UniProt ID | KIF2A_MOUSE | |
---|---|---|
UniProt AC | P28740 | |
Protein Name | Kinesin-like protein KIF2A | |
Gene Name | Kif2a | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 705 | |
Subcellular Localization | Cytoplasm. Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, spindle. Lysosome . Localized to the spindle microtubules and spindle poles fro | |
Protein Description | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity).. | |
Protein Sequence | MATANFGKIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPDEDIEPSPELPPPSSSSKVNKIVKNRRTVAAVKNDPPPRDNRVVGSARARPSQLPEQSSSAQQNGSVSDISPVQAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRAQDVDATNPNYEIMCMIRDFRGSLDYRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVNPAAAGDVHPIMHHPPSQIDDLETQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWIEDEKALLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDKVKSFRAALQEEEQASKQINPKRPRAL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
75 | Phosphorylation | PDEDIEPSPELPPPS CCCCCCCCCCCCCCC | 20.44 | 25293948 | |
82 | Phosphorylation | SPELPPPSSSSKVNK CCCCCCCCCCHHHHH | 48.93 | 26643407 | |
83 | Phosphorylation | PELPPPSSSSKVNKI CCCCCCCCCHHHHHH | 44.39 | 26643407 | |
84 | Phosphorylation | ELPPPSSSSKVNKIV CCCCCCCCHHHHHHH | 38.22 | 26643407 | |
85 | Phosphorylation | LPPPSSSSKVNKIVK CCCCCCCHHHHHHHH | 42.44 | 26643407 | |
93 (in isoform 2) | Phosphorylation | - | 27.98 | 29514104 | |
96 | Phosphorylation | KIVKNRRTVAAVKND HHHHCCCCEEHHCCC | 15.97 | 27149854 | |
99 (in isoform 2) | Phosphorylation | - | 14.42 | 19367708 | |
100 (in isoform 2) | Phosphorylation | - | 4.25 | 27149854 | |
101 | Acetylation | RRTVAAVKNDPPPRD CCCEEHHCCCCCCCC | 51.40 | 23806337 | |
101 (in isoform 2) | Phosphorylation | - | 51.40 | 29899451 | |
126 | Phosphorylation | PSQLPEQSSSAQQNG HHHCCCCCCCCCCCC | 25.29 | 25619855 | |
127 | Phosphorylation | SQLPEQSSSAQQNGS HHCCCCCCCCCCCCC | 29.41 | 25619855 | |
128 | Phosphorylation | QLPEQSSSAQQNGSV HCCCCCCCCCCCCCH | 35.03 | 25619855 | |
134 | Phosphorylation | SSAQQNGSVSDISPV CCCCCCCCHHHCCHH | 26.46 | 25619855 | |
136 | Phosphorylation | AQQNGSVSDISPVQA CCCCCCHHHCCHHHH | 30.81 | 25619855 | |
139 | Phosphorylation | NGSVSDISPVQAAKK CCCHHHCCHHHHHHH | 24.82 | 25521595 | |
156 | Phosphorylation | GPPSRRKSNCVKEVE CCCCCCCCHHHHHHH | 33.38 | - | |
206 | Phosphorylation | MIRDFRGSLDYRPLT EEECCCCCCCCCCCC | 17.51 | 29899451 | |
213 | Phosphorylation | SLDYRPLTTADPIDE CCCCCCCCCCCCCCC | 23.71 | - | |
214 | Phosphorylation | LDYRPLTTADPIDEH CCCCCCCCCCCCCCC | 36.42 | - | |
246 | Phosphorylation | MKDLDVITIPSKDVV CCCCCEEEECCCCEE | 27.04 | - | |
249 | Phosphorylation | LDVITIPSKDVVMVH CCEEEECCCCEEEEC | 37.32 | - | |
272 | Phosphorylation | TRYLENQTFRFDYAF HHHHHCCEEEEEEEE | 28.49 | - | |
282 | Phosphorylation | FDYAFDDSAPNEMVY EEEEECCCCCCCEEE | 47.68 | - | |
327 | Phosphorylation | HTMGGDFSGKNQDCS EECCCCCCCCCCCHH | 54.31 | - | |
466 | Phosphorylation | GNERGADTSSADRQT CCCCCCCCCCCHHHH | 24.85 | - | |
467 | Phosphorylation | NERGADTSSADRQTR CCCCCCCCCCHHHHH | 24.87 | - | |
468 | Phosphorylation | ERGADTSSADRQTRL CCCCCCCCCHHHHHH | 35.96 | - | |
483 | Phosphorylation | EGAEINKSLLALKEC CHHHHHHHHHHHHHH | 24.91 | 22006019 | |
