CARF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CARF_MOUSE
• UniProt AC: Q8BI72
• Protein Name: CDKN2A-interacting protein
• Gene Name: Cdkn2aip
• Organism: Mus musculus (Mouse).
• Sequence Length: 563
• Subcellular Localization: Nucleus, nucleoplasm .
• Protein Description: Regulates DNA damage response and cell proliferation in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence..
• Protein Sequence: MAQEVSEYLSQNPRVAAWVETLRCEGETDKHWRHRREFLLRNAGDLVPATDETADAESGARTRQLQQLVSFSMAWANHVFLGCRYPQKVMDKILSMAEGIKVTDAPIHTTRDELVAKVKKRGISSSNEGVEEPSKKRAVEGKNNSSVERDHGKKSAKTDRSAAQQENSSPSRGSSTKSESGGTSARSSSSGSHQDSATSEGDRSVCSQSSSNSSQVTAGSGKALESEAPHKRGSASFVSSLLKSSMNSHMTQSTDNRQQSGSPKKGALEGSSGSASQSSSEIEVPLLGSSGSAEVELPLLSCKSSSETASSGLTSKSSSEANISSSVSKNSSSSGSSLLTPQSSSTNPSLLTSKSTAQVAASLLATKSGASLGSVSQLAAKSGSQSSTSQLPSKSTSQASESSVKFACRKLTNEDIKQKQPFFNRLYKTVAWKLVAVGGFSPTVNHGELLNAAIEALKATLDVFFVPLKELADLPQNKSSQESIVCELRCKSVYLGTGCGKSKENAKAVASREALKLFLKKKVVVKICKRKYRGSEIEDLVLLDEEARPVNLPPALKHPQELL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQEVSEYL ------CHHHHHHHH	17.78	-
92	Ubiquitination	YPQKVMDKILSMAEG CCHHHHHHHHHHHCC	27.70	22790023
95	Phosphorylation	KVMDKILSMAEGIKV HHHHHHHHHHCCCCC	21.30	30482847
124	Phosphorylation	KVKKRGISSSNEGVE HHHHCCCCCCCCCCC	30.45	26824392
125	Phosphorylation	VKKRGISSSNEGVEE HHHCCCCCCCCCCCC	34.95	30635358
126	Phosphorylation	KKRGISSSNEGVEEP HHCCCCCCCCCCCCC	31.91	28833060
134	Phosphorylation	NEGVEEPSKKRAVEG CCCCCCCHHHHCCCC	54.83	28833060
161	Phosphorylation	KSAKTDRSAAQQENS CCCHHHHHHHHHHHC	30.66	27149854
168	Phosphorylation	SAAQQENSSPSRGSS HHHHHHHCCCCCCCC	42.76	23684622
169	Phosphorylation	AAQQENSSPSRGSST HHHHHHCCCCCCCCC	38.18	25521595
171	Phosphorylation	QQENSSPSRGSSTKS HHHHCCCCCCCCCCC	51.74	27087446
174	Phosphorylation	NSSPSRGSSTKSESG HCCCCCCCCCCCCCC	33.45	23984901
175	Phosphorylation	SSPSRGSSTKSESGG CCCCCCCCCCCCCCC	42.55	22817900
176	Phosphorylation	SPSRGSSTKSESGGT CCCCCCCCCCCCCCC	40.04	23984901
187	Phosphorylation	SGGTSARSSSSGSHQ CCCCCCCCCCCCCCC	34.00	23684622
189	Phosphorylation	GTSARSSSSGSHQDS CCCCCCCCCCCCCCC	39.71	23684622
190	Phosphorylation	TSARSSSSGSHQDSA CCCCCCCCCCCCCCC	46.38	23684622
234	Phosphorylation	EAPHKRGSASFVSSL CCCCCCCCHHHHHHH	25.44	25521595
236	Phosphorylation	PHKRGSASFVSSLLK CCCCCCHHHHHHHHH	28.07	26239621
240	Phosphorylation	GSASFVSSLLKSSMN CCHHHHHHHHHHHHH	32.21	22817900
244	Phosphorylation	FVSSLLKSSMNSHMT HHHHHHHHHHHHHCC	34.49	27717184
245	Phosphorylation	VSSLLKSSMNSHMTQ HHHHHHHHHHHHCCC	22.01	21183079
