KIF2A_MOUSE - dbPTM
KIF2A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIF2A_MOUSE
UniProt AC P28740
Protein Name Kinesin-like protein KIF2A
Gene Name Kif2a
Organism Mus musculus (Mouse).
Sequence Length 705
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, spindle. Lysosome . Localized to the spindle microtubules and spindle poles fro
Protein Description Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity)..
Protein Sequence MATANFGKIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPDEDIEPSPELPPPSSSSKVNKIVKNRRTVAAVKNDPPPRDNRVVGSARARPSQLPEQSSSAQQNGSVSDISPVQAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRAQDVDATNPNYEIMCMIRDFRGSLDYRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVNPAAAGDVHPIMHHPPSQIDDLETQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWIEDEKALLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDKVKSFRAALQEEEQASKQINPKRPRAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
75PhosphorylationPDEDIEPSPELPPPS
CCCCCCCCCCCCCCC
20.4425293948
82PhosphorylationSPELPPPSSSSKVNK
CCCCCCCCCCHHHHH
48.9326643407
83PhosphorylationPELPPPSSSSKVNKI
CCCCCCCCCHHHHHH
44.3926643407
84PhosphorylationELPPPSSSSKVNKIV
CCCCCCCCHHHHHHH
38.2226643407
85PhosphorylationLPPPSSSSKVNKIVK
CCCCCCCHHHHHHHH
42.4426643407
93 (in isoform 2)Phosphorylation-27.9829514104
96PhosphorylationKIVKNRRTVAAVKND
HHHHCCCCEEHHCCC
15.9727149854
99 (in isoform 2)Phosphorylation-14.4219367708
100 (in isoform 2)Phosphorylation-4.2527149854
101AcetylationRRTVAAVKNDPPPRD
CCCEEHHCCCCCCCC
51.4023806337
101 (in isoform 2)Phosphorylation-51.4029899451
126PhosphorylationPSQLPEQSSSAQQNG
HHHCCCCCCCCCCCC
25.2925619855
127PhosphorylationSQLPEQSSSAQQNGS
HHCCCCCCCCCCCCC
29.4125619855
128PhosphorylationQLPEQSSSAQQNGSV
HCCCCCCCCCCCCCH
35.0325619855
134PhosphorylationSSAQQNGSVSDISPV
CCCCCCCCHHHCCHH
26.4625619855
136PhosphorylationAQQNGSVSDISPVQA
CCCCCCHHHCCHHHH
30.8125619855
139PhosphorylationNGSVSDISPVQAAKK
CCCHHHCCHHHHHHH
24.8225521595
156PhosphorylationGPPSRRKSNCVKEVE
CCCCCCCCHHHHHHH
33.38-
206PhosphorylationMIRDFRGSLDYRPLT
EEECCCCCCCCCCCC
17.5129899451
213PhosphorylationSLDYRPLTTADPIDE
CCCCCCCCCCCCCCC
23.71-
214PhosphorylationLDYRPLTTADPIDEH
CCCCCCCCCCCCCCC
36.42-
246PhosphorylationMKDLDVITIPSKDVV
CCCCCEEEECCCCEE
27.04-
249PhosphorylationLDVITIPSKDVVMVH
CCEEEECCCCEEEEC
37.32-
272PhosphorylationTRYLENQTFRFDYAF
HHHHHCCEEEEEEEE
28.49-
282PhosphorylationFDYAFDDSAPNEMVY
EEEEECCCCCCCEEE
47.68-
327PhosphorylationHTMGGDFSGKNQDCS
EECCCCCCCCCCCHH
54.31-
466PhosphorylationGNERGADTSSADRQT
CCCCCCCCCCCHHHH
24.85-
467PhosphorylationNERGADTSSADRQTR
CCCCCCCCCCHHHHH
24.87-
468PhosphorylationERGADTSSADRQTRL
CCCCCCCCCHHHHHH
35.96-
483PhosphorylationEGAEINKSLLALKEC
