SH3G1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SH3G1_MOUSE
• UniProt AC: Q62419
• Protein Name: Endophilin-A2
• Gene Name: Sh3gl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 368
• Subcellular Localization: Cytoplasm. Early endosome membrane; Peripheral membrane protein. Cell projection, podosome. Associated with postsynaptic endosomes in hippocampal neurons..
• Protein Description: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)..
• Protein Sequence: MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKDMEKKVDVTSKAVAEVLVRTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMVRHGKELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILEELADKLKRRVREASSRPKREFKPRPREPFELGELEQPNGGFPCAPAPKITASSSFRSSDKPIRMPSKSMPPLDQPSCKALYDFEPENDGELGFREGDLITLTNQIDENWYEGMLHGQSGFFPLSYVQVLVPLPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVAGLKKQ ------CCHHHHHHH	22.22	22006019
12	Acetylation	GLKKQFYKASQLVSE HHHHHHHHHHHHHHH	42.73	22826441
14	Phosphorylation	KKQFYKASQLVSEKV HHHHHHHHHHHHHHH	21.64	29514104
20	Acetylation	ASQLVSEKVGGAEGT HHHHHHHHHCCCCCC	38.38	22826441
27	O-linked_Glycosylation	KVGGAEGTKLDDDFK HHCCCCCCCCCHHHH	21.68	30059200
73	Phosphorylation	AKLTMLNTVSKIRGQ HHHEHHHHHHHHHCC	23.38	29514104
75	Phosphorylation	LTMLNTVSKIRGQVK HEHHHHHHHHHCCCC	21.96	29514104
76	Acetylation	TMLNTVSKIRGQVKN EHHHHHHHHHCCCCC	31.89	22826441
76	Ubiquitination	TMLNTVSKIRGQVKN EHHHHHHHHHCCCCC	31.89	-
102	Acetylation	ECMVRHGKELGGESN HHHHHCCHHCCCCCC	43.57	7711841
102	Ubiquitination	ECMVRHGKELGGESN HHHHHCCHHCCCCCC	43.57	-
108	Phosphorylation	GKELGGESNFGDALL CHHCCCCCCHHHHHH	40.51	22817900
122	Acetylation	LDAGESMKRLAEVKD HHHHHHHHHHHHHHH	54.24	7711851
170	Phosphorylation	GRRLDFDYKKKRQGK CCCCCCCHHHHHCCC	25.38	29514104
239	Ubiquitination	ILEELADKLKRRVRE HHHHHHHHHHHHHHH	50.75	-
284	Phosphorylation	CAPAPKITASSSFRS CCCCCCCCCCCCCCC	26.98	26745281
284	O-linked_Glycosylation	CAPAPKITASSSFRS CCCCCCCCCCCCCCC	26.98	30059200
286	Phosphorylation	PAPKITASSSFRSSD CCCCCCCCCCCCCCC	20.19	23684622
287	Phosphorylation	APKITASSSFRSSDK CCCCCCCCCCCCCCC	30.91	27087446
288	Phosphorylation	PKITASSSFRSSDKP CCCCCCCCCCCCCCC	23.37	26824392
291	Phosphorylation	TASSSFRSSDKPIRM CCCCCCCCCCCCCCC	40.66	26239621
292	Phosphorylation	ASSSFRSSDKPIRMP CCCCCCCCCCCCCCC	45.45	26239621
300	Phosphorylation	DKPIRMPSKSMPPLD CCCCCCCCCCCCCCC	28.19	25266776
302	Phosphorylation	PIRMPSKSMPPLDQP CCCCCCCCCCCCCCC	40.64	24719451
315	Phosphorylation	QPSCKALYDFEPEND CCCCCCCCCCCCCCC	24.36	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
315	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SH3G1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SH3G1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SH3G1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, AND MASSSPECTROMETRY.
PubMed: 17242355