MAP12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAP12_HUMAN
• UniProt AC: Q6UB28
• Protein Name: Methionine aminopeptidase 1D, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03174}
• Gene Name: METAP1D
• Organism: Homo sapiens (Human).
• Sequence Length: 335
• Subcellular Localization: Mitochondrion .
• Protein Description: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis..
• Protein Sequence: MAAPSGVHLLVRRGSHRIFSSPLNHIYLHKQSSSQQRRNFFFRRQRDISHSIVLPAAVSSAHPVPKHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPHFVGHGIGSYFHGHPEIWHHANDSDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRGAQILTKLPHEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	RGSHRIFSSPLNHIY CCCCEEECCCCCEEE		30206219
21	Phosphorylation	GSHRIFSSPLNHIYL CCCEEECCCCCEEEE		30206219
27	Phosphorylation	SSPLNHIYLHKQSSS CCCCCEEEECCCCCH		30206219
32	Phosphorylation	HIYLHKQSSSQQRRN EEEECCCCCHHHHHH		30206219
33	Phosphorylation	IYLHKQSSSQQRRNF EEECCCCCHHHHHHH		30206219
34	Phosphorylation	YLHKQSSSQQRRNFF EECCCCCHHHHHHHH		30206219
134	Phosphorylation	LVHREIISHNAYPSP HHHHHHHHCCCCCCC		29759185
138	Phosphorylation	EIISHNAYPSPLGYG HHHHCCCCCCCCCCC		29759185
140	Phosphorylation	ISHNAYPSPLGYGGF HHCCCCCCCCCCCCC		29759185
144	Phosphorylation	AYPSPLGYGGFPKSV CCCCCCCCCCCCHHH		28348404
321	Phosphorylation	FEHTVLITSRGAQIL EEEEEEEECHHCHHH		24719451
329	Phosphorylation	SRGAQILTKLPHEA- CHHCHHHHCCCCCC-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAP12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAP12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAP12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIR3_HUMAN	SIRT3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.