CHHHHHHHHHHHHHH
24.9122006019
488UbiquitinationNKSLLALKECIRALG
HHHHHHHHHHHHHHC
44.95-
501PhosphorylationLGRNKPHTPFRASKL
HCCCCCCCCCHHHHH
32.42-
506PhosphorylationPHTPFRASKLTQVLR
CCCCCHHHHHHHHHH
24.76-
507UbiquitinationHTPFRASKLTQVLRD
CCCCHHHHHHHHHHH
55.35-
509PhosphorylationPFRASKLTQVLRDSF
CCHHHHHHHHHHHHC
21.99-
515PhosphorylationLTQVLRDSFIGENSR
HHHHHHHHCCCCCCC
16.60-
523PhosphorylationFIGENSRTCMIATIS
CCCCCCCEEEEEEEC
13.2730635358
528PhosphorylationSRTCMIATISPGMAS
CCEEEEEEECCCHHH
15.8630635358
528 (in isoform 1)Phosphorylation-15.8621183079
530PhosphorylationTCMIATISPGMASCE
EEEEEEECCCHHHHH
15.8530635358
530 (in isoform 1)Phosphorylation-15.8522807455
535 (in isoform 1)Phosphorylation-17.0529899451
535PhosphorylationTISPGMASCENTLNT
EECCCHHHHHHHHHH
17.0530635358
539PhosphorylationGMASCENTLNTLRYA
CHHHHHHHHHHHHHH
10.0930635358
540 (in isoform 1)Phosphorylation-7.5029899451
542PhosphorylationSCENTLNTLRYANRV
HHHHHHHHHHHHHHC
18.7430635358
545 (in isoform 1)Phosphorylation-16.0225521595
545PhosphorylationNTLNTLRYANRVKEL
HHHHHHHHHHHCEEE
16.0230635358
547 (in isoform 1)Phosphorylation-40.1022807455
548 (in isoform 1)Phosphorylation-32.4821183079
550 (in isoform 1)Phosphorylation-43.7120415495
554 (in isoform 1)Phosphorylation-14.6221183079
556 (in isoform 1)Phosphorylation-20.9520415495
558 (in isoform 1)Phosphorylation-17.1529899451
571PhosphorylationPIMHHPPSQIDDLET
CCCCCCHHHCCCCHH
44.1915345747
578PhosphorylationSQIDDLETQWGVGSS
HHCCCCHHCCCCCCC
36.6025367039
584PhosphorylationETQWGVGSSPQRDDL
HHCCCCCCCCCHHHH
36.1225338131
585PhosphorylationTQWGVGSSPQRDDLK
HCCCCCCCCCHHHHH
21.0825521595
679AcetylationILTELRDKVKSFRAA
HHHHHHHHHHHHHHH
45.1623236377

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
186TPhosphorylationKinasePAK1Q13153
PSP
187TPhosphorylationKinasePAK1Q13153
PSP
245TPhosphorylationKinaseMAP3K11Q16584
GPS
456SPhosphorylationKinaseIKBKBO14920
GPS
474TPhosphorylationKinaseCDK5Q00535
PSP
479SPhosphorylationKinasePAK1Q13153
PSP
482TPhosphorylationKinaseROCK2O75116
PSP
488SPhosphorylationKinasePAK1Q13153
PSP
503SPhosphorylationKinaseCDK5Q00535
PSP

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIF2A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIF2A_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GMDS_HUMANGMDSphysical
26496610
ARHGH_HUMANARHGEF17physical
26496610
KIF2C_HUMANKIF2Cphysical
26496610
ORML1_HUMANORMDL1physical
26496610
LARP4_HUMANLARP4physical
26496610

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIF2A_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-571, PHOSPHORYLATION[LARGE SCALE ANALYSIS] AT SER-554 (ISOFORM 2), AND MASS SPECTROMETRY.

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