TBRG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBRG1_MOUSE
• UniProt AC: Q3UB74
• Protein Name: Transforming growth factor beta regulator 1
• Gene Name: Tbrg1
• Organism: Mus musculus (Mouse).
• Sequence Length: 406
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability..
• Protein Sequence: MSVLSGLASEPRTPLSSKARMKRLPRKSQNEKYRLKYLRLRRAAKATVFENASICDEIARLEEKFLKAKEERRYLLKKLLQIHALTEGEPQAAAPSHSSSLPLPYGVTSSVGTMQGAGPSTGAEEPFAKKSKKEKKEKGKENSKLEVLKKTSKKKKMEGGARKLVRPIALDPSGQPVFPIGLGGLTVYSLGEIITNRPGFHDENAIYPVGYCSTRVYASMKCPDQKCLYTCQIKDGGVQPQFEIVPEDDPQNTIVGSSADACYEELLRAISATTGKLMPNPLSCGADFFGFSHPTIHNLIQSCPEAQNCVNYQWVKFDACKPRKGQLSQELPENDATMSLEAFQTQTFDDDHDDSILPGSLDLPELQHEAFVSSYQPEFLTHEPLVDTDLQHLKSPSQCSPIQSSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSVLSGLAS ------CCHHHCCCC	31.59	17242355
2	Phosphorylation	------MSVLSGLAS ------CCHHHCCCC	31.59	27717184
5	Phosphorylation	---MSVLSGLASEPR ---CCHHHCCCCCCC	29.61	19854140
9	Phosphorylation	SVLSGLASEPRTPLS CHHHCCCCCCCCCCC	53.85	25266776
13	Phosphorylation	GLASEPRTPLSSKAR CCCCCCCCCCCHHHH	39.02	26824392
16	Phosphorylation	SEPRTPLSSKARMKR CCCCCCCCHHHHHHC	30.88	26745281
17	Phosphorylation	EPRTPLSSKARMKRL CCCCCCCHHHHHHCC	37.71	29895711
395	Phosphorylation	TDLQHLKSPSQCSPI CCHHHCCCHHHCCCC	35.82	27087446
397	Phosphorylation	LQHLKSPSQCSPIQS HHHCCCHHHCCCCCC	51.41	29899451
400	Phosphorylation	LKSPSQCSPIQSSD- CCCHHHCCCCCCCC-	19.87	25521595
404	Phosphorylation	SQCSPIQSSD----- HHCCCCCCCC-----	36.87	28066266
405	Phosphorylation	QCSPIQSSD------ HCCCCCCCC------	30.85	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBRG1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBRG1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBRG1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDN2A_MOUSE	Cdkn2a	physical	17110379
ARF_MOUSE	Cdkn2a	physical	17110379
CDN2A_MOUSE	Cdkn2a	physical	16582619
ARF_MOUSE	Cdkn2a	physical	16582619
KAT5_HUMAN	KAT5	physical	24621507
MDM2_HUMAN	MDM2	physical	24621507

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.