SELB_HUMAN - dbPTM
SELB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SELB_HUMAN
UniProt AC P57772
Protein Name Selenocysteine-specific elongation factor
Gene Name EEFSEC
Organism Homo sapiens (Human).
Sequence Length 596
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP..
Protein Sequence MAGRRVNVNVGVLGHIDSGKTALARALSTTASTAAFDKQPQSRERGITLDLGFSCFSVPLPARLRSSLPEFQAAPEAEPEPGEPLLQVTLVDCPGHASLIRTIIGGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAPIIPVAAKPGGPEAPETEAPQGIPELIELLTSQISIPTRDPSGPFLMSVDHCFSIKGQGTVMTGTILSGSISLGDSVEIPALKVVKKVKSMQMFHMPITSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVGHETVMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGILLHGLEDRNYADSFLPRLKVYKLKHKHGLVERAMDDYSVIGRSLFKKETNIQLFVGLKVHLSTGELGIIDSAFGQSGKFKIHIPGGLSPESKKILTPALKKRARAGRGEATRQEESAERSEPSQHVVLSLTFKRYVFDTHKRMVQSP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28PhosphorylationTALARALSTTASTAA
HHHHHHHHHHHCHHH		23.7925884760
29PhosphorylationALARALSTTASTAAF
HHHHHHHHHHCHHHH		27.5124719451
30PhosphorylationLARALSTTASTAAFD
HHHHHHHHHCHHHHC		18.4222817900
32PhosphorylationRALSTTASTAAFDKQ
HHHHHHHCHHHHCCC		19.2530622161
33PhosphorylationALSTTASTAAFDKQP
HHHHHHCHHHHCCCC		21.3830622161
38UbiquitinationASTAAFDKQPQSRER
HCHHHHCCCCCCCCC		58.38-
38AcetylationASTAAFDKQPQSRER
HCHHHHCCCCCCCCC		58.3825953088
84UbiquitinationAEPEPGEPLLQVTLV
CCCCCCCCCEEEEEE		44.2627667366
95UbiquitinationVTLVDCPGHASLIRT
EEEEECCCCHHHHHH		35.0127667366
155AcetylationIDLLPEGKRQAAIDK
HCCCCCHHHHHHHHH		39.4125953088
155UbiquitinationIDLLPEGKRQAAIDK
HCCCCCHHHHHHHHH		39.4127667366
162AcetylationKRQAAIDKMTKKMQK
HHHHHHHHHHHHHHH		42.2125953088
166UbiquitinationAIDKMTKKMQKTLEN
HHHHHHHHHHHHHHH		37.08-
169AcetylationKMTKKMQKTLENTKF
HHHHHHHHHHHHCCC		52.1325953088
175UbiquitinationQKTLENTKFRGAPII
HHHHHHCCCCCCCEE		44.65-
296UbiquitinationCVTQFDPKLLERGLV
EEEECCHHHHHCCCE		68.50-
332UbiquitinationFRGPLQTKAKFHITV
CCCCCCCCEEEEEEE		36.3029967540
334AcetylationGPLQTKAKFHITVGH
CCCCCCEEEEEEECC		38.7426051181
385PhosphorylationQYLSKDLTPAVTDND
HHHCCCCCCCCCCCH		21.2420068231
389PhosphorylationKDLTPAVTDNDEADK
CCCCCCCCCCHHHHH		31.0629514088
396AcetylationTDNDEADKKAGQATE
CCCHHHHHHHCCCCC		52.1226051181
418UbiquitinationWALVEFEKPVTCPRL
EEEEEECCCCCCCEE		50.54-
483SulfoxidationHGLVERAMDDYSVIG
CCCHHHHHCCCHHHC		5.1630846556
486PhosphorylationVERAMDDYSVIGRSL
HHHHHCCCHHHCHHH		10.6927642862
487PhosphorylationERAMDDYSVIGRSLF
HHHHCCCHHHCHHHC		17.7928857561
492PhosphorylationDYSVIGRSLFKKETN
CCHHHCHHHCCCCCC		32.7024719451
498PhosphorylationRSLFKKETNIQLFVG
HHHCCCCCCEEEEEE		46.64-
511PhosphorylationVGLKVHLSTGELGII
EEEEEEECCCCEEEE		21.35-
512PhosphorylationGLKVHLSTGELGIID
EEEEEECCCCEEEEE		40.82-
527UbiquitinationSAFGQSGKFKIHIPG
CCCCCCCEEEEECCC		49.0529967540
527AcetylationSAFGQSGKFKIHIPG
CCCCCCCEEEEECCC		49.0525953088
529UbiquitinationFGQSGKFKIHIPGGL
CCCCCEEEEECCCCC		36.5429967540
537PhosphorylationIHIPGGLSPESKKIL
EECCCCCCHHHHHHC		29.8730266825
540PhosphorylationPGGLSPESKKILTPA
CCCCCHHHHHHCCHH		42.5030266825
542UbiquitinationGLSPESKKILTPALK
CCCHHHHHHCCHHHH		52.8329967540
545PhosphorylationPESKKILTPALKKRA
HHHHHHCCHHHHHHH		15.2521815630
549MalonylationKILTPALKKRARAGR
HHCCHHHHHHHHCCC		42.1726320211
549UbiquitinationKILTPALKKRARAGR
HHCCHHHHHHHHCCC		42.1729967540
556MethylationKKRARAGRGEATRQE
HHHHHCCCCCCCHHH		38.50-
561MethylationAGRGEATRQEESAER
CCCCCCCHHHHHHHH		49.30-
582MethylationVVLSLTFKRYVFDTH
EEEEEEEEEEHHHHH		37.27-
590UbiquitinationRYVFDTHKRMVQSP-
EEHHHHHHHHHCCC-		44.2629967540
595PhosphorylationTHKRMVQSP------
HHHHHHCCC------		22.5922210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SELB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SELB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SELB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRPT1_HUMANTRPT1physical
22939629
U5S1_HUMANEFTUD2physical
26344197
RPB1_HUMANPOLR2Aphysical
26344197
RS3_HUMANRPS3physical
26344197
AP2A_HUMANTFAP2Aphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SELB_HUMAN

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Related Literatures of Post-Translational Modification

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