ERF3A_MOUSE - dbPTM
ERF3A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ERF3A_MOUSE
UniProt AC Q8R050
Protein Name Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Gene Name Gspt1
Organism Mus musculus (Mouse).
Sequence Length 636
Subcellular Localization
Protein Description Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity)..
Protein Sequence MDPSSGGGGGGGGGGSSSSSDSAPDCWDQTDMEAPGPGPCGGGGSGSGSMAAVAEAQRENLSAAFSRQLNVNAKPFVPNVHAAEFVPSFLRGPAQPPLSPAGAAGGDHGAGSGAGGPSEPVESSQDQSCEGSNSTVSMELSEPVVENGETEMSPEESWEHKEEISEAEPGGGSSGDGRPPEESTQEMMEEEEEIPKPKSAVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDSVAPGENLKIRLKGIEEEEILPGFILCDLNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
74UbiquitinationRQLNVNAKPFVPNVH
HHCCCCCCCCCCCCH		33.51-
74AcetylationRQLNVNAKPFVPNVH
HHCCCCCCCCCCCCH		33.5123806337
165PhosphorylationWEHKEEISEAEPGGG
HCCHHHHCCCCCCCC		33.7528973931
173PhosphorylationEAEPGGGSSGDGRPP
CCCCCCCCCCCCCCC		34.1325521595
174PhosphorylationAEPGGGSSGDGRPPE
CCCCCCCCCCCCCCH		44.1525521595
199PhosphorylationEEIPKPKSAVAPPGA
HCCCCCCCCCCCCCC		36.1823684622
225PhosphorylationGHVDAGKSTIGGQIM
EECCCCCCCHHHHHH		25.0828576409
226PhosphorylationHVDAGKSTIGGQIMY
ECCCCCCCHHHHHHH		27.4228576409
233PhosphorylationTIGGQIMYLTGMVDK
CHHHHHHHHCCCCCH		11.6228576409
235PhosphorylationGGQIMYLTGMVDKRT
HHHHHHHCCCCCHHH		13.0228576409
245MalonylationVDKRTLEKYEREAKE
CCHHHHHHHHHHHHH		56.3726320211
333UbiquitinationEFETGFEKGGQTREH
CCCCCCCCCCCCHHH		67.1122790023
333MalonylationEFETGFEKGGQTREH
CCCCCCCCCCCCHHH		67.1126320211
333UbiquitinationEFETGFEKGGQTREH
CCCCCCCCCCCCHHH		67.1122790023
345MalonylationREHAMLAKTAGVKHL
HHHHHHHHHHCCCEE		34.6426320211
350AcetylationLAKTAGVKHLIVLIN
HHHHHCCCEEEEEEE		31.6022826441
363PhosphorylationINKMDDPTVNWSNER
EECCCCCCCCCCCHH		33.2028576409
371PhosphorylationVNWSNERYEECKEKL
CCCCCHHHHHHHHHH		15.2018779572
377UbiquitinationRYEECKEKLVPFLKK
HHHHHHHHHHHHHHH		40.0422790023
377UbiquitinationRYEECKEKLVPFLKK
HHHHHHHHHHHHHHH		40.0422790023
384MalonylationKLVPFLKKVGFNPKK
HHHHHHHHCCCCCCC		50.1426320211
390MalonylationKKVGFNPKKDIHFMP
HHCCCCCCCCEEEEE		65.2726073543
391MalonylationKVGFNPKKDIHFMPC
HCCCCCCCCEEEEEC		64.2726320211
391UbiquitinationKVGFNPKKDIHFMPC
HCCCCCCCCEEEEEC		64.2722790023
391AcetylationKVGFNPKKDIHFMPC
HCCCCCCCCEEEEEC		64.2722826441
391UbiquitinationKVGFNPKKDIHFMPC
HCCCCCCCCEEEEEC		64.27-
398GlutathionylationKDIHFMPCSGLTGAN
CCEEEEECCCCCCCC		3.1924333276
434PhosphorylationNLPNFNRSVDGPIRL
CCCCCCCCCCCCCCC		26.1829514104
457AcetylationMGTVVLGKLESGSIC
CCEEEEEECCCCCCC		44.9422826441
460PhosphorylationVVLGKLESGSICKGQ
EEEEECCCCCCCCCC		48.5618779572
464GlutathionylationKLESGSICKGQQLVM
