPSFSKADNKGM CCCCCCCCHHCCCCC	31.13	72500853
745	Phosphorylation	SETSPSFSKADNKGM CCCCCCCCHHCCCCC	31.13	25159016
753	Phosphorylation	KADNKGMSPVVSEHR HHCCCCCCHHHHHHH	24.18	26824392
757	Phosphorylation	KGMSPVVSEHRKQID CCCCHHHHHHHHHHH	28.11	23984901
778	Phosphorylation	NDFRLQPSSTSESMD CCCCCCCCCCCHHHH	33.03	23984901
779	Phosphorylation	DFRLQPSSTSESMDQ CCCCCCCCCCHHHHH	42.51	23984901
780	Phosphorylation	FRLQPSSTSESMDQL CCCCCCCCCHHHHHH	40.63	23984901
781	Phosphorylation	RLQPSSTSESMDQLL CCCCCCCCHHHHHHH	29.62	23984901
783	Phosphorylation	QPSSTSESMDQLLSK CCCCCCHHHHHHHHC	27.68	25521595
790	Ubiquitination	SMDQLLSKNREGEKS HHHHHHHCCCCCHHH	61.05	-
812	Phosphorylation	TEASAKDSFIDSSSS HHHHHHHHHCCCCCC	24.32	25293948
816	Phosphorylation	AKDSFIDSSSSSSNC HHHHHCCCCCCCCCC	27.57	25293948
817	Phosphorylation	KDSFIDSSSSSSNCT HHHHCCCCCCCCCCC	30.41	25619855
818	Phosphorylation	DSFIDSSSSSSNCTS HHHCCCCCCCCCCCC	37.89	25619855
819	Phosphorylation	SFIDSSSSSSNCTSG HHCCCCCCCCCCCCC	39.47	25619855
820	Phosphorylation	FIDSSSSSSNCTSGS HCCCCCCCCCCCCCC	27.76	25619855
821	Phosphorylation	IDSSSSSSNCTSGSS CCCCCCCCCCCCCCC	37.56	25619855
824	Phosphorylation	SSSSSNCTSGSSKTN CCCCCCCCCCCCCCC	40.13	25619855
825	Phosphorylation	SSSSNCTSGSSKTNS CCCCCCCCCCCCCCC	38.59	25619855
827	Phosphorylation	SSNCTSGSSKTNSPS CCCCCCCCCCCCCCC	28.55	27087446
828	Phosphorylation	SNCTSGSSKTNSPSI CCCCCCCCCCCCCCC	47.20	25521595
830	Phosphorylation	CTSGSSKTNSPSISP CCCCCCCCCCCCCCH	42.76	27087446
832	Phosphorylation	SGSSKTNSPSISPSM CCCCCCCCCCCCHHH	25.84	25521595
834	Phosphorylation	SSKTNSPSISPSMLS CCCCCCCCCCHHHHC	35.20	27087446
836	Phosphorylation	KTNSPSISPSMLSNA CCCCCCCCHHHHCCC	18.43	18388127
838	Phosphorylation	NSPSISPSMLSNAEH CCCCCCHHHHCCCCH	26.09	27087446
841	Phosphorylation	SISPSMLSNAEHKRG CCCHHHHCCCCHHCC	25.92	27742792
852	O-linked_Glycosylation	HKRGPEVTSQGVQTS HHCCCCCCCCCCCCC	17.42	55410971
852	Phosphorylation	HKRGPEVTSQGVQTS HHCCCCCCCCCCCCC	17.42	-
858	Phosphorylation	VTSQGVQTSSPACKQ CCCCCCCCCCHHHHH	28.85	25619855
859	Phosphorylation	TSQGVQTSSPACKQE CCCCCCCCCHHHHHC	19.75	25619855
860	Phosphorylation	SQGVQTSSPACKQEK CCCCCCCCHHHHHCC	21.65	25521595
882	Acetylation	DTTEQVRKSTLNPNA HHHHHHHHHHCCCCC	49.27	7743605
890	Acetylation	STLNPNAKEFNPRSF HHCCCCCHHCCCCCC	70.27	7743617
896	Phosphorylation	AKEFNPRSFSQPKPS CHHCCCCCCCCCCCC	30.43	25168779
898	Phosphorylation	EFNPRSFSQPKPSTT HCCCCCCCCCCCCCC	46.98	25168779
903	Phosphorylation	SFSQPKPSTTPTSPR CCCCCCCCCCCCCCC	51.55	28066266
904	Phosphorylation	FSQPKPSTTPTSPRP CCCCCCCCCCCCCCC	45.37	28066266
905	Phosphorylation	SQPKPSTTPTSPRPQ CCCCCCCCCCCCCCC	28.98	29472430
907	Phosphorylation	PKPSTTPTSPRPQAQ CCCCCCCCCCCCCCC	49.63	28066266
908	Phosphorylation	KPSTTPTSPRPQAQP CCCCCCCCCCCCCCC	21.81	23384938

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATX2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATX2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATX2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH3G2_MOUSE	Sh3gl2	physical	18602463
SH3K1_MOUSE	Sh3kbp1	physical	18602463
CBL_MOUSE	Cbl	physical	18602463
SRC_MOUSE	Src	physical	18602463

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613; SER-653; SER-741;SER-832 AND SER-836, AND MASS SPECTROMETRY.
PubMed: 17242355