488 | Ubiquitination | NKSLLALKECIRALG HHHHHHHHHHHHHHC | 44.95 | - | |
501 | Phosphorylation | LGRNKPHTPFRASKL HCCCCCCCCCHHHHH | 32.42 | - | |
506 | Phosphorylation | PHTPFRASKLTQVLR CCCCCHHHHHHHHHH | 24.76 | - | |
507 | Ubiquitination | HTPFRASKLTQVLRD CCCCHHHHHHHHHHH | 55.35 | - | |
509 | Phosphorylation | PFRASKLTQVLRDSF CCHHHHHHHHHHHHC | 21.99 | - | |
515 | Phosphorylation | LTQVLRDSFIGENSR HHHHHHHHCCCCCCC | 16.60 | - | |
523 | Phosphorylation | FIGENSRTCMIATIS CCCCCCCEEEEEEEC | 13.27 | 30635358 | |
528 | Phosphorylation | SRTCMIATISPGMAS CCEEEEEEECCCHHH | 15.86 | 30635358 | |
528 (in isoform 1) | Phosphorylation | - | 15.86 | 21183079 | |
530 | Phosphorylation | TCMIATISPGMASCE EEEEEEECCCHHHHH | 15.85 | 30635358 | |
530 (in isoform 1) | Phosphorylation | - | 15.85 | 22807455 | |
535 (in isoform 1) | Phosphorylation | - | 17.05 | 29899451 | |
535 | Phosphorylation | TISPGMASCENTLNT EECCCHHHHHHHHHH | 17.05 | 30635358 | |
539 | Phosphorylation | GMASCENTLNTLRYA CHHHHHHHHHHHHHH | 10.09 | 30635358 | |
540 (in isoform 1) | Phosphorylation | - | 7.50 | 29899451 | |
542 | Phosphorylation | SCENTLNTLRYANRV HHHHHHHHHHHHHHC | 18.74 | 30635358 | |
545 (in isoform 1) | Phosphorylation | - | 16.02 | 25521595 | |
545 | Phosphorylation | NTLNTLRYANRVKEL HHHHHHHHHHHCEEE | 16.02 | 30635358 | |
547 (in isoform 1) | Phosphorylation | - | 40.10 | 22807455 | |
548 (in isoform 1) | Phosphorylation | - | 32.48 | 21183079 | |
550 (in isoform 1) | Phosphorylation | - | 43.71 | 20415495 | |
554 (in isoform 1) | Phosphorylation | - | 14.62 | 21183079 | |
556 (in isoform 1) | Phosphorylation | - | 20.95 | 20415495 | |
558 (in isoform 1) | Phosphorylation | - | 17.15 | 29899451 | |
571 | Phosphorylation | PIMHHPPSQIDDLET CCCCCCHHHCCCCHH | 44.19 | 15345747 | |
578 | Phosphorylation | SQIDDLETQWGVGSS HHCCCCHHCCCCCCC | 36.60 | 25367039 | |
584 | Phosphorylation | ETQWGVGSSPQRDDL HHCCCCCCCCCHHHH | 36.12 | 25338131 | |
585 | Phosphorylation | TQWGVGSSPQRDDLK HCCCCCCCCCHHHHH | 21.08 | 25521595 | |
679 | Acetylation | ILTELRDKVKSFRAA HHHHHHHHHHHHHHH | 45.16 | 23236377 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
186 | T | Phosphorylation | Kinase | PAK1 | Q13153 | PSP |
187 | T | Phosphorylation | Kinase | PAK1 | Q13153 | PSP |
245 | T | Phosphorylation | Kinase | MAP3K11 | Q16584 | GPS |
456 | S | Phosphorylation | Kinase | IKBKB | O14920 | GPS |
474 | T | Phosphorylation | Kinase | CDK5 | Q00535 | PSP |
479 | S | Phosphorylation | Kinase | PAK1 | Q13153 | PSP |
482 | T | Phosphorylation | Kinase | ROCK2 | O75116 | PSP |
488 | S | Phosphorylation | Kinase | PAK1 | Q13153 | PSP |
503 | S | Phosphorylation | Kinase | CDK5 | Q00535 | PSP |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KIF2A_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KIF2A_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
GMDS_HUMAN | GMDS | physical | 26496610 | |
ARHGH_HUMAN | ARHGEF17 | physical | 26496610 | |
KIF2C_HUMAN | KIF2C | physical | 26496610 | |
ORML1_HUMAN | ORMDL1 | physical | 26496610 | |
LARP4_HUMAN | LARP4 | physical | 26496610 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-571, PHOSPHORYLATION[LARGE SCALE ANALYSIS] AT SER-554 (ISOFORM 2), AND MASS SPECTROMETRY. |