| UniProt ID | NTH_HUMAN | |
|---|---|---|
| UniProt AC | P78549 | |
| Protein Name | Endonuclease III-like protein 1 {ECO:0000255|HAMAP-Rule:MF_03183} | |
| Gene Name | NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 312 | |
| Subcellular Localization | Nucleus . Mitochondrion . | |
| Protein Description | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.. | |
| Protein Sequence | MCSPQESGMTALSARMLTRSRSLGPGAGPRGCREEPGPLRRREAAAEARKSHSPVKRPRKAQRLRVAYEGSDSEKGEGAEPLKVPVWEPQDWQQQLVNIRAMRNKKDAPVDHLGTEHCYDSSAPPKVRRYQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRIANRLRWTKKATKSPEETRAALEEWLPRELWHEINGLLVGFGQQTCLPVHPRCHACLNQALCPAAQGL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MCSPQESGMT -----CCCHHHHHHH | 24043423 | ||
| 5 (in isoform 3) | Phosphorylation | - | 29116813 | ||
| 7 (in isoform 3) | Phosphorylation | - | 29116813 | ||
| 7 | Phosphorylation | -MCSPQESGMTALSA -CCCHHHHHHHHHHH | 24043423 | ||
| 10 | Phosphorylation | SPQESGMTALSARML CHHHHHHHHHHHHHH | 24043423 | ||
| 13 | Phosphorylation | ESGMTALSARMLTRS HHHHHHHHHHHHHHC | 22210691 | ||
| 18 | Phosphorylation | ALSARMLTRSRSLGP HHHHHHHHHCCCCCC | 22210691 | ||
| 20 | Phosphorylation | SARMLTRSRSLGPGA HHHHHHHCCCCCCCC | 22617229 | ||
| 21 | Methylation | ARMLTRSRSLGPGAG HHHHHHCCCCCCCCC | 115485689 | ||
| 22 | Phosphorylation | RMLTRSRSLGPGAGP HHHHHCCCCCCCCCC | 23401153 | ||
| 51 | Phosphorylation | AAAEARKSHSPVKRP HHHHHHHCCCCCCCC | 28152594 | ||
| 53 | Phosphorylation | AEARKSHSPVKRPRK HHHHHCCCCCCCCHH | 28152594 | ||
| 68 | Phosphorylation | AQRLRVAYEGSDSEK HHHEEEEEECCCCCC | 29255136 | ||
| 71 | Phosphorylation | LRVAYEGSDSEKGEG EEEEEECCCCCCCCC | 29255136 | ||
| 73 | Phosphorylation | VAYEGSDSEKGEGAE EEEECCCCCCCCCCC | 29255136 | ||
| 83 | Ubiquitination | GEGAEPLKVPVWEPQ CCCCCCCCCCCCCCC | 21906983 | ||
| 106 | Ubiquitination | IRAMRNKKDAPVDHL HHHHCCCCCCCCCCC | - | ||
| 121 | Phosphorylation | GTEHCYDSSAPPKVR CCCCCCCCCCCCHHH | 27251275 | ||
| 122 | Phosphorylation | TEHCYDSSAPPKVRR CCCCCCCCCCCHHHH | 27251275 | ||
| 130 | Phosphorylation | APPKVRRYQVLLSLM CCCHHHHHHHHHHHH | 20068231 | ||
| 135 | Phosphorylation | RRYQVLLSLMLSSQT HHHHHHHHHHHCCCC | 20068231 | ||
| 139 | Phosphorylation | VLLSLMLSSQTKDQV HHHHHHHCCCCCCHH | 20068231 | ||
| 140 | Phosphorylation | LLSLMLSSQTKDQVT HHHHHHCCCCCCHHH | 20068231 | ||
| 142 | Phosphorylation | SLMLSSQTKDQVTAG HHHHCCCCCCHHHHH | 20068231 | ||
| 147 | Phosphorylation | SQTKDQVTAGAMQRL CCCCCHHHHHHHHHH | 21406692 | ||
| 160 | Phosphorylation | RLRARGLTVDSILQT HHHHCCCCHHHHHCC | 22817900 | ||
| 163 | Phosphorylation | ARGLTVDSILQTDDA HCCCCHHHHHCCCCC | 22817900 | ||
| 167 | Phosphorylation | TVDSILQTDDATLGK CHHHHHCCCCCCHHH | 24144214 | ||
| 171 | Phosphorylation | ILQTDDATLGKLIYP HHCCCCCCHHHHHHC | 22817900 | ||
| 174 | Ubiquitination | TDDATLGKLIYPVGF CCCCCHHHHHHCCHH | - | ||
| 177 | Phosphorylation | ATLGKLIYPVGFWRS CCHHHHHHCCHHHHH | 24670416 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NTH_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NTH_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NTH_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MYH7_HUMAN | MYH7 | physical | 17353931 | |
| 8ODP_HUMAN | NUDT1 | physical | 17353931 | |
| MYH4_HUMAN | MYH4 | physical | 17353931 | |
| G3PT_HUMAN | GAPDHS | physical | 17353931 | |
| MRM3_HUMAN | RNMTL1 | physical | 17353931 | |
| ERCC5_HUMAN | ERCC5 | physical | 9927729 | |
| ZCCHV_HUMAN | ZC3HAV1 | physical | 22939629 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 616415 | Familial adenomatous polyposis 3 (FAP3) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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