dbPTM

HSC20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HSC20_HUMAN
UniProt AC	Q8IWL3
Protein Name	Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
Gene Name	HSCB
Organism	Homo sapiens (Human).
Sequence Length	235
Subcellular Localization	Cytoplasm . Mitochondrion .
Protein Description	Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria..
Protein Sequence	MWRGRAGALLRVWGFWPTGVPRRRPLSCDAASQAGSNYPRCWNCGGPWGPGREDRFFCPQCRALQAPDPTRDYFSLMDCNRSFRVDTAKLQHRYQQLQRLVHPDFFSQRSQTEKDFSEKHSTLVNDAYKTLLAPLSRGLYLLKLHGIEIPERTDYEMDRQFLIEIMEINEKLAEAESEAAMKEIESIVKAKQKEFTDNVSSAFEQDDFEEAKEILTKMRYFSNIEEKIKLKKIPL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	VPRRRPLSCDAASQA CCCCCCCCCCHHHHC	16.78	28555341
82	Phosphorylation	SLMDCNRSFRVDTAK HHHCCCCCCCCCHHH	11.92	-
87	Phosphorylation	NRSFRVDTAKLQHRY CCCCCCCHHHHHHHH	23.88	-
94	Phosphorylation	TAKLQHRYQQLQRLV HHHHHHHHHHHHHHH	9.85	24719451
107	Phosphorylation	LVHPDFFSQRSQTEK HHCHHHHCCCCCCCH	25.36	24719451
119	Ubiquitination	TEKDFSEKHSTLVND CCHHHHHHHHHHHHH	41.48	-
128	Nitration	STLVNDAYKTLLAPL HHHHHHHHHHHHHHH	13.84	-
193	Ubiquitination	SIVKAKQKEFTDNVS HHHHHHHHHHCCCHH	54.83	-
201	Phosphorylation	EFTDNVSSAFEQDDF HHCCCHHHHHCCCCH	32.47	-
212	Ubiquitination	QDDFEEAKEILTKMR CCCHHHHHHHHHHHH	48.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HSC20_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HSC20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HSC20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ISCU_HUMAN	ISCU	physical	24573684

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HSC20_HUMAN

Related Literatures of Post-Translational Modification