ECCCCCCCCCCEEEE		4.3124333276
464S-palmitoylationKLESGSICKGQQLVM
ECCCCCCCCCCEEEE		4.3128526873
465UbiquitinationLESGSICKGQQLVMM
CCCCCCCCCCEEEEC		59.0722790023
465UbiquitinationLESGSICKGQQLVMM
CCCCCCCCCCEEEEC		59.0722790023
485PhosphorylationVEVLGILSDDVETDS
EEEEEEEECCCCCCC		29.8226525534
490PhosphorylationILSDDVETDSVAPGE
EEECCCCCCCCCCCC		33.1626525534
518GlutathionylationILPGFILCDLNNLCH
CCCCEEEEECCCCCC		4.8424333276
524GlutathionylationLCDLNNLCHSGRTFD
EEECCCCCCCCCCCC		2.3324333276
572UbiquitinationLICLVDKKSGEKSKT
EEEEEECCCCCCCCC		60.26-
585MalonylationKTRPRFVKQDQVCIA
CCCCCCCCHHHHHHH		45.5026320211
590S-palmitoylationFVKQDQVCIARLRTA
CCCHHHHHHHHHHCC		1.3526165157
590GlutathionylationFVKQDQVCIARLRTA
CCCHHHHHHHHHHCC		1.3524333276
590S-nitrosocysteineFVKQDQVCIARLRTA
CCCHHHHHHHHHHCC		1.35-
627MalonylationGKTIAIGKVLKLVPE
CCEEEEEEEEEECCC		37.9826320211
630MalonylationIAIGKVLKLVPEKD-
EEEEEEEEECCCCC-		50.8826320211
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ERF3A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ERF3A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ERF3A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDN2A_MOUSECdkn2aphysical
16582619
ARF_MOUSECdkn2aphysical
16582619
CSPG4_HUMANCSPG4physical
26496610
IF4G1_HUMANEIF4G1physical
26496610
ERCC3_HUMANERCC3physical
26496610
ERF1_HUMANETF1physical
26496610
HMGA1_HUMANHMGA1physical
26496610
NPAT_HUMANNPATphysical
26496610
NTH_HUMANNTHL1physical
26496610
P4HA1_HUMANP4HA1physical
26496610
PFD5_HUMANPFDN5physical
26496610
EIF3I_HUMANEIF3Iphysical
26496610
PABP4_HUMANPABPC4physical
26496610
GTPB1_HUMANGTPBP1physical
26496610
BZW1_HUMANBZW1physical
26496610
IASPP_HUMANPPP1R13Lphysical
26496610
LAR4B_HUMANLARP4Bphysical
26496610
ADNP_HUMANADNPphysical
26496610
PABP1_HUMANPABPC1physical
26496610
ZBT11_HUMANZBTB11physical
26496610
RM27_HUMANMRPL27physical
26496610
GOLM1_HUMANGOLM1physical
26496610
RTCB_HUMANRTCBphysical
26496610
CN166_HUMANC14orf166physical
26496610
WDR74_HUMANWDR74physical
26496610
CHSTC_HUMANCHST12physical
26496610
PLXA3_HUMANPLXNA3physical
26496610
PNO1_HUMANPNO1physical
26496610
SHRM3_HUMANSHROOM3physical
26496610
SELB_HUMANEEFSECphysical
26496610
TTC31_HUMANTTC31physical
26496610
CCD86_HUMANCCDC86physical
26496610
TBL1R_HUMANTBL1XR1physical
26496610
ASCC2_HUMANASCC2physical
26496610
RBM45_HUMANRBM45physical
26496610
HSC20_HUMANHSCBphysical
26496610
MAP12_HUMANMETAP1Dphysical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ERF3A_MOUSE

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Related Literatures of Post-Translational Modification

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