RABL6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RABL6_MOUSE
• UniProt AC: Q5U3K5
• Protein Name: Rab-like protein 6
• Gene Name: Rabl6
• Organism: Mus musculus (Mouse).
• Sequence Length: 725
• Subcellular Localization: Nucleus . Cytoplasm . Predominantly cytoplasmic.
• Protein Description: May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A (By similarity)..
• Protein Sequence: MFSALKKLVGSEQAPGRDKNIPAGLQSMNQALQRRFAKGVQYNMKIVIRGDRNTGKTALWHRLQGKKFVEEYIPTQEIQVTSIHWNYKTTDDVVKVEVWDVVDKGKCKKRGDGLKTENDPQEAESELALDAEFLDVYKNCNGVVMMFDITKQWTFNYVLRELPKVPTHVPVCVLGNYRDMGEHRVILPDDVRDFIEHLDRPPGSSYFRYAESSMKNSFGLKYLHKFFNIPFLQLQRETLLRQLETNQLDIDATLEELSVQQETEDQNYSIFLEMMEARSRGHASPLAANGQSPSSGSQSPVVPPSAVSTGSSSPSTPQPAPQLSLGVSSTCPSAPSPVPSLEAMPSSVHSSAPAPTPAPAPAPAQRRSIISRLFGTSPAAEVTPSPPEPAPALEAPARVQNVEDFVPEDGLDRSFLEDTSVPKDKKVGAKGPQQDSDSDDGEALGGNPMVAGFQDDVDIEDQTHGKSLLPSDPMPSKNISLSSEEEAEGLAGHPRVAPQQCSEPETKWSSTKVSHPQKKRAPTRGTPPWSDGLTTDDSERPQEGKDKQVSSESDPEGPIAAQMLSFVMDDPDFESDESDTQRRMGRFPVREDLSDVTDEDTGPAQPPPPSKLPGAFRLKNDSDLFGLGLEEMGPKESSDEDRDSKLPSKEKKKKKKKSKEEEEKTTKKKSKHKKSKDKEEGKEDRKKKRKPPRSKEQKAADELEAFLGGGAPGSRHPGGGDYEEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MFSALKKL -------CCHHHHHH		-
11	Phosphorylation	ALKKLVGSEQAPGRD HHHHHHCCCCCCCCC		22817900
368	Phosphorylation	PAPAQRRSIISRLFG CCHHHHHHHHHHHHC		24719451
371	Phosphorylation	AQRRSIISRLFGTSP HHHHHHHHHHHCCCC		24719451
376	Phosphorylation	IISRLFGTSPAAEVT HHHHHHCCCCCCCCC		26824392
377	Phosphorylation	ISRLFGTSPAAEVTP HHHHHCCCCCCCCCC		22942356
383	Phosphorylation	TSPAAEVTPSPPEPA CCCCCCCCCCCCCCC		25619855
385	Phosphorylation	PAAEVTPSPPEPAPA CCCCCCCCCCCCCCC		26824392
414	Phosphorylation	PEDGLDRSFLEDTSV CCCCCCHHHHCCCCC		26824392
419	Phosphorylation	DRSFLEDTSVPKDKK CHHHHCCCCCCCCCC		23984901
420	Phosphorylation	RSFLEDTSVPKDKKV HHHHCCCCCCCCCCC		23984901
436	Phosphorylation	AKGPQQDSDSDDGEA CCCCCCCCCCCCCHH		24925903
438	Phosphorylation	GPQQDSDSDDGEALG CCCCCCCCCCCHHCC		24925903
476	Phosphorylation	LPSDPMPSKNISLSS CCCCCCCCCCCCCCC		22817900
480	Phosphorylation	PMPSKNISLSSEEEA CCCCCCCCCCCHHHH		18388127
482	Phosphorylation	PSKNISLSSEEEAEG CCCCCCCCCHHHHHH		18388127
483	Phosphorylation	SKNISLSSEEEAEGL CCCCCCCCHHHHHHH		18388127
501	S-nitrosocysteine	PRVAPQQCSEPETKW CCCCCCCCCCCCCCC		-
502	Phosphorylation	RVAPQQCSEPETKWS CCCCCCCCCCCCCCC		25521595
506	Phosphorylation	QQCSEPETKWSSTKV CCCCCCCCCCCCCCC		25159016
523	Phosphorylation	PQKKRAPTRGTPPWS CCCCCCCCCCCCCCC		26643407
526	Phosphorylation	KRAPTRGTPPWSDGL CCCCCCCCCCCCCCC		22802335
530	Phosphorylation	TRGTPPWSDGLTTDD CCCCCCCCCCCCCCC		25338131
535	Phosphorylation	PWSDGLTTDDSERPQ CCCCCCCCCCCCCCC		25367039
538	Phosphorylation	DGLTTDDSERPQEGK CCCCCCCCCCCCCCC		20469934
575	Phosphorylation	MDDPDFESDESDTQR CCCCCCCCCCHHHHH		25338131
578	Phosphorylation	PDFESDESDTQRRMG CCCCCCCHHHHHHHC		29899451
580	Phosphorylation	FESDESDTQRRMGRF CCCCCHHHHHHHCCC		29899451
594	Phosphorylation	FPVREDLSDVTDEDT CCCCCCCCCCCCCCC		25521595
597	Phosphorylation	REDLSDVTDEDTGPA CCCCCCCCCCCCCCC		25521595
601	Phosphorylation	SDVTDEDTGPAQPPP CCCCCCCCCCCCCCC		25521595
610	Phosphorylation	PAQPPPPSKLPGAFR CCCCCCCCCCCCCEE		25159016
622	Phosphorylation	AFRLKNDSDLFGLGL CEECCCCHHCCCCCH		24925903
637	Phosphorylation	EEMGPKESSDEDRDS HHCCCCCCCCCHHHC		24925903
638	Phosphorylation	EMGPKESSDEDRDSK HCCCCCCCCCHHHCC		24925903
644	Phosphorylation	SSDEDRDSKLPSKEK CCCCHHHCCCCCHHH		24925903
648	Phosphorylation	DRDSKLPSKEKKKKK HHHCCCCCHHHHHHH		24719451
694	Phosphorylation	KKRKPPRSKEQKAAD HHCCCCCHHHHHHHH		22817900
722	Phosphorylation	RHPGGGDYEEL---- CCCCCCCCCCC----		26026062

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RABL6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RABL6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RABL6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDN2A_MOUSE	Cdkn2a	physical	16582619
ARF_MOUSE	Cdkn2a	physical	16582619

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.