| UniProt ID | CDN2A_MOUSE | |
|---|---|---|
| UniProt AC | P51480 | |
| Protein Name | Cyclin-dependent kinase inhibitor 2A {ECO:0000312|MGI:MGI:104738} | |
| Gene Name | Cdkn2a {ECO:0000312|MGI:MGI:104738} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 168 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.. | |
| Protein Sequence | MESAADRLARAAAQGRVHDVRALLEAGVSPNAPNSFGRTPIQVMMMGNVHVAALLLNYGADSNCEDPTTFSRPVHDAAREGFLDTLVVLHGSGARLDVRDAWGRLPLDLAQERGHQDIVRYLRSAGCSLCSAGWSLCTAGNVAQTDGHSFSSSTPRALELRGQSQEQS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 121 (in isoform 2) | Phosphorylation | - | 22942356 | ||
| 125 (in isoform 2) | Phosphorylation | - | 20415495 | ||
| 152 | Phosphorylation | TDGHSFSSSTPRALE CCCCCCCCCCCHHHH | - | ||
| 164 | Phosphorylation | ALELRGQSQEQS--- HHHHCCCCCCCC--- | 22942356 | ||
| 168 | Phosphorylation | RGQSQEQS------- CCCCCCCC------- | 20415495 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CDN2A_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDN2A_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDN2A_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TBRG1_MOUSE | Tbrg1 | physical | 17110379 | |
| SP1_MOUSE | Sp1 | physical | 21555589 | |
| MDM2_MOUSE | Mdm2 | physical | 10713175 | |
| RL9_MOUSE | Rpl9 | physical | 16582619 | |
| RS7_MOUSE | Rps7 | physical | 16582619 | |
| HS90B_MOUSE | Hsp90ab1 | physical | 16582619 | |
| ERF3A_MOUSE | Gspt1 | physical | 16582619 | |
| TBRG1_MOUSE | Tbrg1 | physical | 16582619 | |
| RABL6_MOUSE | Rabl6 | physical | 16582619 | |
| PEX19_MOUSE | Pex19 | physical | 16582619 | |
| NEB2_MOUSE | Ppp1r9b | physical | 16582619 | |
| OSTP_MOUSE | Spp1 | physical | 16582619 | |
| ZFP91_MOUSE | Zfp91 | physical | 16582619 | |
| TBA1A_MOUSE | Tuba1a | physical | 16582619 | |
| TPIS_MOUSE | Tpi1 | physical | 16582619 | |
| EIF3A_MOUSE | Eif3a | physical | 16582619 | |
| PEX19_HUMAN | PEX19 | physical | 12581788 | |
| CARF_HUMAN | CDKN2AIP | physical | 12581788 | |
| PEX19_HUMAN | PEX19 | physical | 12154087 | |
| NPM_MOUSE | Npm1 | physical | 15485902 | |
| MDM2_MOUSE | Mdm2 | physical | 15485902 | |
| MDM2_MOUSE | Mdm2 | physical | 23580573 | |
| MYC_MOUSE | Myc | physical | 15361884 | |
| P53_MOUSE | Trp53 | physical | 9653180 | |
| CARF_HUMAN | CDKN2AIP | physical | 12154087 | |
| CARF_MOUSE | Cdkn2aip | physical | 12154087 | |
| ZN235_MOUSE | Zfp93 | physical | 16582619 | |
| MDM2_MOUSE | Mdm2 | physical | 22378045 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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