CHSTC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHSTC_HUMAN
• UniProt AC: Q9NRB3
• Protein Name: Carbohydrate sulfotransferase 12
• Gene Name: CHST12
• Organism: Homo sapiens (Human).
• Sequence Length: 414
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor..
• Protein Sequence: MTKARLFRLWLVLGSVFMILLIIVYWDSAGAAHFYLHTSFSRPHTGPPLPTPGPDRDRELTADSDVDEFLDKFLSAGVKQSDLPRKETEQPPAPGSMEESVRGYDWSPRDARRSPDQGRQQAERRSVLRGFCANSSLAFPTKERAFDDIPNSELSHLIVDDRHGAIYCYVPKVACTNWKRVMIVLSGSLLHRGAPYRDPLRIPREHVHNASAHLTFNKFWRRYGKLSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASAREAFRAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLQLLQVDRQLRFPPSYRNRTASSWEEDWFAKIPLAWRQQLYKLYEADFVLFGYPKPENLLRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Ubiquitination	DVDEFLDKFLSAGVK CHHHHHHHHHHHCCC	50.80	-
75	Phosphorylation	EFLDKFLSAGVKQSD HHHHHHHHHCCCHHH	26.55	-
79	Ubiquitination	KFLSAGVKQSDLPRK HHHHHCCCHHHCCCC	43.07	-
86	Ubiquitination	KQSDLPRKETEQPPA CHHHCCCCCCCCCCC	68.03	-
88	O-linked_Glycosylation	SDLPRKETEQPPAPG HHCCCCCCCCCCCCC	42.85	55828457
96	Phosphorylation	EQPPAPGSMEESVRG CCCCCCCCHHHHHCC	23.20	24505115
97	Sulfoxidation	QPPAPGSMEESVRGY CCCCCCCHHHHHCCC	9.08	21406390
107	Phosphorylation	SVRGYDWSPRDARRS HHCCCCCCHHHHCCC	13.73	24719451
134	N-linked_Glycosylation	VLRGFCANSSLAFPT HHHHHHCCCCCCCCC	33.06	UniProtKB CARBOHYD
142	Ubiquitination	SSLAFPTKERAFDDI CCCCCCCCCCCCCCC	45.50	-
172	Ubiquitination	AIYCYVPKVACTNWK EEEEEECHHHCCCCE	32.21	-
209	N-linked_Glycosylation	IPREHVHNASAHLTF CCHHHHCCCHHHHHH	34.21	UniProtKB CARBOHYD
240	Ubiquitination	VKLKKYTKFLFVRDP HHHHHCCEEEEECCH	36.66	-
253	Phosphorylation	DPFVRLISAFRSKFE CHHHHHHHHHHHHCC	26.41	24719451
258	Ubiquitination	LISAFRSKFELENEE HHHHHHHHCCCCCHH	38.30	-
280	N-linked_Glycosylation	PMLRLYANHTSLPAS HHHHHHCCCCCCCHH	25.97	UniProtKB CARBOHYD
282	Phosphorylation	LRLYANHTSLPASAR HHHHCCCCCCCHHHH	31.59	22210691
283	Phosphorylation	RLYANHTSLPASARE HHHCCCCCCCHHHHH	25.46	22210691
370	N-linked_Glycosylation	RFPPSYRNRTASSWE CCCHHHCCCCCCCCC	37.10	UniProtKB CARBOHYD
396	Phosphorylation	RQQLYKLYEADFVLF HHHHHHHHHCCEEEE	12.62	-
405	Phosphorylation	ADFVLFGYPKPENLL CCEEEECCCCHHHHC	10.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHSTC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHSTC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHSTC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UGGG1_HUMAN	UGGT1	physical	17353931
ATP23_HUMAN	XRCC6BP1	physical	28514442
RMND1_HUMAN	RMND1	physical	28514442
FBX2_HUMAN	FBXO2	physical	28514442
PON2_HUMAN	PON2	physical	28514442
SSRP1_HUMAN	SSRP1	physical	28514442
MD2L2_HUMAN	MAD2L2	physical	28514442
SE1L1_HUMAN	SEL1L	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.