248	Phosphorylation	LLKSSMNSHMTQSTD HHHHHHHHHCCCCCC	13.14	21183079
251	Phosphorylation	SSMNSHMTQSTDNRQ HHHHHHCCCCCCCCC	17.59	26643407
253	Phosphorylation	MNSHMTQSTDNRQQS HHHHCCCCCCCCCCC	28.67	26643407
254	Phosphorylation	NSHMTQSTDNRQQSG HHHCCCCCCCCCCCC	27.72	26643407
260	Phosphorylation	STDNRQQSGSPKKGA CCCCCCCCCCCCCCC	32.66	29895711
262	Phosphorylation	DNRQQSGSPKKGALE CCCCCCCCCCCCCCC	38.50	27087446
315	Phosphorylation	TASSGLTSKSSSEAN CHHCCCCCCCCCCCC	35.27	27841257
317	Phosphorylation	SSGLTSKSSSEANIS HCCCCCCCCCCCCCC	38.57	22668510
318	Phosphorylation	SGLTSKSSSEANISS CCCCCCCCCCCCCCC	35.61	25521595
319	Phosphorylation	GLTSKSSSEANISSS CCCCCCCCCCCCCCC	48.06	25266776
331	Phosphorylation	SSSVSKNSSSSGSSL CCCCCCCCCCCCCCC	35.02	25293948
332	Phosphorylation	SSVSKNSSSSGSSLL CCCCCCCCCCCCCCC	37.61	25293948
333	Phosphorylation	SVSKNSSSSGSSLLT CCCCCCCCCCCCCCC	38.24	25293948
334	Phosphorylation	VSKNSSSSGSSLLTP CCCCCCCCCCCCCCC	44.64	25293948
336	Phosphorylation	KNSSSSGSSLLTPQS CCCCCCCCCCCCCCC	21.54	25293948
337	Phosphorylation	NSSSSGSSLLTPQSS CCCCCCCCCCCCCCC	30.81	25293948
340	Phosphorylation	SSGSSLLTPQSSSTN CCCCCCCCCCCCCCC	25.28	-
371	Phosphorylation	LATKSGASLGSVSQL HHHCCCCCCCHHHHH	36.47	-
374	Phosphorylation	KSGASLGSVSQLAAK CCCCCCCHHHHHHHH	24.72	29514104
384	Phosphorylation	QLAAKSGSQSSTSQL HHHHHCCCCCCCCCC	33.70	30635358
405	Ubiquitination	QASESSVKFACRKLT CCCHHHHHHHHHHCC	29.23	22790023
428	Ubiquitination	PFFNRLYKTVAWKLV HHHHHHHHHHHHHHH	40.91	22790023
441	Phosphorylation	LVAVGGFSPTVNHGE HHHCCCCCCCCCHHH	23.96	26745281
443	Phosphorylation	AVGGFSPTVNHGELL HCCCCCCCCCHHHHH	32.51	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CARF_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CARF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CARF_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDN2A_MOUSE	Cdkn2a	physical	12154087
ARF_MOUSE	Cdkn2a	physical	12154087
CH60_HUMAN	HSPD1	physical	26496610
RIR1_HUMAN	RRM1	physical	26496610
SFSWA_HUMAN	SFSWAP	physical	26496610
TERF2_HUMAN	TERF2	physical	26496610
TFAP4_HUMAN	TFAP4	physical	26496610
SF01_HUMAN	SF1	physical	26496610
RBM10_HUMAN	RBM10	physical	26496610
AKA12_HUMAN	AKAP12	physical	26496610
XRN2_HUMAN	XRN2	physical	26496610
FND3A_HUMAN	FNDC3A	physical	26496610
PCF11_HUMAN	PCF11	physical	26496610
NUD18_HUMAN	NUDT18	physical	26496610
RM55_HUMAN	MRPL55	physical	26496610
CE024_HUMAN	C5orf24	physical	26496610
NANP_HUMAN	NANP	physical	26496610
ARID2_HUMAN	ARID2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.