STXB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STXB2_MOUSE
• UniProt AC: Q64324
• Protein Name: Syntaxin-binding protein 2
• Gene Name: Stxbp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 593
• Protein Description: Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity)..
• Protein Sequence: MAPLGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIADFQGTPTFTYKAAHIFFTDTCPEPLFSELGRSRLAKAVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAGERGRQLDALAQQIATLCATLQEYPSIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTYRYETTGLSESREKAVLLDEDDDLWVELRHMHIADVSKKVTELLKTFCESKRLTTDKANIKDLSHILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCSVEQDLAMGSDAEGEKIKDAMKLIVPVLLDASVPPYDKIRVLLLYILLRNGVSEENLAKLIQHANVQSYSSLIRNLEQLGGTVTNSAGSGTSSRLERRERMEPTYQLSRWSPVIKDVMEDVVEDRLDRKLWPFVSDPAPVPSSQAAVSARFGHWHKNKAGVEARAGPRLIVYIVGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKTLDQKLEGVALP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	LKAVVGEKILSGVIR CHHHHHHHHHHHHHH	42.91	-
37	Phosphorylation	VLIMDHPSMRILSSC EEEECCCHHHHHHHH	19.78	22817900
70	Phosphorylation	KRREPIPSLEAIYLL HCCCCCCCCEEEEEC	39.29	-
94	Phosphorylation	LIADFQGTPTFTYKA HHHHHCCCCCEEEEE	14.36	26745281
96	Phosphorylation	ADFQGTPTFTYKAAH HHHCCCCCEEEEEEE	28.57	26745281
193	Ubiquitination	YPSIRYRKGPEDTAQ CCCCCCCCCHHHHHH	70.64	-
228	Phosphorylation	EGPEKTRSQLLIMDR CCCCCHHHHEEEEEC	30.34	22817900
324	Ubiquitination	TTDKANIKDLSHILK CCCCCCHHHHHHHHH	53.04	-
327	Phosphorylation	KANIKDLSHILKKMP CCCHHHHHHHHHHCH	20.72	27180971
360	Phosphorylation	CMKHFKGSVEKLCSV HHHHHCHHHHHHHCH	27.91	29472430
366	Phosphorylation	GSVEKLCSVEQDLAM HHHHHHHCHHHHHCC	38.84	21189417
447	Phosphorylation	NLEQLGGTVTNSAGS HHHHHCCEEECCCCC	23.51	29472430
449	Phosphorylation	EQLGGTVTNSAGSGT HHHCCEEECCCCCCC	24.24	29472430
451	Phosphorylation	LGGTVTNSAGSGTSS HCCEEECCCCCCCCH	25.33	29472430
454	Phosphorylation	TVTNSAGSGTSSRLE EEECCCCCCCCHHHH	38.32	29472430
456	Phosphorylation	TNSAGSGTSSRLERR ECCCCCCCCHHHHHH	25.81	24719451
457	Phosphorylation	NSAGSGTSSRLERRE CCCCCCCCHHHHHHH	19.58	29472430
458	Phosphorylation	SAGSGTSSRLERRER CCCCCCCHHHHHHHH	40.50	29472430
494	Ubiquitination	VEDRLDRKLWPFVSD HHHCHHHCCCCCCCC	55.35	-
545	Phosphorylation	IVGGVAMSEMRAAYE EECCHHHHHHHHHHH	20.64	23140645
581	Ubiquitination	TRFLDDLKTLDQKLE HHHHHHHHHHHHHHC	54.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STXB2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STXB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STXB2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STXB2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.