OSBL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OSBL2_HUMAN
• UniProt AC: Q9H1P3
• Protein Name: Oxysterol-binding protein-related protein 2
• Gene Name: OSBPL2
• Organism: Homo sapiens (Human).
• Sequence Length: 480
• Protein Description: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. [PubMed: 11279184 Binds 25-hydroxycholesterol]
• Protein Sequence: MNGEEEFFDAVTGFDSDNSSGEFSEANQKVTGMIDLDTSKNNRIGKTGERPSQENGIQKHRTSLPAPMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKLFMIYGKWTECLWGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQVIPGSKLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQREARRERAKEEAEWQTRWFYPGNNPYTGTPDWLYAGDYFERNFSDCPDIY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	EEFFDAVTGFDSDNS HHHHHHHCCCCCCCC	33.57	27251275
16	Phosphorylation	DAVTGFDSDNSSGEF HHHCCCCCCCCCCCC	36.11	27251275
19	Phosphorylation	TGFDSDNSSGEFSEA CCCCCCCCCCCCCHH	44.72	27251275
20	Phosphorylation	GFDSDNSSGEFSEAN CCCCCCCCCCCCHHH	48.90	11735225
38	Phosphorylation	TGMIDLDTSKNNRIG ECEEECCCCCCCCCC	49.23	22199227
39	Phosphorylation	GMIDLDTSKNNRIGK CEEECCCCCCCCCCC	32.81	21815630
47	Phosphorylation	KNNRIGKTGERPSQE CCCCCCCCCCCCCHH	38.78	-
52	Phosphorylation	GKTGERPSQENGIQK CCCCCCCCHHCCCCC	57.24	25159151
59	Ubiquitination	SQENGIQKHRTSLPA CHHCCCCCCCCCCCC	32.88	-
62	Phosphorylation	NGIQKHRTSLPAPMF CCCCCCCCCCCCCCC	34.04	28348404
63	Phosphorylation	GIQKHRTSLPAPMFS CCCCCCCCCCCCCCC	32.10	24719451
81	Ubiquitination	FSVWTILKKCVGLEL HHHHHHHHHHHCCCH	40.03	-
138 (in isoform 2)	Ubiquitination	-	2.81	21890473
150 (in isoform 1)	Ubiquitination	-	45.91	21890473
150	Ubiquitination	SQWERTGKPFNPLLG HHHHHHCCCCCHHHH	45.91	21906983
160	Phosphorylation	NPLLGETYELIREDL CHHHHHHHHHHHHHC	12.39	27642862
197 (in isoform 2)	Ubiquitination	-	31.10	21890473
209	Ubiquitination	PKLKFWGKSVEAEPR CCCCCCEECCEECCC	41.76	21890473
209 (in isoform 1)	Ubiquitination	-	41.76	21890473
282	Ubiquitination	LFGKELHKVEGHIQD CCCHHHHHEECEEEC	55.39	-
349 (in isoform 2)	Ubiquitination	-	9.61	21890473
361	Ubiquitination	VQVIPGSKLLWRINT EEECCCCEEEEEEEC	54.22	2190698
361 (in isoform 1)	Ubiquitination	-	54.22	21890473
411 (in isoform 2)	Ubiquitination	-	2.31	-
423	Ubiquitination	MDLASQEKERLEEKQ CCHHHHHHHHHHHHH	40.26	-
439	Ubiquitination	EARRERAKEEAEWQT HHHHHHHHHHHHHCC	63.41	-
474	Phosphorylation	DYFERNFSDCPDIY- CHHHHCCCCCCCCC-	41.68	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OSBL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OSBL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OSBL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZFPL1_HUMAN	ZFPL1	physical	28514442
BIRC6_HUMAN	BIRC6	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• 616340: Deafness, autosomal dominant, 67 (DFNA67)
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.