dbPTM

ZFP91_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZFP91_MOUSE
UniProt AC	Q62511
Protein Name	E3 ubiquitin-protein ligase ZFP91
Gene Name	Zfp91
Organism	Mus musculus (Mouse).
Sequence Length	572
Subcellular Localization	Nucleus .
Protein Description	Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis..
Protein Sequence	MPGETEEPRSPEQQDQEGGPAAAADAASEELRPGAAAAPAAPAETASSRVLRGGRDRGRTAAAAAAAAAAVSRRRKAEYPRRRRSSPSNRPPDGPGHQPAAAKPPSPAQGKKSPRLQCIEKLTTDKDPKEEKEDDSVLPQEVSITTTRASRSWRSSSRTSISRLRDSENTRSSRSKTGSLQLVCKTEPITDQLDYDVPEEHQSPGGISSDEEEEEEEEMLISEEEIPFKDDPRDETYKPHLERETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEENEIREDEEPPRKRGRRRKDDKSPRLPKRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKYQHLLKKKYVCPHPSCGRLFRLQKQLLRHAKHHTDQRDYICEYCARAFKSSHNLAVHRMIHTGEKPLQCEICGFTCRQKASLNWHMKKHDADSFYQFSCNICGKKFEKKDSVVAHKAKSHPEVLIAEALAANAGALITSTDILGTNPEPLTQPADGQGLPLLPEPLGNSTAGECLLLEAEGMSKSYCSGTERVSLMADGKIFVGSGSSGGTEGLVMNSDILGATTEVLIEDTDSTGP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MPGETEEPRSPE ---CCCCCCCCCCHH	52.11	25619855
10	Phosphorylation	GETEEPRSPEQQDQE CCCCCCCCHHHHCCC	43.43	21082442
28	Phosphorylation	AAAADAASEELRPGA CHHHHHHCHHCCCCC	33.07	25619855
45	Phosphorylation	APAAPAETASSRVLR CCCCCCHHHHHHHHC	33.67	25619855
47	Phosphorylation	AAPAETASSRVLRGG CCCCHHHHHHHHCCC	26.54	25619855
48	Phosphorylation	APAETASSRVLRGGR CCCHHHHHHHHCCCC	24.76	25619855
72	Phosphorylation	AAAAAAVSRRRKAEY HHHHHHHHHHHHCCC	18.49	27149854
79	Phosphorylation	SRRRKAEYPRRRRSS HHHHHCCCCCCCCCC	13.60	20139300
85	Phosphorylation	EYPRRRRSSPSNRPP CCCCCCCCCCCCCCC	44.80	23684622
86	Phosphorylation	YPRRRRSSPSNRPPD CCCCCCCCCCCCCCC	30.45	23684622
88	Phosphorylation	RRRRSSPSNRPPDGP CCCCCCCCCCCCCCC	47.63	23684622
106	Phosphorylation	PAAAKPPSPAQGKKS CCCCCCCCCCCCCCC	41.20	23684622
113	Phosphorylation	SPAQGKKSPRLQCIE CCCCCCCCCCHHHHH	20.81	27717184
146	Phosphorylation	PQEVSITTTRASRSW CCEEEEEEECCCHHH	16.77	22807455
156	Phosphorylation	ASRSWRSSSRTSISR CCHHHHCCCCCCHHH	18.44	25266776
157	Phosphorylation	SRSWRSSSRTSISRL CHHHHCCCCCCHHHH	40.60	29514104
159	Phosphorylation	SWRSSSRTSISRLRD HHHCCCCCCHHHHHC	32.15	19367708
160	Phosphorylation	WRSSSRTSISRLRDS HHCCCCCCHHHHHCC	19.91	19367708
167	Phosphorylation	SISRLRDSENTRSSR CHHHHHCCCCCCCCC	26.72	-
170	Phosphorylation	RLRDSENTRSSRSKT HHHCCCCCCCCCCCC	28.07	-
172	Phosphorylation	RDSENTRSSRSKTGS HCCCCCCCCCCCCCC	28.23	-
173	Phosphorylation	DSENTRSSRSKTGSL CCCCCCCCCCCCCCE	36.96	-
179	Phosphorylation	SSRSKTGSLQLVCKT CCCCCCCCEEEEEEC	20.41	29514104
252	Phosphorylation	TPKPRRKSGKVKEEK CCCCCCCCCCCCCHH	41.87	20139300
298	Phosphorylation	RRRKDDKSPRLPKRR CCCCCCCCCCCCCCC	23.42	-
322	Phosphorylation	CEMEGCGTVLAHPRY EECCCCCCCCCCHHH	19.20	-
369	Phosphorylation	LRHAKHHTDQRDYIC HHHHHCCCCCHHHHH	33.28	-
397	Phosphorylation	AVHRMIHTGEKPLQC EHHEEECCCCCCEEE	35.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZFP91_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZFP91_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZFP91_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CDN2A_MOUSE	Cdkn2a	physical	16582619
ARF_MOUSE	Cdkn2a	physical	16582619

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZFP91_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, AND MASSSPECTROMETRY.	17242355 [Abstract]